Geospatial characterization of immune cell distributions and dynamics across the microenvironment in clear cell renal cell carcinoma

Nicholas H Chakiryan; Youngchul Kim; Anders Berglund; Andrew Chang; Gregory J Kimmel; Ali Hajiran; Jonathan Nguyen; Carlos Moran-Segura; Daryoush Saeed-Vafa; Esther N Katende; Neale Lopez-Blanco; Jad Chahoud; Phillip Rappold; Philippe E Spiess; Michelle Fournier; Daniel Jeong; Liang Wang; Jamie K Teer; Jasreman Dhillon; Fengshen Kuo; Abraham Ari Hakimi; Philipp M Altrock; James J Mulé; Brandon J Manley

doi:10.1136/jitc-2022-006195

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Clinical/translational cancer immunotherapy

Original research

Geospatial characterization of immune cell distributions and dynamics across the microenvironment in clear cell renal cell carcinoma

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Nicholas H Chakiryan Department of Genitourinary Oncology, H Lee Moffitt Cancer Center and Research Institute, Tampa, Florida, USATranslational Oncology, Oregon Health & Science University Knight Cancer Institute, Portland, Oregon, USA PubMed articles Google scholar articles
Youngchul Kim Biostatistics and Bioinformatics, H Lee Moffitt Cancer Center and Research Institute, Tampa, Florida, USA PubMed articles Google scholar articles
Anders Berglund Biostatistics and Bioinformatics, H Lee Moffitt Cancer Center and Research Institute, Tampa, Florida, USA PubMed articles Google scholar articles
Andrew Chang Department of Genitourinary Oncology, H Lee Moffitt Cancer Center and Research Institute, Tampa, Florida, USA PubMed articles Google scholar articles
Gregory J Kimmel Integrated Mathematical Oncology Department, H Lee Moffitt Cancer Center and Research Institute, Tampa, Florida, USA PubMed articles Google scholar articles
Ali Hajiran Department of Genitourinary Oncology, H Lee Moffitt Cancer Center and Research Institute, Tampa, Florida, USA PubMed articles Google scholar articles
Jonathan Nguyen Department of Pathology, H Lee Moffitt Cancer Center, Tampa, Florida, USA PubMed articles Google scholar articles
Carlos Moran-Segura Department of Pathology, H Lee Moffitt Cancer Center, Tampa, Florida, USA PubMed articles Google scholar articles
Daryoush Saeed-Vafa Department of Pathology, H Lee Moffitt Cancer Center, Tampa, Florida, USA PubMed articles Google scholar articles
Esther N Katende Department of Genitourinary Oncology, H Lee Moffitt Cancer Center and Research Institute, Tampa, Florida, USA PubMed articles Google scholar articles
Neale Lopez-Blanco Department of Pathology, H Lee Moffitt Cancer Center, Tampa, Florida, USA PubMed articles Google scholar articles
Jad Chahoud Department of Genitourinary Oncology, H Lee Moffitt Cancer Center and Research Institute, Tampa, Florida, USA PubMed articles Google scholar articles
Phillip Rappold Urology Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, New York, USA PubMed articles Google scholar articles
Philippe E Spiess Department of Genitourinary Oncology, H Lee Moffitt Cancer Center and Research Institute, Tampa, Florida, USA PubMed articles Google scholar articles
Michelle Fournier Tissue Core, H Lee Moffitt Cancer Center and Research Institute, Tampa, Florida, USA PubMed articles Google scholar articles
Daniel Jeong Department of Radiology, H Lee Moffitt Cancer Center, Tampa, Florida, USA PubMed articles Google scholar articles
Liang Wang Department of Tumor Biology, H Lee Moffitt Cancer Center and Research Institute, Tampa, Florida, USA PubMed articles Google scholar articles
Jamie K Teer Biostatistics and Bioinformatics, H Lee Moffitt Cancer Center and Research Institute, Tampa, Florida, USA PubMed articles Google scholar articles
Jasreman Dhillon Department of Pathology, H Lee Moffitt Cancer Center, Tampa, Florida, USA PubMed articles Google scholar articles
Fengshen Kuo Urology Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, New York, USA PubMed articles Google scholar articles
Abraham Ari Hakimi Urology Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, New York, USA PubMed articles Google scholar articles
Philipp M Altrock Department of Evolutionary Theory, Max Planck Institute for Evolutionary Biology, Ploen, Germany PubMed articles Google scholar articles
James J Mulé Department of Immunology, H Lee Moffitt Cancer Center and Research Institute, Tampa, Florida, USARadiation Oncology Program, H Lee Moffitt Cancer Center and Research Institute, Tampa, Florida, USACutaneous Oncology Program, H Lee Moffitt Cancer Center and Research Institute, Tampa, Florida, USA PubMed articles Google scholar articles
Brandon J Manley Department of Genitourinary Oncology, H Lee Moffitt Cancer Center and Research Institute, Tampa, Florida, USAIntegrated Mathematical Oncology Department, H Lee Moffitt Cancer Center and Research Institute, Tampa, Florida, USA PubMed articles Google scholar articles

Citation

Chakiryan NH, Kim Y, Berglund A, et al

Geospatial characterization of immune cell distributions and dynamics across the microenvironment in clear cell renal cell carcinoma

Journal for ImmunoTherapy of Cancer 2023;11:e006195. doi: 10.1136/jitc-2022-006195

Online issue publication

December 07, 2023

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© Author(s) (or their employer(s)) 2023. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ. http://creativecommons.org/licenses/by-nc/4.0/This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See http://creativecommons.org/licenses/by-nc/4.0/.

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