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  • T cell-mediated targeted delivery of tadalafil regulates immunosuppression and polyamine metabolism to overcome immune checkpoint blockade resistance in hepatocellular carcinoma

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Clinical/translational cancer immunotherapy
Original research
T cell-mediated targeted delivery of tadalafil regulates immunosuppression and polyamine metabolism to overcome immune checkpoint blockade resistance in hepatocellular carcinoma

Authors

  • Xiaobin Wang Laboratory of Interventional Radiology, Department of Minimally Invasive Interventional Radiology and Interventional Cancer Center, the Second Affiliated Hospital, Guangzhou Medical University, Guangzhou, China PubMed articlesGoogle scholar articles
  • Qiaoyun Zhang College of Chemistry and Materials Science, Jinan University, Guangzhou, China PubMed articlesGoogle scholar articles
  • Jingwen Zhou Laboratory of Interventional Radiology, Department of Minimally Invasive Interventional Radiology and Interventional Cancer Center, the Second Affiliated Hospital, Guangzhou Medical University, Guangzhou, China PubMed articlesGoogle scholar articles
  • Zecong Xiao Laboratory of Interventional Radiology, Department of Minimally Invasive Interventional Radiology and Interventional Cancer Center, the Second Affiliated Hospital, Guangzhou Medical University, Guangzhou, China PubMed articlesGoogle scholar articles
  • Jianxin Liu Laboratory of Interventional Radiology, Department of Minimally Invasive Interventional Radiology and Interventional Cancer Center, the Second Affiliated Hospital, Guangzhou Medical University, Guangzhou, China PubMed articlesGoogle scholar articles
  • Shaohui Deng PCFM Lab of Ministry of Education School of Materials Science and Engineering, Sun Yat-Sen University, Guangzhou, China PubMed articlesGoogle scholar articles
  • Xiaoyang Hong Laboratory of Interventional Radiology, Department of Minimally Invasive Interventional Radiology and Interventional Cancer Center, the Second Affiliated Hospital, Guangzhou Medical University, Guangzhou, China PubMed articlesGoogle scholar articles
  • Wensou Huang Laboratory of Interventional Radiology, Department of Minimally Invasive Interventional Radiology and Interventional Cancer Center, the Second Affiliated Hospital, Guangzhou Medical University, Guangzhou, China PubMed articlesGoogle scholar articles
  • Mingyue Cai Laboratory of Interventional Radiology, Department of Minimally Invasive Interventional Radiology and Interventional Cancer Center, the Second Affiliated Hospital, Guangzhou Medical University, Guangzhou, China PubMed articlesGoogle scholar articles
  • Yongjian Guo Laboratory of Interventional Radiology, Department of Minimally Invasive Interventional Radiology and Interventional Cancer Center, the Second Affiliated Hospital, Guangzhou Medical University, Guangzhou, China PubMed articlesGoogle scholar articles
  • Jingjun Huang Laboratory of Interventional Radiology, Department of Minimally Invasive Interventional Radiology and Interventional Cancer Center, the Second Affiliated Hospital, Guangzhou Medical University, Guangzhou, China PubMed articlesGoogle scholar articles
  • Yong Wang College of Chemistry and Materials Science, Jinan University, Guangzhou, China PubMed articlesGoogle scholar articles
  • Liteng Lin Laboratory of Interventional Radiology, Department of Minimally Invasive Interventional Radiology and Interventional Cancer Center, the Second Affiliated Hospital, Guangzhou Medical University, Guangzhou, China PubMed articlesGoogle scholar articles
  • Kangshun Zhu Laboratory of Interventional Radiology, Department of Minimally Invasive Interventional Radiology and Interventional Cancer Center, the Second Affiliated Hospital, Guangzhou Medical University, Guangzhou, China PubMed articlesGoogle scholar articles

Citation

Wang X, Zhang Q, Zhou J, et al
T cell-mediated targeted delivery of tadalafil regulates immunosuppression and polyamine metabolism to overcome immune checkpoint blockade resistance in hepatocellular carcinoma
Journal for ImmunoTherapy of Cancer 2023;11:e006493. doi: 10.1136/jitc-2022-006493
Online issue publication 
October 18, 2023

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© Author(s) (or their employer(s)) 2023. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ. http://creativecommons.org/licenses/by-nc/4.0/This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See http://creativecommons.org/licenses/by-nc/4.0/.