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Basic tumor immunology
Original research
STAT3 inhibitor Napabucasin abrogates MDSC immunosuppressive capacity and prolongs survival of melanoma-bearing mice

Authors

  • Rebekka Bitsch Skin Cancer Unit/ Department of Dermatology, Venerology and Allergology, German Cancer Research Center (DKFZ), University Medical Centre Mannheim, Heidelberg, Mannheim, GermanyMannheim Institute for Innate Immunoscience (MI3), Medical Faculty Mannheim, Ruprecht-Karl University of Heidelberg, Mannheim, GermanyDKFZ-Hector Cancer Institute, University Medical Centre Mannheim, Mannheim, Germany PubMed articlesGoogle scholar articles
  • Annina Kurzay Skin Cancer Unit/ Department of Dermatology, Venerology and Allergology, German Cancer Research Center (DKFZ), University Medical Centre Mannheim, Heidelberg, Mannheim, GermanyMannheim Institute for Innate Immunoscience (MI3), Medical Faculty Mannheim, Ruprecht-Karl University of Heidelberg, Mannheim, GermanyDKFZ-Hector Cancer Institute, University Medical Centre Mannheim, Mannheim, Germany PubMed articlesGoogle scholar articles
  • Feyza Özbay Kurt Skin Cancer Unit/ Department of Dermatology, Venerology and Allergology, German Cancer Research Center (DKFZ), University Medical Centre Mannheim, Heidelberg, Mannheim, GermanyMannheim Institute for Innate Immunoscience (MI3), Medical Faculty Mannheim, Ruprecht-Karl University of Heidelberg, Mannheim, GermanyDKFZ-Hector Cancer Institute, University Medical Centre Mannheim, Mannheim, GermanyFaculty of Biosciences, Ruprecht-Karl University of Heidelberg, Heidelberg, Germany PubMed articlesGoogle scholar articles
  • Carolina De La Torre NGS Core Facility, Medical Faculty Mannheim, Ruprecht-Karl University of Heidelberg, Mannheim, Germany PubMed articlesGoogle scholar articles
  • Samantha Lasser Skin Cancer Unit/ Department of Dermatology, Venerology and Allergology, German Cancer Research Center (DKFZ), University Medical Centre Mannheim, Heidelberg, Mannheim, GermanyMannheim Institute for Innate Immunoscience (MI3), Medical Faculty Mannheim, Ruprecht-Karl University of Heidelberg, Mannheim, GermanyDKFZ-Hector Cancer Institute, University Medical Centre Mannheim, Mannheim, GermanyFaculty of Biosciences, Ruprecht-Karl University of Heidelberg, Heidelberg, Germany PubMed articlesGoogle scholar articles
  • Alisa Lepper Skin Cancer Unit/ Department of Dermatology, Venerology and Allergology, German Cancer Research Center (DKFZ), University Medical Centre Mannheim, Heidelberg, Mannheim, GermanyMannheim Institute for Innate Immunoscience (MI3), Medical Faculty Mannheim, Ruprecht-Karl University of Heidelberg, Mannheim, GermanyDKFZ-Hector Cancer Institute, University Medical Centre Mannheim, Mannheim, Germany PubMed articlesGoogle scholar articles
  • Alina Siebenmorgen Skin Cancer Unit/ Department of Dermatology, Venerology and Allergology, German Cancer Research Center (DKFZ), University Medical Centre Mannheim, Heidelberg, Mannheim, GermanyMannheim Institute for Innate Immunoscience (MI3), Medical Faculty Mannheim, Ruprecht-Karl University of Heidelberg, Mannheim, GermanyDKFZ-Hector Cancer Institute, University Medical Centre Mannheim, Mannheim, Germany PubMed articlesGoogle scholar articles
  • Verena Müller Skin Cancer Unit/ Department of Dermatology, Venerology and Allergology, German Cancer Research Center (DKFZ), University Medical Centre Mannheim, Heidelberg, Mannheim, Germany PubMed articlesGoogle scholar articles
  • Peter Altevogt Skin Cancer Unit/ Department of Dermatology, Venerology and Allergology, German Cancer Research Center (DKFZ), University Medical Centre Mannheim, Heidelberg, Mannheim, GermanyMannheim Institute for Innate Immunoscience (MI3), Medical Faculty Mannheim, Ruprecht-Karl University of Heidelberg, Mannheim, GermanyDKFZ-Hector Cancer Institute, University Medical Centre Mannheim, Mannheim, Germany PubMed articlesGoogle scholar articles
  • Jochen Utikal Skin Cancer Unit/ Department of Dermatology, Venerology and Allergology, German Cancer Research Center (DKFZ), University Medical Centre Mannheim, Heidelberg, Mannheim, GermanyDKFZ-Hector Cancer Institute, University Medical Centre Mannheim, Mannheim, Germany PubMed articlesGoogle scholar articles
  • Viktor Umansky Skin Cancer Unit/ Department of Dermatology, Venerology and Allergology, German Cancer Research Center (DKFZ), University Medical Centre Mannheim, Heidelberg, Mannheim, GermanyMannheim Institute for Innate Immunoscience (MI3), Medical Faculty Mannheim, Ruprecht-Karl University of Heidelberg, Mannheim, GermanyDKFZ-Hector Cancer Institute, University Medical Centre Mannheim, Mannheim, Germany PubMed articlesGoogle scholar articles

Citation

Bitsch R, Kurzay A, Özbay Kurt F, et al
STAT3 inhibitor Napabucasin abrogates MDSC immunosuppressive capacity and prolongs survival of melanoma-bearing mice
Journal for ImmunoTherapy of Cancer 2022;10:e004384. doi: 10.1136/jitc-2021-004384
Online issue publication 
October 18, 2023

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© Author(s) (or their employer(s)) 2022. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ. http://creativecommons.org/licenses/by-nc/4.0/This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See http://creativecommons.org/licenses/by-nc/4.0/.