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Basic tumor immunology
Original research
PI3K activation allows immune evasion by promoting an inhibitory myeloid tumor microenvironment

Authors

  • Natalie B Collins Department of Pediatric Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, USADana-Farber/Boston Children's Cancer and Blood Disorders Center, Boston Children's Hospital, Boston, Massachusetts, USA PubMed articlesGoogle scholar articles
  • Rose Al Abosy Department of Pediatric Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, USA PubMed articlesGoogle scholar articles
  • Brian C Miller Lineberger Comprehensive Cancer Center, Department of Medicine, Division of Oncology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA PubMed articlesGoogle scholar articles
  • Kevin Bi Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, USA PubMed articlesGoogle scholar articles
  • Qihong Zhao Oncology Discovery Biology, Bristol Myers Squibb, Lawrenceville, New Jersey, USA PubMed articlesGoogle scholar articles
  • Michael Quigley Research Biology, Gilead Sciences Inc, Foster City, California, USA PubMed articlesGoogle scholar articles
  • Jeffrey J Ishizuka Department of Internal Medicine (Oncology), Yale Cancer Center and Yale School of Medicine, New Haven, New Jersey, USA PubMed articlesGoogle scholar articles
  • Kathleen B Yates Broad Institute, Cambridge, Massachusetts, USACenter for Cancer Research, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts, USA PubMed articlesGoogle scholar articles
  • Hans W Pope Arsenal Biosciences, San Francisco, California, USA PubMed articlesGoogle scholar articles
  • Robert T Manguso Broad Institute, Cambridge, Massachusetts, USACenter for Cancer Research, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts, USA PubMed articlesGoogle scholar articles
  • Yashaswi Shrestha AstraZeneca, Gaithersburg, Maryland, USA PubMed articlesGoogle scholar articles
  • Marc Wadsworth Broad Institute, Cambridge, Massachusetts, USAInstitute for Medical Engineering & Science (IMES), Department of Chemistry and Koch Institute for Integrative Cancer Research, Ragon Institute, Massachusetts Institute of Technology, Cambridge, Massachusetts, USARagon Institute of MGH, MIT and Harvard, Boston, Massachusetts, USA PubMed articlesGoogle scholar articles
  • Travis Hughes Broad Institute, Cambridge, Massachusetts, USAInstitute for Medical Engineering & Science (IMES), Department of Chemistry and Koch Institute for Integrative Cancer Research, Ragon Institute, Massachusetts Institute of Technology, Cambridge, Massachusetts, USARagon Institute of MGH, MIT and Harvard, Boston, Massachusetts, USA PubMed articlesGoogle scholar articles
  • Alex K Shalek Broad Institute, Cambridge, Massachusetts, USAInstitute for Medical Engineering & Science (IMES), Department of Chemistry and Koch Institute for Integrative Cancer Research, Ragon Institute, Massachusetts Institute of Technology, Cambridge, Massachusetts, USARagon Institute of MGH, MIT and Harvard, Boston, Massachusetts, USA PubMed articlesGoogle scholar articles
  • Jesse S Boehm Broad Institute, Cambridge, Massachusetts, USA PubMed articlesGoogle scholar articles
  • William C Hahn Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, USABroad Institute, Cambridge, Massachusetts, USADepartment of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA PubMed articlesGoogle scholar articles
  • John G Doench Broad Institute, Cambridge, Massachusetts, USA PubMed articlesGoogle scholar articles
  • W Nicholas Haining Arsenal Biosciences, San Francisco, California, USA PubMed articlesGoogle scholar articles

Citation

Collins NB, Al Abosy R, Miller BC, et al
PI3K activation allows immune evasion by promoting an inhibitory myeloid tumor microenvironment
Journal for ImmunoTherapy of Cancer 2022;10:e003402. doi: 10.1136/jitc-2021-003402
Online issue publication 
October 18, 2023

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© Author(s) (or their employer(s)) 2022. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ. http://creativecommons.org/licenses/by-nc/4.0/This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See http://creativecommons.org/licenses/by-nc/4.0/.