BRCA1 deficiency in mature CD8+ T lymphocytes impairs antitumor immunity

Bogang Wu; Leilei Qi; Huai-Chin Chiang; Haihui Pan; Xiaowen Zhang; Alexandra Greenbaum; Elizabeth Stark; Li-Ju Wang; Yidong Chen; Bassem R. Haddad; Dionyssia Clagett; Claudine Isaacs; Richard Elledge; Anelia Horvath; Yanfen Hu; Rong Li

doi:10.1136/jitc-2022-005852

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Basic tumor immunology

BRCA1 deficiency in mature CD8⁺ T lymphocytes impairs antitumor immunity

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Bogang Wu Department of Biochemistry & Molecular Medicine, School of Medicine & Health Sciences, The George Washington University, Washington, District of Columbia, USA PubMed articles Google scholar articles
Leilei Qi Department of Anatomy & Cell Biology, School of Medicine & Health Sciences, The George Washington University, Washington, District of Columbia, USA PubMed articles Google scholar articles
Huai-Chin Chiang Department of Biochemistry & Molecular Medicine, School of Medicine & Health Sciences, The George Washington University, Washington, District of Columbia, USA PubMed articles Google scholar articles
Haihui Pan Department of Biochemistry & Molecular Medicine, School of Medicine & Health Sciences, The George Washington University, Washington, District of Columbia, USA PubMed articles Google scholar articles
Xiaowen Zhang Department of Biochemistry & Molecular Medicine, School of Medicine & Health Sciences, The George Washington University, Washington, District of Columbia, USA PubMed articles Google scholar articles
Alexandra Greenbaum Ruth Paul Cancer Genetics and Prevention Program, Medical Faculty Associates, The George Washington University, Washington, District of Columbia, USA PubMed articles Google scholar articles
Elizabeth Stark Ruth Paul Cancer Genetics and Prevention Program, Medical Faculty Associates, The George Washington University, Washington, District of Columbia, USA PubMed articles Google scholar articles
Li-Ju Wang Department of Biostatistics, The University of Texas Health Science Center at San Antonio, San Antonio, Texas, USA PubMed articles Google scholar articles
Yidong Chen Department of Biostatistics, The University of Texas Health Science Center at San Antonio, San Antonio, Texas, USA PubMed articles Google scholar articles
Bassem R. Haddad Lombardi Comprehensive Cancer Center, Georgetown University, Washington, District of Columbia, USA PubMed articles Google scholar articles
Dionyssia Clagett Lombardi Comprehensive Cancer Center, Georgetown University, Washington, District of Columbia, USA PubMed articles Google scholar articles
Claudine Isaacs Lombardi Comprehensive Cancer Center, Georgetown University, Washington, District of Columbia, USA PubMed articles Google scholar articles
Richard Elledge San Antonio State Hospital, San Antonio, Texas, USA PubMed articles Google scholar articles
Anelia Horvath Department of Biochemistry & Molecular Medicine, School of Medicine & Health Sciences, The George Washington University, Washington, District of Columbia, USA PubMed articles Google scholar articles
Yanfen Hu Department of Anatomy & Cell Biology, School of Medicine & Health Sciences, The George Washington University, Washington, District of Columbia, USA PubMed articles Google scholar articles
Rong Li Department of Biochemistry & Molecular Medicine, School of Medicine & Health Sciences, The George Washington University, Washington, District of Columbia, USA PubMed articles Google scholar articles

Citation

Wu B, Qi L, Chiang H, et al

BRCA1 deficiency in mature CD8⁺ T lymphocytes impairs antitumor immunity

Journal for ImmunoTherapy of Cancer 2023;11:e005852. doi: 10.1136/jitc-2022-005852

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October 18, 2023

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© Author(s) (or their employer(s)) 2023. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ. http://creativecommons.org/licenses/by-nc/4.0/This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See http://creativecommons.org/licenses/by-nc/4.0/.

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