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Clinical/translational cancer immunotherapy
Efficacy of second CAR-T (CART2) infusion limited by poor CART expansion and antigen modulation

Authors

  • Elizabeth M Holland Pediatric Oncology Branch, Center for Cancer Research, National Cancer Institute, National Insitutes of Health, Bethesda, Maryland, USA PubMed articlesGoogle scholar articles
  • John C Molina Pediatric Oncology Branch, Center for Cancer Research, National Cancer Institute, National Insitutes of Health, Bethesda, Maryland, USADepartment of Pediatric Oncology, Johns Hopkins Hospital, Baltimore, Maryland, USA PubMed articlesGoogle scholar articles
  • Kniya Dede Pediatric Oncology Branch, Center for Cancer Research, National Cancer Institute, National Insitutes of Health, Bethesda, Maryland, USA PubMed articlesGoogle scholar articles
  • Daniel Moyer Laboratory of Pathology, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA PubMed articlesGoogle scholar articles
  • Ting Zhou Laboratory of Pathology, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA PubMed articlesGoogle scholar articles
  • Constance M Yuan Laboratory of Pathology, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA PubMed articlesGoogle scholar articles
  • Hao-Wei Wang Laboratory of Pathology, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA PubMed articlesGoogle scholar articles
  • Maryalice Stetler-Stevenson Laboratory of Pathology, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA PubMed articlesGoogle scholar articles
  • Crystal Mackall Pediatric Oncology Branch, Center for Cancer Research, National Cancer Institute, National Insitutes of Health, Bethesda, Maryland, USACenter for Cancer Cell Therapy, Stanford Cancer Institute, Stanford University, Stanford, California, USADivision of Hematology/Oncology/SCT and Regenerative Medicine, Department of Pediatrics, Stanford University, Stanford, California, USADivision of Stem Cell Transplant and Cell Therapy, Department of Medicine, Stanford, California, USA PubMed articlesGoogle scholar articles
  • Terry J Fry Pediatric Oncology Branch, Center for Cancer Research, National Cancer Institute, National Insitutes of Health, Bethesda, Maryland, USAUniversity of Colorado Anschutz Medical Campus and Center for Cancer and Blood Disorders, Children’s Hospital of Colorado, Aurora, Colorado, USA PubMed articlesGoogle scholar articles
  • Sandhya Panch Center for Cellular Engineering, Department of Laboratory Medicine, National Institutes of Health Clinical Center, Bethesda, Maryland, USA PubMed articlesGoogle scholar articles
  • Steven Highfill Center for Cellular Engineering, Department of Laboratory Medicine, National Institutes of Health Clinical Center, Bethesda, Maryland, USA PubMed articlesGoogle scholar articles
  • David Stroncek Center for Cellular Engineering, Department of Laboratory Medicine, National Institutes of Health Clinical Center, Bethesda, Maryland, USA PubMed articlesGoogle scholar articles
  • Lauren Little Pediatric Oncology Branch, Center for Cancer Research, National Cancer Institute, National Insitutes of Health, Bethesda, Maryland, USA PubMed articlesGoogle scholar articles
  • Daniel W Lee Pediatric Oncology Branch, Center for Cancer Research, National Cancer Institute, National Insitutes of Health, Bethesda, Maryland, USADivision of Pediatric Hematology/Oncology, Department of Pediatrics, University of Virginia, Charlottesville, Virginia, USA PubMed articlesGoogle scholar articles
  • Haneen Shalabi Pediatric Oncology Branch, Center for Cancer Research, National Cancer Institute, National Insitutes of Health, Bethesda, Maryland, USA PubMed articlesGoogle scholar articles
  • Bonnie Yates Pediatric Oncology Branch, Center for Cancer Research, National Cancer Institute, National Insitutes of Health, Bethesda, Maryland, USA PubMed articlesGoogle scholar articles
  • Nirali Shah Pediatric Oncology Branch, Center for Cancer Research, National Cancer Institute, National Insitutes of Health, Bethesda, Maryland, USA PubMed articlesGoogle scholar articles

Citation

Holland EM, Molina JC, Dede K, et al
Efficacy of second CAR-T (CART2) infusion limited by poor CART expansion and antigen modulation
Journal for ImmunoTherapy of Cancer 2022;10:e004483. doi: 10.1136/jitc-2021-004483
Online issue publication 
May 09, 2022

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Copyright information

© Author(s) (or their employer(s)) 2022. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ. http://creativecommons.org/licenses/by-nc/4.0/This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See http://creativecommons.org/licenses/by-nc/4.0/.