Harnessing radiotherapy-induced NK-cell activity by combining DNA damage–response inhibition and immune checkpoint blockade

Emmanuel C Patin; Magnus T Dillon; Pablo Nenclares; Lorna Grove; Heba Soliman; Isla Leslie; Davina Northcote; Galabina Bozhanova; Eva Crespo-Rodriguez; Holly Baldock; Harriet Whittock; Gabriella Baker; Joan Kyula; Jeane Guevara; Alan A Melcher; James Harper; Hormas Ghadially; Simon Smith; Malin Pedersen; Martin McLaughlin; Kevin J Harrington

doi:10.1136/jitc-2021-004306

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Clinical/translational cancer immunotherapy

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Harnessing radiotherapy-induced NK-cell activity by combining DNA damage–response inhibition and immune checkpoint blockade

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Emmanuel C Patin Division of Radiotherapy and Imaging, The Institute of Cancer Research, London, UK PubMed articles Google scholar articles
Magnus T Dillon Division of Radiotherapy and Imaging, The Institute of Cancer Research, London, UK PubMed articles Google scholar articles
Pablo Nenclares Division of Radiotherapy and Imaging, The Institute of Cancer Research, London, UKHead and Neck Unit, Royal Marsden Hospital NHS Trust, London, UK PubMed articles Google scholar articles
Lorna Grove Division of Radiotherapy and Imaging, The Institute of Cancer Research, London, UKHead and Neck Unit, Royal Marsden Hospital NHS Trust, London, UK PubMed articles Google scholar articles
Heba Soliman Head and Neck Unit, Royal Marsden Hospital NHS Trust, London, UK PubMed articles Google scholar articles
Isla Leslie Head and Neck Unit, Royal Marsden Hospital NHS Trust, London, UK PubMed articles Google scholar articles
Davina Northcote Head and Neck Unit, Royal Marsden Hospital NHS Trust, London, UK PubMed articles Google scholar articles
Galabina Bozhanova Division of Radiotherapy and Imaging, The Institute of Cancer Research, London, UK PubMed articles Google scholar articles
Eva Crespo-Rodriguez Division of Radiotherapy and Imaging, The Institute of Cancer Research, London, UK PubMed articles Google scholar articles
Holly Baldock Biological Services Unit, The Institute of Cancer Research, London, UK PubMed articles Google scholar articles
Harriet Whittock Biological Services Unit, The Institute of Cancer Research, London, UK PubMed articles Google scholar articles
Gabriella Baker Division of Radiotherapy and Imaging, The Institute of Cancer Research, London, UK PubMed articles Google scholar articles
Joan Kyula Division of Radiotherapy and Imaging, The Institute of Cancer Research, London, UK PubMed articles Google scholar articles
Jeane Guevara Head and Neck Unit, Royal Marsden Hospital NHS Trust, London, UK PubMed articles Google scholar articles
Alan A Melcher Division of Radiotherapy and Imaging, The Institute of Cancer Research, London, UK PubMed articles Google scholar articles
James Harper Early Oncology R&D, AstraZeneca, Cambridge, UK PubMed articles Google scholar articles
Hormas Ghadially Early Oncology R&D, AstraZeneca, Cambridge, UK PubMed articles Google scholar articles
Simon Smith Early Oncology R&D, AstraZeneca, Cambridge, UK PubMed articles Google scholar articles
Malin Pedersen Division of Radiotherapy and Imaging, The Institute of Cancer Research, London, UK PubMed articles Google scholar articles
Martin McLaughlin Division of Radiotherapy and Imaging, The Institute of Cancer Research, London, UK PubMed articles Google scholar articles
Kevin J Harrington Division of Radiotherapy and Imaging, The Institute of Cancer Research, London, UKHead and Neck Unit, Royal Marsden Hospital NHS Trust, London, UK PubMed articles Google scholar articles

Citation

Patin EC, Dillon MT, Nenclares P, et al

Harnessing radiotherapy-induced NK-cell activity by combining DNA damage–response inhibition and immune checkpoint blockade

Journal for ImmunoTherapy of Cancer 2022;10:e004306. doi: 10.1136/jitc-2021-004306

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October 18, 2023

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© Author(s) (or their employer(s)) 2022. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ. http://creativecommons.org/licenses/by-nc/4.0/This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See http://creativecommons.org/licenses/by-nc/4.0/.

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