CD4 T cell dynamics shape the immune response to combination oncolytic herpes virus and BRAF inhibitor therapy for melanoma

Galabina Bozhanova; Jehanne Hassan; Lizzie Appleton; Victoria Jennings; Shane Foo; Martin McLaughlin; Charleen ML Chan Wah Hak; Emmanuel C Patin; Eva Crespo-Rodriguez; Gabby Baker; Edward Armstrong; Matthew Chiu; Hardev Pandha; Adel Samson; Victoria Roulstone; Joan Kyula; Richard Vile; Fiona Errington-Mais; Malin Pedersen; Kevin Harrington; Masahiro Ono; Alan Melcher

doi:10.1136/jitc-2021-004410

Article info

Oncolytic and local immunotherapy

Original research

CD4 T cell dynamics shape the immune response to combination oncolytic herpes virus and BRAF inhibitor therapy for melanoma

Authors

Galabina Bozhanova Translational Immunotherapy/Targeted Therapy Teams, The Institute of Cancer Research, London, UK PubMed articles Google scholar articles
Jehanne Hassan Imperial College London, London, UK PubMed articles Google scholar articles
Lizzie Appleton Translational Immunotherapy/Targeted Therapy Teams, The Institute of Cancer Research, London, UKImperial College London, London, UK PubMed articles Google scholar articles
Victoria Jennings Leeds Institute of Medical Research at St. James’s, University of Leeds, Leeds, UK PubMed articles Google scholar articles
Shane Foo Radiotherapy & Imaging, The Institute of Cancer Research, London, UK PubMed articles Google scholar articles
Martin McLaughlin Institute of Cancer Research, London, UK PubMed articles Google scholar articles
Charleen ML Chan Wah Hak Translational Immunotherapy/Targeted Therapy Teams, The Institute of Cancer Research, London, UK PubMed articles Google scholar articles
Emmanuel C Patin Translational Immunotherapy/Targeted Therapy Teams, The Institute of Cancer Research, London, UK PubMed articles Google scholar articles
Eva Crespo-Rodriguez Translational Immunotherapy/Targeted Therapy Teams, The Institute of Cancer Research, London, UK PubMed articles Google scholar articles
Gabby Baker Translational Immunotherapy/Targeted Therapy Teams, The Institute of Cancer Research, London, UK PubMed articles Google scholar articles
Edward Armstrong Translational Immunotherapy/Targeted Therapy Teams, The Institute of Cancer Research, London, UK PubMed articles Google scholar articles
Matthew Chiu Translational Immunotherapy/Targeted Therapy Teams, The Institute of Cancer Research, London, UK PubMed articles Google scholar articles
Hardev Pandha Oncology, University of Surrey, Guildford, UK PubMed articles Google scholar articles
Adel Samson Leeds Institute of Medical Research at St. James’s, University of Leeds, Leeds, UK PubMed articles Google scholar articles
Victoria Roulstone Translational Immunotherapy/Targeted Therapy Teams, The Institute of Cancer Research, London, UK PubMed articles Google scholar articles
Joan Kyula Translational Immunotherapy/Targeted Therapy Teams, The Institute of Cancer Research, London, UK PubMed articles Google scholar articles
Richard Vile Molecular Medicine, Mayo Clinic, Rochester, Minnesota, USA PubMed articles Google scholar articles
Fiona Errington-Mais Leeds Institute of Medical Research at St. James’s, University of Leeds, Leeds, UK PubMed articles Google scholar articles
Malin Pedersen Translational Immunotherapy/Targeted Therapy Teams, The Institute of Cancer Research, London, UK PubMed articles Google scholar articles
Kevin Harrington Division of Radiotherapy and Imaging, The Institute of Cancer Research, London, UK PubMed articles Google scholar articles
Masahiro Ono Imperial College London, London, UK PubMed articles Google scholar articles
Alan Melcher Institute of Cancer Research, London, UK PubMed articles Google scholar articles

Citation

Bozhanova G, Hassan J, Appleton L, et al

CD4 T cell dynamics shape the immune response to combination oncolytic herpes virus and BRAF inhibitor therapy for melanoma

Journal for ImmunoTherapy of Cancer 2022;10:e004410. doi: 10.1136/jitc-2021-004410

Online issue publication

October 18, 2023

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© Author(s) (or their employer(s)) 2022. Re-use permitted under CC BY. Published by BMJ. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed in accordance with the Creative Commons Attribution 4.0 Unported (CC BY 4.0) license, which permits others to copy, redistribute, remix, transform and build upon this work for any purpose, provided the original work is properly cited, a link to the licence is given, and indication of whether changes were made. See https://creativecommons.org/licenses/by/4.0/.

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