Combined IL-2, agonistic CD3 and 4-1BB stimulation preserve clonotype hierarchy in propagated non-small cell lung cancer tumor-infiltrating lymphocytes

Parin Shah; Marie-Andrée Forget; Meredith L Frank; Peixin Jiang; Donastas Sakellariou-Thompson; Lorenzo Federico; Roohussaba Khairullah; Chantal Alexia Neutzler; Ignacio Wistuba; Chi-Wan B Chow; Yan Long; Junya Fujimoto; Shiaw-Yih Lin; Anirban Maitra; Marcelo V Negrao; Kyle Gregory Mitchell; Annikka Weissferdt; Ara A Vaporciyan; Tina Cascone; Jack A Roth; Jianjun Zhang; Boris Sepesi; Don L Gibbons; John V Heymach; Cara L Haymaker; Daniel J McGrail; Alexandre Reuben; Chantale Bernatchez

doi:10.1136/jitc-2021-003082

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Immune cell therapies and immune cell engineering

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Combined IL-2, agonistic CD3 and 4-1BB stimulation preserve clonotype hierarchy in propagated non-small cell lung cancer tumor-infiltrating lymphocytes

Authors

Parin Shah Melanoma Medical Oncology, University of Texas MD Anderson Cancer Center, Houston, Texas, USA PubMed articles Google scholar articles
Marie-Andrée Forget Melanoma Medical Oncology, University of Texas MD Anderson Cancer Center, Houston, Texas, USABiologics Development, University of Texas MD Anderson Cancer Center, Houston, Texas, USA PubMed articles Google scholar articles
Meredith L Frank Thoracic/Head and Neck Medical Oncology, University of Texas MD Anderson Cancer Center, Houston, Texas, USA PubMed articles Google scholar articles
Peixin Jiang Thoracic/Head and Neck Medical Oncology, University of Texas MD Anderson Cancer Center, Houston, Texas, USA PubMed articles Google scholar articles
Donastas Sakellariou-Thompson Biologics Development, University of Texas MD Anderson Cancer Center, Houston, Texas, USA PubMed articles Google scholar articles
Lorenzo Federico Melanoma Medical Oncology, University of Texas MD Anderson Cancer Center, Houston, Texas, USA PubMed articles Google scholar articles
Roohussaba Khairullah Thoracic/Head and Neck Medical Oncology, University of Texas MD Anderson Cancer Center, Houston, Texas, USA PubMed articles Google scholar articles
Chantal Alexia Neutzler Biologics Development, University of Texas MD Anderson Cancer Center, Houston, Texas, USA PubMed articles Google scholar articles
Ignacio Wistuba Thoracic/Head and Neck Medical Oncology, University of Texas MD Anderson Cancer Center, Houston, Texas, USADepartment of Translational Molecular Pathology, University of Texas MD Anderson Cancer Center, Houston, Texas, USA PubMed articles Google scholar articles
Chi-Wan B Chow Department of Translational Molecular Pathology, University of Texas MD Anderson Cancer Center, Houston, Texas, USA PubMed articles Google scholar articles
Yan Long Department of Translational Molecular Pathology, University of Texas MD Anderson Cancer Center, Houston, Texas, USA PubMed articles Google scholar articles
Junya Fujimoto Department of Translational Molecular Pathology, University of Texas MD Anderson Cancer Center, Houston, Texas, USA PubMed articles Google scholar articles
Shiaw-Yih Lin Department of Systems Biology, University of Texas MD Anderson Cancer Center, Houston, Texas, USA PubMed articles Google scholar articles
Anirban Maitra Department of Translational Molecular Pathology, University of Texas MD Anderson Cancer Center, Houston, Texas, USA PubMed articles Google scholar articles
Marcelo V Negrao Thoracic/Head and Neck Medical Oncology, University of Texas MD Anderson Cancer Center, Houston, Texas, USA PubMed articles Google scholar articles
Kyle Gregory Mitchell Thoracic and Cardiovascular Surgery, University of Texas MD Anderson Cancer Center, Houston, Texas, USA PubMed articles Google scholar articles
Annikka Weissferdt Department of Pathology, University of Texas MD Anderson Cancer Center, Houston, Texas, USA PubMed articles Google scholar articles
Ara A Vaporciyan Thoracic and Cardiovascular Surgery, University of Texas MD Anderson Cancer Center, Houston, Texas, USA PubMed articles Google scholar articles
Tina Cascone Thoracic/Head and Neck Medical Oncology, University of Texas MD Anderson Cancer Center, Houston, Texas, USA PubMed articles Google scholar articles
Jack A Roth Thoracic and Cardiovascular Surgery, University of Texas MD Anderson Cancer Center, Houston, Texas, USA PubMed articles Google scholar articles
Jianjun Zhang Thoracic/Head and Neck Medical Oncology, University of Texas MD Anderson Cancer Center, Houston, Texas, USA PubMed articles Google scholar articles
Boris Sepesi Thoracic and Cardiovascular Surgery, University of Texas MD Anderson Cancer Center, Houston, Texas, USA PubMed articles Google scholar articles
Don L Gibbons Thoracic/Head and Neck Medical Oncology, University of Texas MD Anderson Cancer Center, Houston, Texas, USA PubMed articles Google scholar articles
John V Heymach Thoracic/Head and Neck Medical Oncology, University of Texas MD Anderson Cancer Center, Houston, Texas, USA PubMed articles Google scholar articles
Cara L Haymaker Department of Translational Molecular Pathology, University of Texas MD Anderson Cancer Center, Houston, Texas, USA PubMed articles Google scholar articles
Daniel J McGrail Department of Systems Biology, University of Texas MD Anderson Cancer Center, Houston, Texas, USA PubMed articles Google scholar articles
Alexandre Reuben Thoracic/Head and Neck Medical Oncology, University of Texas MD Anderson Cancer Center, Houston, Texas, USA PubMed articles Google scholar articles
Chantale Bernatchez Melanoma Medical Oncology, University of Texas MD Anderson Cancer Center, Houston, Texas, USABiologics Development, University of Texas MD Anderson Cancer Center, Houston, Texas, USA PubMed articles Google scholar articles

Citation

Shah P, Forget M, Frank ML, et al

Combined IL-2, agonistic CD3 and 4-1BB stimulation preserve clonotype hierarchy in propagated non-small cell lung cancer tumor-infiltrating lymphocytes

Journal for ImmunoTherapy of Cancer 2022;10:e003082. doi: 10.1136/jitc-2021-003082

Online issue publication

October 18, 2023

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© Author(s) (or their employer(s)) 2022. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ. http://creativecommons.org/licenses/by-nc/4.0/This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See http://creativecommons.org/licenses/by-nc/4.0/.

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