Human CD19-specific switchable CAR T-cells are efficacious as constitutively active CAR T-cells but cause less morbidity in a mouse model of human CD19+ malignancy

Christopher A Pennell; Heather Campbell; Meghan D Storlie; Sara Bolivar-Wagers; Mark J Osborn; Yosef Refaeli; Michael Jensen; Sophie Viaud; Travis S Young; Bruce R Blazar

doi:10.1136/jitc-2022-005934

Article info

Immune cell therapies and immune cell engineering

Human CD19-specific switchable CAR T-cells are efficacious as constitutively active CAR T-cells but cause less morbidity in a mouse model of human CD19⁺ malignancy

Authors

Christopher A Pennell Laboratory Medicine and Pathology, Masonic Cancer Center, University of Minnesota Medical School Twin Cities, Minneapolis, Minnesota, USA PubMed articles Google scholar articles
Heather Campbell Laboratory Medicine and Pathology, University of Minnesota Medical School Twin Cities, Minneapolis, Minnesota, USA PubMed articles Google scholar articles
Meghan D Storlie Laboratory Medicine and Pathology, University of Minnesota Medical School Twin Cities, Minneapolis, Minnesota, USA PubMed articles Google scholar articles
Sara Bolivar-Wagers Department of Pediatrics, Division of Blood & Marrow Transplant & Cellular Therapy, University of Minnesota Medical School Twin Cities, Minneapolis, Minnesota, USA PubMed articles Google scholar articles
Mark J Osborn Department of Pediatrics, Division of Blood & Marrow Transplant & Cellular Therapy, University of Minnesota Medical School Twin Cities, Minneapolis, Minnesota, USA PubMed articles Google scholar articles
Yosef Refaeli Department of Dermatology, University of Colorado Denver School of Medicine, Aurora, Colorado, USA PubMed articles Google scholar articles
Michael Jensen Ben Towne Center for Childhood Cancer Research, Seattle Children's Research Institute, Seattle, Washington, USA PubMed articles Google scholar articles
Sophie Viaud Calibr, The Scripps Research Institute, La Jolla, California, USA PubMed articles Google scholar articles
Travis S Young Calibr, The Scripps Research Institute, La Jolla, California, USA PubMed articles Google scholar articles
Bruce R Blazar Department of Pediatrics, Division of Blood & Marrow Transplant & Cellular Therapy, University of Minnesota Medical School Twin Cities, Minneapolis, Minnesota, USA PubMed articles Google scholar articles

Citation

Pennell CA, Campbell H, Storlie MD, et al

Human CD19-specific switchable CAR T-cells are efficacious as constitutively active CAR T-cells but cause less morbidity in a mouse model of human CD19⁺ malignancy

Journal for ImmunoTherapy of Cancer 2022;10:e005934. doi: 10.1136/jitc-2022-005934

Online issue publication

October 18, 2023

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© Author(s) (or their employer(s)) 2022. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ. http://creativecommons.org/licenses/by-nc/4.0/This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See http://creativecommons.org/licenses/by-nc/4.0/.

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