Increase in serum choline levels predicts for improved progression-free survival (PFS) in patients with advanced cancers receiving pembrolizumab

Geoffrey Alan Watson; Enrique Sanz-Garcia; Wen-Jiang Zhang; Zhihui Amy Liu; SY Cindy Yang; Ben Wang; Shaofeng Liu; Shawn Kubli; Hal Berman; Thomas Pfister; Sofia Genta; Anna Spreafico; Aaron R Hansen; Philippe L Bedard; Stephanie Lheureux; Albiruni Abdul Razak; Dave Cescon; Marcus O Butler; Wei Xu; Tak W Mak; Lillian L Siu; Eric Chen

doi:10.1136/jitc-2021-004378

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Immunotherapy biomarkers

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Increase in serum choline levels predicts for improved progression-free survival (PFS) in patients with advanced cancers receiving pembrolizumab

Authors

Geoffrey Alan Watson Division of Medical Oncology and Hematology, University Health Network, Princess Margaret Cancer Centre, Toronto, Ontario, Canada PubMed articles Google scholar articles
Enrique Sanz-Garcia Division of Medical Oncology and Hematology, University Health Network, Princess Margaret Cancer Centre, Toronto, Ontario, Canada PubMed articles Google scholar articles
Wen-Jiang Zhang Division of Medical Oncology and Hematology, University Health Network, Princess Margaret Cancer Centre, Toronto, Ontario, Canada PubMed articles Google scholar articles
Zhihui Amy Liu Biostatistics, Princess Margaret Hospital Cancer Centre, Toronto, Ontario, CanadaUniversity of Toronto Dalla Lana School of Public Health, Toronto, Ontario, Canada PubMed articles Google scholar articles
SY Cindy Yang Medical Biophysics, University of Toronto, Toronto, Ontario, Canada PubMed articles Google scholar articles
Ben Wang Laboratory Medicine and Pathobiology, University Health Network, Princess Margaret Cancer Centre, Toronto, Ontario, Canada PubMed articles Google scholar articles
Shaofeng Liu Immunology, University of Toronto, Toronto, Ontario, Canada PubMed articles Google scholar articles
Shawn Kubli Immunology, University of Toronto, Toronto, Ontario, Canada PubMed articles Google scholar articles
Hal Berman Laboratory Medicine and Pathobiology, University Health Network, Princess Margaret Cancer Centre, Toronto, Ontario, Canada PubMed articles Google scholar articles
Thomas Pfister Laboratory Medicine and Pathobiology, University Health Network, Princess Margaret Cancer Centre, Toronto, Ontario, Canada PubMed articles Google scholar articles
Sofia Genta Division of Medical Oncology and Hematology, University Health Network, Princess Margaret Cancer Centre, Toronto, Ontario, Canada PubMed articles Google scholar articles
Anna Spreafico Division of Medical Oncology and Hematology, University Health Network, Princess Margaret Cancer Centre, Toronto, Ontario, Canada PubMed articles Google scholar articles
Aaron R Hansen Division of Medical Oncology and Hematology, University Health Network, Princess Margaret Cancer Centre, Toronto, Ontario, Canada PubMed articles Google scholar articles
Philippe L Bedard Division of Medical Oncology and Hematology, University Health Network, Princess Margaret Cancer Centre, Toronto, Ontario, Canada PubMed articles Google scholar articles
Stephanie Lheureux Division of Medical Oncology and Hematology, University Health Network, Princess Margaret Cancer Centre, Toronto, Ontario, Canada PubMed articles Google scholar articles
Albiruni Abdul Razak Division of Medical Oncology and Hematology, University Health Network, Princess Margaret Cancer Centre, Toronto, Ontario, Canada PubMed articles Google scholar articles
Dave Cescon Division of Medical Oncology and Hematology, University Health Network, Princess Margaret Cancer Centre, Toronto, Ontario, Canada PubMed articles Google scholar articles
Marcus O Butler Division of Medical Oncology and Hematology, University Health Network, Princess Margaret Cancer Centre, Toronto, Ontario, Canada PubMed articles Google scholar articles
Wei Xu Biostatistics, Princess Margaret Hospital Cancer Centre, Toronto, Ontario, Canada PubMed articles Google scholar articles
Tak W Mak Immunology, University of Toronto, Toronto, Ontario, Canada PubMed articles Google scholar articles
Lillian L Siu Division of Medical Oncology and Hematology, University Health Network, Princess Margaret Cancer Centre, Toronto, Ontario, Canada PubMed articles Google scholar articles
Eric Chen Division of Medical Oncology and Hematology, University Health Network, Princess Margaret Cancer Centre, Toronto, Ontario, Canada PubMed articles Google scholar articles

Citation

Watson GA, Sanz-Garcia E, Zhang W, et al

Increase in serum choline levels predicts for improved progression-free survival (PFS) in patients with advanced cancers receiving pembrolizumab

Journal for ImmunoTherapy of Cancer 2022;10:e004378. doi: 10.1136/jitc-2021-004378

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January 24, 2024

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© Author(s) (or their employer(s)) 2022. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ. http://creativecommons.org/licenses/by-nc/4.0/This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See http://creativecommons.org/licenses/by-nc/4.0/.

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