Cancer cell genotype associated tumor immune microenvironment exhibits differential response to therapeutic STING pathway activation in high-grade serous ovarian cancer

Noor Shakfa; Deyang Li; Gwenaelle Conseil; Elizabeth D Lightbody; Juliette Wilson-Sanchez; Ali Hamade; Stephen Chenard; Natasha A. Jawa; Brian J. Laight; Afrakoma Afriyie-Asante; Kathrin Tyryshkin; Martin Koebel; Madhuri Koti

doi:10.1136/jitc-2022-006170

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Oncolytic and local immunotherapy

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Cancer cell genotype associated tumor immune microenvironment exhibits differential response to therapeutic STING pathway activation in high-grade serous ovarian cancer

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Noor Shakfa Biomedical and Molecular Sciences, Queen's University, Kingston, Ontario, CanadaQueen's Cancer Research Institute, Queen's University, Kingston, Ontario, Canada PubMed articles Google scholar articles
Deyang Li Biomedical and Molecular Sciences, Queen's University, Kingston, Ontario, CanadaQueen's Cancer Research Institute, Queen's University, Kingston, Ontario, Canada PubMed articles Google scholar articles
Gwenaelle Conseil Biomedical and Molecular Sciences, Queen's University, Kingston, Ontario, CanadaQueen's Cancer Research Institute, Queen's University, Kingston, Ontario, Canada PubMed articles Google scholar articles
Elizabeth D Lightbody Dana-Farber Cancer Institute, Harvard University, Cambridge, Massachusetts, USA PubMed articles Google scholar articles
Juliette Wilson-Sanchez Biomedical and Molecular Sciences, Queen's University, Kingston, Ontario, CanadaQueen's Cancer Research Institute, Queen's University, Kingston, Ontario, Canada PubMed articles Google scholar articles
Ali Hamade Biomedical and Molecular Sciences, Queen's University, Kingston, Ontario, CanadaQueen's Cancer Research Institute, Queen's University, Kingston, Ontario, Canada PubMed articles Google scholar articles
Stephen Chenard Biomedical and Molecular Sciences, Queen's University, Kingston, Ontario, CanadaQueen's Cancer Research Institute, Queen's University, Kingston, Ontario, Canada PubMed articles Google scholar articles
Natasha A. Jawa Centre for Neuroscience Studies & School of Medicine, Queen's University, Kingston, Ontario, Canada PubMed articles Google scholar articles
Brian J. Laight Queen's Cancer Research Institute, Queen's University, Kingston, Ontario, CanadaPathology and Molecular Medicine, Queen's University Cancer Research Institute, Kingston, Ontario, Canada PubMed articles Google scholar articles
Afrakoma Afriyie-Asante Biochemistry, Microbiology and Immunology, University of Ottawa, Ottawa, Ontario, Canada PubMed articles Google scholar articles
Kathrin Tyryshkin Pathology and Molecular Medicine, Queen's University, Kingston, Ontario, Canada PubMed articles Google scholar articles
Martin Koebel Pathology and Laboratory Medicine, University of Calgary, Calgary, Alberta, Canada PubMed articles Google scholar articles
Madhuri Koti Biomedical and Molecular Sciences, Queen's University, Kingston, Ontario, CanadaQueen's Cancer Research Institute, Queen's University, Kingston, Ontario, Canada PubMed articles Google scholar articles

Citation

Shakfa N, Li D, Conseil G, et al

Cancer cell genotype associated tumor immune microenvironment exhibits differential response to therapeutic STING pathway activation in high-grade serous ovarian cancer

Journal for ImmunoTherapy of Cancer 2023;11:e006170. doi: 10.1136/jitc-2022-006170

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December 07, 2023

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© Author(s) (or their employer(s)) 2023. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ. http://creativecommons.org/licenses/by-nc/4.0/This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See http://creativecommons.org/licenses/by-nc/4.0/.

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