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  • Inactivation of interleukin-30 in colon cancer stem cells via CRISPR/Cas9 genome editing inhibits their oncogenicity and improves host survival

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Basic tumor immunology
Original research
Inactivation of interleukin-30 in colon cancer stem cells via CRISPR/Cas9 genome editing inhibits their oncogenicity and improves host survival

Authors

  • Luigi D'Antonio Dipartimento di Medicina e Scienze dell'Invecchiamento, Università degli Studi "G. d'Annunzio" di Chieti-Pescara, Chieti, ItalyCenter for Advanced Studies and Technology (CAST), Università degli Studi "G. d'Annunzio" di Chieti-Pescara, Chieti, Italy PubMed articlesGoogle scholar articles
  • Cristiano Fieni Dipartimento di Medicina e Scienze dell'Invecchiamento, Università degli Studi "G. d'Annunzio" di Chieti-Pescara, Chieti, ItalyCenter for Advanced Studies and Technology (CAST), Università degli Studi "G. d'Annunzio" di Chieti-Pescara, Chieti, Italy PubMed articlesGoogle scholar articles
  • Stefania Livia Ciummo Dipartimento di Medicina e Scienze dell'Invecchiamento, Università degli Studi "G. d'Annunzio" di Chieti-Pescara, Chieti, ItalyCenter for Advanced Studies and Technology (CAST), Università degli Studi "G. d'Annunzio" di Chieti-Pescara, Chieti, Italy PubMed articlesGoogle scholar articles
  • Simone Vespa Dipartimento di Medicina e Scienze dell'Invecchiamento, Università degli Studi "G. d'Annunzio" di Chieti-Pescara, Chieti, Italy PubMed articlesGoogle scholar articles
  • Lavinia Lotti Department of Experimental Medicine, University of Rome La Sapienza, Rome, Italy PubMed articlesGoogle scholar articles
  • Carlo Sorrentino Dipartimento di Medicina e Scienze dell'Invecchiamento, Università degli Studi "G. d'Annunzio" di Chieti-Pescara, Chieti, ItalyCenter for Advanced Studies and Technology (CAST), Università degli Studi "G. d'Annunzio" di Chieti-Pescara, Chieti, Italy PubMed articlesGoogle scholar articles
  • Emma Di Carlo Dipartimento di Medicina e Scienze dell'Invecchiamento, Università degli Studi "G. d'Annunzio" di Chieti-Pescara, Chieti, ItalyCenter for Advanced Studies and Technology (CAST), Università degli Studi "G. d'Annunzio" di Chieti-Pescara, Chieti, Italy PubMed articlesGoogle scholar articles

Citation

D'Antonio L, Fieni C, Ciummo SL, et al
Inactivation of interleukin-30 in colon cancer stem cells via CRISPR/Cas9 genome editing inhibits their oncogenicity and improves host survival
Journal for ImmunoTherapy of Cancer 2023;11:e006056. doi: 10.1136/jitc-2022-006056
Online issue publication 
October 18, 2023

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© Author(s) (or their employer(s)) 2023. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ. http://creativecommons.org/licenses/by-nc/4.0/This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See http://creativecommons.org/licenses/by-nc/4.0/.