PD-L1 blockade restores CAR T cell activity through IFN-γ-regulation of CD163+ M2 macrophages

Yukiko Yamaguchi; Jackson Gibson; Kevin Ou; Lupita S Lopez; Rachel H Ng; Neena Leggett; Vanessa D Jonsson; Jelani C Zarif; Peter P Lee; Xiuli Wang; Catalina Martinez; Tanya B Dorff; Stephen J Forman; Saul J Priceman

doi:10.1136/jitc-2021-004400

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Immune cell therapies and immune cell engineering

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PD-L1 blockade restores CAR T cell activity through IFN-γ-regulation of CD163+ M2 macrophages

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Yukiko Yamaguchi Department of Hematology and Hematopoietic Cell Transplantation, City of Hope, Duarte, California, USA PubMed articles Google scholar articles
Jackson Gibson Department of Hematology and Hematopoietic Cell Transplantation, City of Hope, Duarte, California, USA PubMed articles Google scholar articles
Kevin Ou Department of Hematology and Hematopoietic Cell Transplantation, City of Hope, Duarte, California, USA PubMed articles Google scholar articles
Lupita S Lopez Department of Hematology and Hematopoietic Cell Transplantation, City of Hope, Duarte, California, USA PubMed articles Google scholar articles
Rachel H Ng Department of Hematology and Hematopoietic Cell Transplantation, City of Hope, Duarte, California, USADepartment of Bioengineering, University of Washington, Seattle, Washington, USA PubMed articles Google scholar articles
Neena Leggett Department of Hematology and Hematopoietic Cell Transplantation, City of Hope, Duarte, California, USA PubMed articles Google scholar articles
Vanessa D Jonsson Department of Applied Mathematics, University of California, Santa Cruz, California, USADepartment of Biomolecular Engineering, University of California, Santa Cruz, California, USA PubMed articles Google scholar articles
Jelani C Zarif Department of Oncology, Johns Hopkins University School of Medicine and The Sidney Kimmel Comprehensive Cancer Center, Baltimore, Maryland, USA PubMed articles Google scholar articles
Peter P Lee Department of Immuno-Oncology, Beckman Research Institute of City of Hope, Duarte, California, USA PubMed articles Google scholar articles
Xiuli Wang Department of Hematology and Hematopoietic Cell Transplantation, City of Hope, Duarte, California, USA PubMed articles Google scholar articles
Catalina Martinez Department of Clinical and Translational Project Development, City of Hope, Duarte, CA, USA PubMed articles Google scholar articles
Tanya B Dorff Department of Medical Oncology and Therapeutics Research, City of Hope National Medical Center, Duarte, California, USA PubMed articles Google scholar articles
Stephen J Forman Department of Hematology and Hematopoietic Cell Transplantation, City of Hope, Duarte, California, USADepartment of Immuno-Oncology, Beckman Research Institute of City of Hope, Duarte, California, USA PubMed articles Google scholar articles
Saul J Priceman Department of Hematology and Hematopoietic Cell Transplantation, City of Hope, Duarte, California, USADepartment of Immuno-Oncology, Beckman Research Institute of City of Hope, Duarte, California, USA PubMed articles Google scholar articles

Citation

Yamaguchi Y, Gibson J, Ou K, et al

PD-L1 blockade restores CAR T cell activity through IFN-γ-regulation of CD163+ M2 macrophages

Journal for ImmunoTherapy of Cancer 2022;10:e004400. doi: 10.1136/jitc-2021-004400

Online issue publication

January 24, 2024

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© Author(s) (or their employer(s)) 2022. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ. http://creativecommons.org/licenses/by-nc/4.0/This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See http://creativecommons.org/licenses/by-nc/4.0/.

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