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Immune cell therapies and immune cell engineering
Original research
Development of GPC2-directed chimeric antigen receptors using mRNA for pediatric brain tumors

Authors

  • Jessica B Foster Division of Oncology, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA Department of Pediatrics, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, USA Center for Data-Driven Discovery in Biomedicine, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA PubMed articlesGoogle scholar articles
  • Crystal Griffin Center for Data-Driven Discovery in Biomedicine, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA PubMed articlesGoogle scholar articles
  • Jo Lynne Rokita Center for Data-Driven Discovery in Biomedicine, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA Department of Bioinformatics and Health Informatics, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA Division of Neurosurgery, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA PubMed articlesGoogle scholar articles
  • Allison Stern Center for Data-Driven Discovery in Biomedicine, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA PubMed articlesGoogle scholar articles
  • Cameron Brimley Division of Neurosurgery, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA PubMed articlesGoogle scholar articles
  • Komal Rathi Center for Data-Driven Discovery in Biomedicine, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA Department of Bioinformatics and Health Informatics, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA PubMed articlesGoogle scholar articles
  • Maria V Lane Division of Oncology, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA PubMed articlesGoogle scholar articles
  • Samantha N Buongervino Division of Oncology, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA PubMed articlesGoogle scholar articles
  • Tiffany Smith Center for Data-Driven Discovery in Biomedicine, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA PubMed articlesGoogle scholar articles
  • Peter J Madsen Center for Data-Driven Discovery in Biomedicine, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA Division of Neurosurgery, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA PubMed articlesGoogle scholar articles
  • Daniel Martinez Department of Pathology & Laboratory Medicine, The Children's Hospital of Philadelphia, Philadelphia, PA, USA PubMed articlesGoogle scholar articles
  • Alberto Delaidelli Department of Pathology & Laboratory Medicine, The University of British Columbia, Vancouver, British Columbia, Canada PubMed articlesGoogle scholar articles
  • Poul H Sorensen Department of Pathology & Laboratory Medicine, The University of British Columbia, Vancouver, British Columbia, Canada PubMed articlesGoogle scholar articles
  • Robert J Wechsler-Reya Tumor Initiation and Maintenance Program, NCI-Designated Cancer Center, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, California, USA PubMed articlesGoogle scholar articles
  • Katalin Karikó BioNTech SE, Mainz, Rheinland-Pfalz, Germany PubMed articlesGoogle scholar articles
  • Phillip B Storm Center for Data-Driven Discovery in Biomedicine, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA Division of Neurosurgery, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA Department of Neurosurgery, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, USA PubMed articlesGoogle scholar articles
  • David M Barrett Tmunity Therapeutics, Philadelphia, Pennsylvania, USA PubMed articlesGoogle scholar articles
  • Adam C Resnick Center for Data-Driven Discovery in Biomedicine, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA Division of Neurosurgery, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA PubMed articlesGoogle scholar articles
  • John M Maris Division of Oncology, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA Department of Pediatrics, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, USA PubMed articlesGoogle scholar articles
  • Kristopher R Bosse Division of Oncology, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA Department of Pediatrics, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, USA PubMed articlesGoogle scholar articles

Citation

Foster JB, Griffin C, Rokita JL, et al
Development of GPC2-directed chimeric antigen receptors using mRNA for pediatric brain tumors
Journal for ImmunoTherapy of Cancer 2022;10:e004450. doi: 10.1136/jitc-2021-004450
Online issue publication 
September 27, 2022

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© Author(s) (or their employer(s)) 2022. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ. http://creativecommons.org/licenses/by-nc/4.0/This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See http://creativecommons.org/licenses/by-nc/4.0/.