Intratumoral delivery of dendritic cells plus anti-HER2 therapy triggers both robust systemic antitumor immunity and complete regression in HER2 mammary carcinoma

Ganesan Ramamoorthi; Krithika Kodumudi; Colin Snyder; Payal Grover; Hongtao Zhang; Mark I Greene; Amrita Basu; Corey Gallen; Doris Wiener; Ricardo L B Costa; Hyo S Han; Gary Koski; Brian J Czerniecki

doi:10.1136/jitc-2022-004841

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Clinical/translational cancer immunotherapy

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Intratumoral delivery of dendritic cells plus anti-HER2 therapy triggers both robust systemic antitumor immunity and complete regression in HER2 mammary carcinoma

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Ganesan Ramamoorthi Clinical Science & Immunology Program, Moffitt Cancer Center, Tampa, Florida, USA PubMed articles Google scholar articles
Krithika Kodumudi Clinical Science & Immunology Program, Moffitt Cancer Center, Tampa, Florida, USA PubMed articles Google scholar articles
Colin Snyder Clinical Science & Immunology Program, Moffitt Cancer Center, Tampa, Florida, USA PubMed articles Google scholar articles
Payal Grover Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA PubMed articles Google scholar articles
Hongtao Zhang Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA PubMed articles Google scholar articles
Mark I Greene Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA PubMed articles Google scholar articles
Amrita Basu Clinical Science & Immunology Program, Moffitt Cancer Center, Tampa, Florida, USA PubMed articles Google scholar articles
Corey Gallen Clinical Science & Immunology Program, Moffitt Cancer Center, Tampa, Florida, USA PubMed articles Google scholar articles
Doris Wiener Clinical Science & Immunology Program, Moffitt Cancer Center, Tampa, Florida, USA PubMed articles Google scholar articles
Ricardo L B Costa Department of Breast Oncology, Moffitt Cancer Center, Tampa, Florida, USA PubMed articles Google scholar articles
Hyo S Han Department of Breast Oncology, Moffitt Cancer Center, Tampa, Florida, USA PubMed articles Google scholar articles
Gary Koski Biological Sciences, Kent State University, Kent, Ohio, USA PubMed articles Google scholar articles
Brian J Czerniecki Clinical Science & Immunology Program, Moffitt Cancer Center, Tampa, Florida, USADepartment of Breast Oncology, Moffitt Cancer Center, Tampa, Florida, USA PubMed articles Google scholar articles

Citation

Ramamoorthi G, Kodumudi K, Snyder C, et al

Intratumoral delivery of dendritic cells plus anti-HER2 therapy triggers both robust systemic antitumor immunity and complete regression in HER2 mammary carcinoma

Journal for ImmunoTherapy of Cancer 2022;10:e004841. doi: 10.1136/jitc-2022-004841

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January 24, 2024

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© Author(s) (or their employer(s)) 2022. Re-use permitted under CC BY. Published by BMJ. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed in accordance with the Creative Commons Attribution 4.0 Unported (CC BY 4.0) license, which permits others to copy, redistribute, remix, transform and build upon this work for any purpose, provided the original work is properly cited, a link to the licence is given, and indication of whether changes were made. See https://creativecommons.org/licenses/by/4.0/.

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