Clinical outcome following checkpoint therapy in renal cell carcinoma is associated with a burst of activated CD8 T cells in blood

Jennifer Wilkinson Carlisle; Caroline S Jansen; Maria Andrea Cardenas; Ewelina Sobierajska; Adriana Moon Reyes; Rachel Greenwald; Luke Del Balzo; Nataliya Prokhnevska; Omer Kucuk; Bradley C Carthon; Patrick Connor Mullane; Adeboye Osunkoya; Deborah Baumgarten; Fares Hosseinzadeh; Scott Wilkinson; Ross Lake; Adam G Sowalsky; Yuan Liu; Viraj A Master; Mehmet A Bilen; Haydn Kissick

doi:10.1136/jitc-2022-004803

Article info

PDF

PDF +
Supplementary
Material

Immunotherapy biomarkers

Original research

Clinical outcome following checkpoint therapy in renal cell carcinoma is associated with a burst of activated CD8 T cells in blood

Authors

Jennifer Wilkinson Carlisle Department of Hematology and Medical Oncology, Emory University, Atlanta, Georgia, USAWinship Cancer Institute, Emory University, Atlanta, Georgia, USA PubMed articles Google scholar articles
Caroline S Jansen Winship Cancer Institute, Emory University, Atlanta, Georgia, USADepartment of Urology, Emory University, Atlanta, Georgia, USAVaccine Center, Emory University, Atlanta, Georgia, USA PubMed articles Google scholar articles
Maria Andrea Cardenas Department of Urology, Emory University, Atlanta, Georgia, USA PubMed articles Google scholar articles
Ewelina Sobierajska Department of Urology, Emory University, Atlanta, Georgia, USA PubMed articles Google scholar articles
Adriana Moon Reyes Department of Urology, Emory University, Atlanta, Georgia, USA PubMed articles Google scholar articles
Rachel Greenwald Department of Urology, Emory University, Atlanta, Georgia, USA PubMed articles Google scholar articles
Luke Del Balzo Department of Urology, Emory University, Atlanta, Georgia, USA PubMed articles Google scholar articles
Nataliya Prokhnevska Department of Urology, Emory University, Atlanta, Georgia, USA PubMed articles Google scholar articles
Omer Kucuk Winship Cancer Institute, Emory University, Atlanta, Georgia, USADepartment of Hematology and Medical Oncology, Emory University School of Medicine, Atlanta, Georgia, USA PubMed articles Google scholar articles
Bradley C Carthon Winship Cancer Institute, Emory University, Atlanta, Georgia, USADepartment of Hematology and Medical Oncology, Emory University School of Medicine, Atlanta, Georgia, USA PubMed articles Google scholar articles
Patrick Connor Mullane Department of Pathology, Emory University School of Medicine, Atlanta, Georgia, USA PubMed articles Google scholar articles
Adeboye Osunkoya Winship Cancer Institute, Emory University, Atlanta, Georgia, USADepartment of Urology, Emory University, Atlanta, Georgia, USADepartment of Pathology, Emory University School of Medicine, Atlanta, Georgia, USA PubMed articles Google scholar articles
Deborah Baumgarten Department of Radiology, Emory University School of Medicine, Atlanta, Georgia, USA PubMed articles Google scholar articles
Fares Hosseinzadeh Department of Urology, Emory University, Atlanta, Georgia, USA PubMed articles Google scholar articles
Scott Wilkinson Laboratory of Genitourinary Cancer Pathogenesis, National Cancer Institute, Bethesda, Maryland, USA PubMed articles Google scholar articles
Ross Lake Laboratory of Genitourinary Cancer Pathogenesis, National Cancer Institute, Bethesda, Maryland, USA PubMed articles Google scholar articles
Adam G Sowalsky Laboratory of Genitourinary Cancer Pathogenesis, National Cancer Institute, Bethesda, Maryland, USA PubMed articles Google scholar articles
Yuan Liu Departments of Biostatistics and Bioinformatics, Emory University, Atlanta, Georgia, USA PubMed articles Google scholar articles
Viraj A Master Winship Cancer Institute, Emory University, Atlanta, Georgia, USADepartment of Urology, Emory University, Atlanta, Georgia, USA PubMed articles Google scholar articles
Mehmet A Bilen Winship Cancer Institute, Emory University, Atlanta, Georgia, USADepartment of Hematology and Medical Oncology, Emory University School of Medicine, Atlanta, Georgia, USA PubMed articles Google scholar articles
Haydn Kissick Winship Cancer Institute, Emory University, Atlanta, Georgia, USADepartment of Urology, Emory University, Atlanta, Georgia, USAVaccine Center, Emory University, Atlanta, Georgia, USA PubMed articles Google scholar articles

Citation

Carlisle JW, Jansen CS, Cardenas MA, et al

Clinical outcome following checkpoint therapy in renal cell carcinoma is associated with a burst of activated CD8 T cells in blood

Journal for ImmunoTherapy of Cancer 2022;10:e004803. doi: 10.1136/jitc-2022-004803

Online issue publication

October 18, 2023

Request permissions

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.

Copyright information

© Author(s) (or their employer(s)) 2022. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ. http://creativecommons.org/licenses/by-nc/4.0/This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See http://creativecommons.org/licenses/by-nc/4.0/.

Log in using your username and password

Main menu

Log in using your username and password

You are here

Authors

Citation

Request permissions

Copyright information

Read the full text or download the PDF:

Log in using your username and password