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Basic tumor immunology
Original research
Targeting of GSDMD sensitizes HCC to anti-PD-1 by activating cGAS pathway and downregulating PD-L1 expression

Authors

  • Tingting Lv Department of Gastroenterology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, Shandong, ChinaDepartment of Cancer Center, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, Shandong, China PubMed articlesGoogle scholar articles
  • Xiaofeng Xiong Tongji Hospital of Tongji Medical College of Huazhong University of Science and Technology, Wuhan, Hubei, China PubMed articlesGoogle scholar articles
  • Wei Yan Tongji Hospital of Tongji Medical College of Huazhong University of Science and Technology, Wuhan, Hubei, China PubMed articlesGoogle scholar articles
  • Mei Liu Tongji Hospital of Tongji Medical College of Huazhong University of Science and Technology, Wuhan, Hubei, China PubMed articlesGoogle scholar articles
  • Hongwei Xu Department of Gastroenterology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, Shandong, China PubMed articlesGoogle scholar articles
  • Qin He Department of Gastroenterology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, Shandong, China PubMed articlesGoogle scholar articles

Citation

Lv T, Xiong X, Yan W, et al
Targeting of GSDMD sensitizes HCC to anti-PD-1 by activating cGAS pathway and downregulating PD-L1 expression
Journal for ImmunoTherapy of Cancer 2022;10:e004763. doi: 10.1136/jitc-2022-004763
Online issue publication 
January 24, 2024

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© Author(s) (or their employer(s)) 2022. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ. http://creativecommons.org/licenses/by-nc/4.0/This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See http://creativecommons.org/licenses/by-nc/4.0/.