Genome-scale CRISPR–Cas9 screen reveals novel regulators of B7-H3 in tumor cells

Shasha Zhao; Yuelong Wang; Nian Yang; Min Mu; Zhiguo Wu; Hexian Li; Xin Tang; Kunhong Zhong; Zongliang Zhang; Cheng Huang; Ting Cao; Meijun Zheng; Guoqing Wang; Chunlai Nie; Hui Yang; Gang Guo; Liangxue Zhou; Xi Zheng; Aiping Tong

doi:10.1136/jitc-2022-004875

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Basic tumor immunology

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Genome-scale CRISPR–Cas9 screen reveals novel regulators of B7-H3 in tumor cells

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Shasha Zhao State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, and Collaborative Innovation Center of Biotherapy, Sichuan University, Chengdu, Sichuan, China PubMed articles Google scholar articles
Yuelong Wang Department of Neurosurgery, West China Hospital, Sichuan University, Chengdu, Sichuan, China PubMed articles Google scholar articles
Nian Yang State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, and Collaborative Innovation Center of Biotherapy, Sichuan University, Chengdu, Sichuan, China PubMed articles Google scholar articles
Min Mu State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, and Collaborative Innovation Center of Biotherapy, Sichuan University, Chengdu, Sichuan, China PubMed articles Google scholar articles
Zhiguo Wu State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, and Collaborative Innovation Center of Biotherapy, Sichuan University, Chengdu, Sichuan, China PubMed articles Google scholar articles
Hexian Li State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, and Collaborative Innovation Center of Biotherapy, Sichuan University, Chengdu, Sichuan, China PubMed articles Google scholar articles
Xin Tang Department of Neurosurgery, West China Hospital, Sichuan University, Chengdu, Sichuan, China PubMed articles Google scholar articles
Kunhong Zhong State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, and Collaborative Innovation Center of Biotherapy, Sichuan University, Chengdu, Sichuan, China PubMed articles Google scholar articles
Zongliang Zhang State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, and Collaborative Innovation Center of Biotherapy, Sichuan University, Chengdu, Sichuan, China PubMed articles Google scholar articles
Cheng Huang State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, and Collaborative Innovation Center of Biotherapy, Sichuan University, Chengdu, Sichuan, China PubMed articles Google scholar articles
Ting Cao Lab of Infectious Diseases and Vaccine, West China Hospital, Sichuan University, Chengdu, Sichuan, China PubMed articles Google scholar articles
Meijun Zheng Department of Otolaryngology, Head and Neck Surgery, West China Hospital, Sichuan University, Chengdu, Sichuan, China PubMed articles Google scholar articles
Guoqing Wang Department of Neurosurgery, West China Hospital, Sichuan University, Chengdu, Sichuan, China PubMed articles Google scholar articles
Chunlai Nie State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, and Collaborative Innovation Center of Biotherapy, Sichuan University, Chengdu, Sichuan, China PubMed articles Google scholar articles
Hui Yang Department of Otolaryngology, Head and Neck Surgery, West China Hospital, Sichuan University, Chengdu, Sichuan, China PubMed articles Google scholar articles
Gang Guo State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, and Collaborative Innovation Center of Biotherapy, Sichuan University, Chengdu, Sichuan, China PubMed articles Google scholar articles
Liangxue Zhou Department of Neurosurgery, West China Hospital, Sichuan University, Chengdu, Sichuan, China PubMed articles Google scholar articles
Xi Zheng Lung Cancer Center, West China Hospital, Sichuan University, Chengdu, Sichuan, China PubMed articles Google scholar articles
Aiping Tong State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, and Collaborative Innovation Center of Biotherapy, Sichuan University, Chengdu, Sichuan, China PubMed articles Google scholar articles

Citation

Zhao S, Wang Y, Yang N, et al

Genome-scale CRISPR–Cas9 screen reveals novel regulators of B7-H3 in tumor cells

Journal for ImmunoTherapy of Cancer 2022;10:e004875. doi: 10.1136/jitc-2022-004875

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January 24, 2024

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© Author(s) (or their employer(s)) 2022. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ. http://creativecommons.org/licenses/by-nc/4.0/This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See http://creativecommons.org/licenses/by-nc/4.0/.

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