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  • Single-cell transcriptomics identifies pathogenic T-helper 17.1 cells and pro-inflammatory monocytes in immune checkpoint inhibitor-related pneumonitis

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Clinical/translational cancer immunotherapy
Original research
Single-cell transcriptomics identifies pathogenic T-helper 17.1 cells and pro-inflammatory monocytes in immune checkpoint inhibitor-related pneumonitis

Authors

  • Amelie Franken VIB - CCB Department of Human Genetics, KU Leuven, Leuven, Flemish Brabant, Belgium PubMed articlesGoogle scholar articles
  • Pierre Van Mol VIB - CCB Department of Human Genetics, KU Leuven, Leuven, Flemish Brabant, BelgiumPneumology - Respiratory Oncology, Katholieke Universiteit Leuven Universitaire Ziekenhuizen Leuven, Leuven, Flemish Brabant, Belgium PubMed articlesGoogle scholar articles
  • Sam Vanmassenhove VIB - CCB Department of Human Genetics, KU Leuven, Leuven, Flemish Brabant, Belgium PubMed articlesGoogle scholar articles
  • Elena Donders VIB - CCB Department of Human Genetics, KU Leuven, Leuven, Flemish Brabant, BelgiumPneumology - Respiratory Oncology, Katholieke Universiteit Leuven Universitaire Ziekenhuizen Leuven, Leuven, Flemish Brabant, Belgium PubMed articlesGoogle scholar articles
  • Rogier Schepers VIB - CCB Department of Human Genetics, KU Leuven, Leuven, Flemish Brabant, Belgium PubMed articlesGoogle scholar articles
  • Thomas Van Brussel VIB - CCB Department of Human Genetics, KU Leuven, Leuven, Flemish Brabant, Belgium PubMed articlesGoogle scholar articles
  • Christophe Dooms Pneumology - Respiratory Oncology, Katholieke Universiteit Leuven Universitaire Ziekenhuizen Leuven, Leuven, Flemish Brabant, BelgiumDepartment of Chronic Diseases and Metabolism, KU Leuven, Leuven, Flemish Brabant, Belgium PubMed articlesGoogle scholar articles
  • Jonas Yserbyt Pneumology, Katholieke Universiteit Leuven Universitaire Ziekenhuizen Leuven, Leuven, Flemish Brabant, Belgium PubMed articlesGoogle scholar articles
  • Nico De Crem Pneumology, Katholieke Universiteit Leuven Universitaire Ziekenhuizen Leuven, Leuven, Flemish Brabant, Belgium PubMed articlesGoogle scholar articles
  • Dries Testelmans Department of Chronic Diseases and Metabolism, KU Leuven, Leuven, Flemish Brabant, BelgiumPneumology, Katholieke Universiteit Leuven Universitaire Ziekenhuizen Leuven, Leuven, Flemish Brabant, Belgium PubMed articlesGoogle scholar articles
  • Walter De Wever Department of Imaging & Pathology, KU Leuven, Leuven, Flemish Brabant, Belgium PubMed articlesGoogle scholar articles
  • Kristiaan Nackaerts Pneumology - Respiratory Oncology, Katholieke Universiteit Leuven Universitaire Ziekenhuizen Leuven, Leuven, Flemish Brabant, BelgiumDepartment of Chronic Diseases and Metabolism, KU Leuven, Leuven, Flemish Brabant, Belgium PubMed articlesGoogle scholar articles
  • Johan Vansteenkiste Pneumology - Respiratory Oncology, Katholieke Universiteit Leuven Universitaire Ziekenhuizen Leuven, Leuven, Flemish Brabant, BelgiumDepartment of Chronic Diseases and Metabolism, KU Leuven, Leuven, Flemish Brabant, Belgium PubMed articlesGoogle scholar articles
  • Robin Vos Department of Chronic Diseases and Metabolism, KU Leuven, Leuven, Flemish Brabant, BelgiumPneumology, Katholieke Universiteit Leuven Universitaire Ziekenhuizen Leuven, Leuven, Flemish Brabant, Belgium PubMed articlesGoogle scholar articles
  • Stéphanie Humblet-Baron Department of Microbiology, Immunology and Transplantation, KU Leuven, Leuven, Flemish Brabant, Belgium PubMed articlesGoogle scholar articles
  • Diether Lambrechts VIB - CCB Department of Human Genetics, KU Leuven, Leuven, Flemish Brabant, Belgium PubMed articlesGoogle scholar articles
  • Els Wauters Pneumology - Respiratory Oncology, Katholieke Universiteit Leuven Universitaire Ziekenhuizen Leuven, Leuven, Flemish Brabant, BelgiumDepartment of Chronic Diseases and Metabolism, KU Leuven, Leuven, Flemish Brabant, Belgium PubMed articlesGoogle scholar articles

Citation

Franken A, Van Mol P, Vanmassenhove S, et al
Single-cell transcriptomics identifies pathogenic T-helper 17.1 cells and pro-inflammatory monocytes in immune checkpoint inhibitor-related pneumonitis
Journal for ImmunoTherapy of Cancer 2022;10:e005323. doi: 10.1136/jitc-2022-005323
Online issue publication 
September 28, 2022

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© Author(s) (or their employer(s)) 2022. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ. http://creativecommons.org/licenses/by-nc/4.0/This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See http://creativecommons.org/licenses/by-nc/4.0/.