Neoantigen-specific CD4+ tumor-infiltrating lymphocytes are potent effectors identified within adoptive cell therapy products for metastatic melanoma patients

MacLean S. Hall; Jamie K. Teer; Xiaoqing Yu; Holly Branthoover; Sebastian Snedal; Madeline Rodriguez-Valentin; Luz Nagle; Ellen Scott; Ben Schachner; Patrick Innamarato; Amy M. Hall; Jamie Blauvelt; Carolyn J. Rich; Allison D. Richards; Jake Ceccarelli; TJ Langer; Sean J. Yoder; Matthew S. Beatty; Cheryl A. Cox; Jane L. Messina; Daniel Abate-Daga; James J. Mule; John E. Mullinax; Amod A. Sarnaik; Shari Pilon-Thomas

doi:10.1136/jitc-2023-007288

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Immune cell therapies and immune cell engineering

Original research

Neoantigen-specific CD4⁺ tumor-infiltrating lymphocytes are potent effectors identified within adoptive cell therapy products for metastatic melanoma patients

Authors

MacLean S. Hall Department of Immunology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida, USACancer Biology PhD Program, University of South Florida, Tampa, Florida, USA PubMed articles Google scholar articles
Jamie K. Teer Department of Biostatistics and Bioinformatics, H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida, USA PubMed articles Google scholar articles
Xiaoqing Yu Department of Biostatistics and Bioinformatics, H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida, USA PubMed articles Google scholar articles
Holly Branthoover Department of Immunology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida, USA PubMed articles Google scholar articles
Sebastian Snedal Department of Immunology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida, USA PubMed articles Google scholar articles
Madeline Rodriguez-Valentin Department of Immunology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida, USA PubMed articles Google scholar articles
Luz Nagle Department of Immunology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida, USA PubMed articles Google scholar articles
Ellen Scott Department of Immunology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida, USA PubMed articles Google scholar articles
Ben Schachner Department of Immunology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida, USA PubMed articles Google scholar articles
Patrick Innamarato Department of Immunology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida, USA PubMed articles Google scholar articles
Amy M. Hall Department of Immunology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida, USA PubMed articles Google scholar articles
Jamie Blauvelt Department of Immunology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida, USA PubMed articles Google scholar articles
Carolyn J. Rich Department of Cutaneous Oncology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida, USA PubMed articles Google scholar articles
Allison D. Richards Department of Cutaneous Oncology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida, USA PubMed articles Google scholar articles
Jake Ceccarelli Turnstone Biologics, Inc, San Diego, California, USA PubMed articles Google scholar articles
TJ Langer Turnstone Biologics, Inc, San Diego, California, USA PubMed articles Google scholar articles
Sean J. Yoder Molecular Genomics Core, H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida, USA PubMed articles Google scholar articles
Matthew S. Beatty Department of Immunology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida, USA PubMed articles Google scholar articles
Cheryl A. Cox Cell Therapies Core Facility, H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida, USA PubMed articles Google scholar articles
Jane L. Messina Department of Anatomic Pathology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida, USA PubMed articles Google scholar articles
Daniel Abate-Daga Department of Immunology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida, USA PubMed articles Google scholar articles
James J. Mule Department of Immunology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida, USA PubMed articles Google scholar articles
John E. Mullinax Department of Immunology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida, USADepartment of Sarcoma, H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida, USA PubMed articles Google scholar articles
Amod A. Sarnaik Department of Immunology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida, USADepartment of Cutaneous Oncology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida, USA PubMed articles Google scholar articles
Shari Pilon-Thomas Department of Immunology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida, USA PubMed articles Google scholar articles

Citation

Hall MS, Teer JK, Yu X, et al

Neoantigen-specific CD4⁺ tumor-infiltrating lymphocytes are potent effectors identified within adoptive cell therapy products for metastatic melanoma patients

Journal for ImmunoTherapy of Cancer 2023;11:e007288. doi: 10.1136/jitc-2023-007288

Online issue publication

October 06, 2023

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© Author(s) (or their employer(s)) 2023. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ. http://creativecommons.org/licenses/by-nc/4.0/This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See http://creativecommons.org/licenses/by-nc/4.0/.

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