You are here

Article info

Article menu
Basic tumor immunology
Original research
Glucocorticoid activation by HSD11B1 limits T cell-driven interferon signaling and response to PD-1 blockade in melanoma

Authors

  • Luiza Martins Nascentes Melo Skin Cancer Unit of the Dermatology Department, Medical Faculty, West German Cancer Center, University Duisburg-Essen, Essen, GermanyGerman Cancer Consortium (DKTK), Partner Site Essen/Düsseldorf, Essen, Germany PubMed articlesGoogle scholar articles
  • Dayana Herrera-Rios Department of Dermatology and Allergy, University Hospital, Ludwig Maximilian University (LMU) Munich, Munich, GermanyGerman Cancer Consortium (DKTK), Partner Site Munich, Munich, Germany PubMed articlesGoogle scholar articles
  • Daniel Hinze Institute of Experimental Oncology (IEO), Medical Faculty, University Hospital Bonn, University of Bonn, Bonn, Germany PubMed articlesGoogle scholar articles
  • Stefanie Löffek Skin Cancer Unit of the Dermatology Department, Medical Faculty, West German Cancer Center, University Duisburg-Essen, Essen, GermanyGerman Cancer Consortium (DKTK), Partner Site Essen/Düsseldorf, Essen, Germany PubMed articlesGoogle scholar articles
  • Irem Oezel Department of Otorhinolaryngology, University Hospital Essen, University Duisburg-Essen, Essen, Germany PubMed articlesGoogle scholar articles
  • Roberta Turiello Institute of Experimental Oncology (IEO), Medical Faculty, University Hospital Bonn, University of Bonn, Bonn, Germany PubMed articlesGoogle scholar articles
  • Juliane Klein Department of Dermatology and Allergy, University Hospital, Ludwig Maximilian University (LMU) Munich, Munich, GermanyGerman Cancer Consortium (DKTK), Partner Site Munich, Munich, Germany PubMed articlesGoogle scholar articles
  • Sonia Leonardelli Institute of Experimental Oncology (IEO), Medical Faculty, University Hospital Bonn, University of Bonn, Bonn, Germany PubMed articlesGoogle scholar articles
  • Isa-Vanessa Westedt Skin Cancer Unit of the Dermatology Department, Medical Faculty, West German Cancer Center, University Duisburg-Essen, Essen, GermanyGerman Cancer Consortium (DKTK), Partner Site Essen/Düsseldorf, Essen, Germany PubMed articlesGoogle scholar articles
  • Yahya Al-Matary Skin Cancer Unit of the Dermatology Department, Medical Faculty, West German Cancer Center, University Duisburg-Essen, Essen, GermanyGerman Cancer Consortium (DKTK), Partner Site Essen/Düsseldorf, Essen, Germany PubMed articlesGoogle scholar articles
  • Sara Egea-Rodriguez Skin Cancer Unit of the Dermatology Department, Medical Faculty, West German Cancer Center, University Duisburg-Essen, Essen, GermanyDepartment of Dermatology and Allergy, University Hospital, Ludwig Maximilian University (LMU) Munich, Munich, GermanyGerman Cancer Consortium (DKTK), Partner Site Munich, Munich, Germany PubMed articlesGoogle scholar articles
  • Alexandra Brenzel Institute for Experimental Immunology and Imaging, University Hospital, University Duisburg-Essen, Essen, Germany PubMed articlesGoogle scholar articles
  • Maja Bau Skin Cancer Unit of the Dermatology Department, Medical Faculty, West German Cancer Center, University Duisburg-Essen, Essen, GermanyGerman Cancer Consortium (DKTK), Partner Site Essen/Düsseldorf, Essen, Germany PubMed articlesGoogle scholar articles
  • Antje Sucker Skin Cancer Unit of the Dermatology Department, Medical Faculty, West German Cancer Center, University Duisburg-Essen, Essen, GermanyGerman Cancer Consortium (DKTK), Partner Site Essen/Düsseldorf, Essen, Germany PubMed articlesGoogle scholar articles
  • Eva Hadaschik Skin Cancer Unit of the Dermatology Department, Medical Faculty, West German Cancer Center, University Duisburg-Essen, Essen, Germany PubMed articlesGoogle scholar articles
  • Florian Wirsdörfer Institute of Cell Biology (Cancer Research), University Hospital Essen, University of Duisburg-Essen, Essen, Germany PubMed articlesGoogle scholar articles
  • Helmut Hanenberg Department of Pediatrics III, University Children's Hospital Essen, University Duisburg-Essen, Essen, Germany PubMed articlesGoogle scholar articles
  • Niklas Uhlenbrock Drug Discovery Hub Dortmund (DDHD) am Zentrum für integrierte Wirkstoffforschung (ZIW), Dortmund, BelgiumFaculty of Chemistry and Chemical Biology, TU Dortmund University, Dortmund, Germany PubMed articlesGoogle scholar articles
  • Daniel Rauh Drug Discovery Hub Dortmund (DDHD) am Zentrum für integrierte Wirkstoffforschung (ZIW), Dortmund, BelgiumFaculty of Chemistry and Chemical Biology, TU Dortmund University, Dortmund, Germany PubMed articlesGoogle scholar articles
  • Joanna Poźniak Center for Cancer Biology, VIB-KU Leuven, Leuven, BelgiumDepartment of Oncology, KU Leuven, Leuven, Belgium PubMed articlesGoogle scholar articles
  • Florian Rambow Skin Cancer Unit of the Dermatology Department, Medical Faculty, West German Cancer Center, University Duisburg-Essen, Essen, GermanyGerman Cancer Consortium (DKTK), Partner Site Essen/Düsseldorf, Essen, GermanyCenter for Cancer Biology, VIB-KU Leuven, Leuven, BelgiumDepartment of Oncology, KU Leuven, Leuven, Belgium PubMed articlesGoogle scholar articles
  • Jean-Christophe Marine Center for Cancer Biology, VIB-KU Leuven, Leuven, BelgiumDepartment of Oncology, KU Leuven, Leuven, Belgium PubMed articlesGoogle scholar articles
  • Maike Effern Institute of Experimental Oncology (IEO), Medical Faculty, University Hospital Bonn, University of Bonn, Bonn, Germany PubMed articlesGoogle scholar articles
  • Nicole Glodde Institute of Experimental Oncology (IEO), Medical Faculty, University Hospital Bonn, University of Bonn, Bonn, Germany PubMed articlesGoogle scholar articles
  • Dirk Schadendorf Skin Cancer Unit of the Dermatology Department, Medical Faculty, West German Cancer Center, University Duisburg-Essen, Essen, GermanyGerman Cancer Consortium (DKTK), Partner Site Essen/Düsseldorf, Essen, Germany PubMed articlesGoogle scholar articles
  • Jadwiga Jablonska German Cancer Consortium (DKTK), Partner Site Essen/Düsseldorf, Essen, GermanyDepartment of Otorhinolaryngology, University Hospital Essen, University Duisburg-Essen, Essen, Germany PubMed articlesGoogle scholar articles
  • Michael Hölzel Institute of Experimental Oncology (IEO), Medical Faculty, University Hospital Bonn, University of Bonn, Bonn, Germany PubMed articlesGoogle scholar articles
  • Iris Helfrich Skin Cancer Unit of the Dermatology Department, Medical Faculty, West German Cancer Center, University Duisburg-Essen, Essen, GermanyDepartment of Dermatology and Allergy, University Hospital, Ludwig Maximilian University (LMU) Munich, Munich, GermanyGerman Cancer Consortium (DKTK), Partner Site Munich, Munich, Germany PubMed articlesGoogle scholar articles

Citation

Martins Nascentes Melo L, Herrera-Rios D, Hinze D, et al
Glucocorticoid activation by HSD11B1 limits T cell-driven interferon signaling and response to PD-1 blockade in melanoma
Journal for ImmunoTherapy of Cancer 2023;11:e004150. doi: 10.1136/jitc-2021-004150
Online issue publication 
December 07, 2023

Request permissions

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.

Copyright information

© Author(s) (or their employer(s)) 2023. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ. http://creativecommons.org/licenses/by-nc/4.0/This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See http://creativecommons.org/licenses/by-nc/4.0/.