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  • Synergistic therapeutic combination with a CAF inhibitor enhances CAR-NK-mediated cytotoxicity via reduction of CAF-released IL-6

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Immune cell therapies and immune cell engineering
Original research
Synergistic therapeutic combination with a CAF inhibitor enhances CAR-NK-mediated cytotoxicity via reduction of CAF-released IL-6

Authors

  • Young Eun Lee Medicinal Materials Research Center, Biomedical Research Division, Korea Institute of Science and Technology, Seoul, Korea (the Republic of)Department of Life Sciences, College of Life Sciences and Biotechnology, Korea University, Seoul, Korea (the Republic of) PubMed articlesGoogle scholar articles
  • Ga-Yeon Go Medicinal Materials Research Center, Biomedical Research Division, Korea Institute of Science and Technology, Seoul, Korea (the Republic of) PubMed articlesGoogle scholar articles
  • Eun-Young Koh Department of Convergence Medicine, Asan Institute for Life Sciences, University of Ulsan College of Medicine and Asan Medical Center, Seoul, Korea (the Republic of) PubMed articlesGoogle scholar articles
  • Han-Na Yoon Medicinal Materials Research Center, Biomedical Research Division, Korea Institute of Science and Technology, Seoul, Korea (the Republic of) PubMed articlesGoogle scholar articles
  • Minkoo Seo Corporate Research & Development Center, UCI therapeutics, Seoul, Korea (the Republic of) PubMed articlesGoogle scholar articles
  • Seung-Mo Hong Department of Pathology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea (the Republic of) PubMed articlesGoogle scholar articles
  • Ji Hye Jeong Department of Convergence Medicine, Asan Institute for Life Sciences, University of Ulsan College of Medicine and Asan Medical Center, Seoul, Korea (the Republic of) PubMed articlesGoogle scholar articles
  • Jin-Chul Kim Natural Product Research Center, Institute of Natural Products, Korea Institute of Science and Technology, Gangneung, Korea (the Republic of) PubMed articlesGoogle scholar articles
  • Duck Cho Department of Health Sciences and Technology, Samsung Advanced Institute for Health Sciences and Technology (SAIHST), Sungkyunkwan University, Seoul, Korea (the Republic of)Department of Laboratory Medicine and Genetics, Samsung Medical Center, Sungkyunkwan University, Seoul, Korea (the Republic of) PubMed articlesGoogle scholar articles
  • Tae Sung Kim Department of Life Sciences, College of Life Sciences and Biotechnology, Korea University, Seoul, Korea (the Republic of) PubMed articlesGoogle scholar articles
  • Song Cheol Kim Division of Hepato-Biliary and Pancreatic Surgery, Department of Surgery, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Korea (the Republic of) PubMed articlesGoogle scholar articles
  • Eunsung Jun Department of Convergence Medicine, Asan Institute for Life Sciences, University of Ulsan College of Medicine and Asan Medical Center, Seoul, Korea (the Republic of)Division of Hepato-Biliary and Pancreatic Surgery, Department of Surgery, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Korea (the Republic of) PubMed articlesGoogle scholar articles
  • Mihue Jang Medicinal Materials Research Center, Biomedical Research Division, Korea Institute of Science and Technology, Seoul, Korea (the Republic of)KHU-KIST Department of Converging Science and Technology, Kyung Hee University, Seoul, Korea (the Republic of) PubMed articlesGoogle scholar articles

Citation

Lee YE, Go G, Koh E, et al
Synergistic therapeutic combination with a CAF inhibitor enhances CAR-NK-mediated cytotoxicity via reduction of CAF-released IL-6
Journal for ImmunoTherapy of Cancer 2023;11:e006130. doi: 10.1136/jitc-2022-006130
Online issue publication 
October 18, 2023

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© Author(s) (or their employer(s)) 2023. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ. http://creativecommons.org/licenses/by-nc/4.0/This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See http://creativecommons.org/licenses/by-nc/4.0/.