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Immune cell therapies and immune cell engineering
Original research
Delivery of CD47 blocker SIRPα-Fc by CAR-T cells enhances antitumor efficacy

Authors

  • Huanpeng Chen BioResource Research Center, Key Laboratory for Major Obstetric Diseases of Guangdong Province, The Third Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong, ChinaInstitute of Human Virology, Sun Yat-sen University Zhongshan School of Medicine, Guangzhou, Guangdong, China PubMed articlesGoogle scholar articles
  • Yuying Yang Institute of Human Virology, Sun Yat-sen University Zhongshan School of Medicine, Guangzhou, Guangdong, ChinaKey Laboratory of Tropical Disease Control, Sun Yat-Sen University, Guangzhou, Guangdong, China PubMed articlesGoogle scholar articles
  • Yuqing Deng Faculty of Science, Monash University, Clayton, Victoria, Australia PubMed articlesGoogle scholar articles
  • Fengjiao Wei Institute of Human Virology, Sun Yat-sen University Zhongshan School of Medicine, Guangzhou, Guangdong, ChinaKey Laboratory of Tropical Disease Control, Sun Yat-Sen University, Guangzhou, Guangdong, China PubMed articlesGoogle scholar articles
  • Qingyu Zhao ICU, Sun Yat-sen University Cancer Center, Guangzhou, Guangdong, China PubMed articlesGoogle scholar articles
  • Yongqi Liu Laboratory Animal Center, South China Agricultural University, Guangzhou, Guangdong, China PubMed articlesGoogle scholar articles
  • Zhonghua Liu Laboratory Animal Center, South China Agricultural University, Guangzhou, Guangdong, China PubMed articlesGoogle scholar articles
  • Bolan Yu BioResource Research Center, Key Laboratory for Major Obstetric Diseases of Guangdong Province, The Third Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong, China PubMed articlesGoogle scholar articles
  • Zhaofeng Huang Institute of Human Virology, Sun Yat-sen University Zhongshan School of Medicine, Guangzhou, Guangdong, ChinaKey Laboratory of Tropical Disease Control, Sun Yat-Sen University, Guangzhou, Guangdong, China PubMed articlesGoogle scholar articles

Citation

Chen H, Yang Y, Deng Y, et al
Delivery of CD47 blocker SIRPα-Fc by CAR-T cells enhances antitumor efficacy
Journal for ImmunoTherapy of Cancer 2022;10:e003737. doi: 10.1136/jitc-2021-003737
Online issue publication 
October 18, 2023

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Copyright information

© Author(s) (or their employer(s)) 2022. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ. http://creativecommons.org/licenses/by-nc/4.0/This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See http://creativecommons.org/licenses/by-nc/4.0/.