Article info

Original research
Chimeric antigen receptor T cells engineered to recognize the P329G-mutated Fc part of effector-silenced tumor antigen-targeting human IgG1 antibodies enable modular targeting of solid tumors

Authors

  • Sophia Stock Department of Medicine IV, Division of Clinical Pharmacology, University Hospital, Ludwig Maximilian University (LMU), Munich, GermanyDepartment of Medicine III, University Hospital, Ludwig Maximilian University (LMU), Munich, GermanyGerman Cancer Consortium (DKTK), Partner Site Munich, Munich, Germany PubMed articlesGoogle scholar articles
  • Mohamed-Reda Benmebarek Department of Medicine IV, Division of Clinical Pharmacology, University Hospital, Ludwig Maximilian University (LMU), Munich, GermanyNational Cancer Institute (NCI), Bethesda, Maryland, USA PubMed articlesGoogle scholar articles
  • Anna-Kristina Kluever Department of Medicine IV, Division of Clinical Pharmacology, University Hospital, Ludwig Maximilian University (LMU), Munich, Germany PubMed articlesGoogle scholar articles
  • Diana Darowski Roche Innovation Center Zurich, Roche Pharma Research & Early Development, Schlieren, SwitzerlandInnovent Biologics (Suzhou) Co., Ltd, Suzhou, Jiangsu, China PubMed articlesGoogle scholar articles
  • Christian Jost Roche Innovation Center Zurich, Roche Pharma Research & Early Development, Schlieren, SwitzerlandAthebio AG, Schlieren, Switzerland PubMed articlesGoogle scholar articles
  • Kay-Gunnar Stubenrauch Roche Innovation Center Munich, Penzberg, Germany PubMed articlesGoogle scholar articles
  • Joerg Benz Roche Innovation Center Basel, Basel, Switzerland PubMed articlesGoogle scholar articles
  • Anne Freimoser-Grundschober Roche Innovation Center Zurich, Roche Pharma Research & Early Development, Schlieren, Switzerland PubMed articlesGoogle scholar articles
  • Ekkehard Moessner Roche Innovation Center Zurich, Roche Pharma Research & Early Development, Schlieren, Switzerland PubMed articlesGoogle scholar articles
  • Pablo Umana Roche Innovation Center Zurich, Roche Pharma Research & Early Development, Schlieren, Switzerland PubMed articlesGoogle scholar articles
  • Marion Subklewe Department of Medicine III, University Hospital, Ludwig Maximilian University (LMU), Munich, GermanyGerman Cancer Consortium (DKTK), Partner Site Munich, Munich, Germany PubMed articlesGoogle scholar articles
  • Stefan Endres Department of Medicine IV, Division of Clinical Pharmacology, University Hospital, Ludwig Maximilian University (LMU), Munich, GermanyGerman Cancer Consortium (DKTK), Partner Site Munich, Munich, GermanyEinheit für Klinische Pharmakologie (EKLiP), Helmholtz Zentrum München, German Research Center for Environmental Health (HMGU), Neuherberg, Germany PubMed articlesGoogle scholar articles
  • Christian Klein Roche Innovation Center Zurich, Roche Pharma Research & Early Development, Schlieren, Switzerland PubMed articlesGoogle scholar articles
  • Sebastian Kobold Department of Medicine IV, Division of Clinical Pharmacology, University Hospital, Ludwig Maximilian University (LMU), Munich, GermanyGerman Cancer Consortium (DKTK), Partner Site Munich, Munich, GermanyEinheit für Klinische Pharmakologie (EKLiP), Helmholtz Zentrum München, German Research Center for Environmental Health (HMGU), Neuherberg, Germany PubMed articlesGoogle scholar articles

Citation

Stock S, Benmebarek M, Kluever A, et al
Chimeric antigen receptor T cells engineered to recognize the P329G-mutated Fc part of effector-silenced tumor antigen-targeting human IgG1 antibodies enable modular targeting of solid tumors
Online issue publication 
October 18, 2023

Request permissions

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.