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  • Both APRIL and antibody-fragment-based CAR T cells for myeloma induce BCMA downmodulation by trogocytosis and internalization

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Immune cell therapies and immune cell engineering
Original research
Both APRIL and antibody-fragment-based CAR T cells for myeloma induce BCMA downmodulation by trogocytosis and internalization

Authors

  • Nicolas Camviel Department of Oncology UNIL CHUV, Lausanne University Hospital (CHUV) and University of Lausanne (UNIL), Lausanne, SwitzerlandLudwig Institute for Cancer Research Lausanne Branch, Lausanne, Switzerland PubMed articlesGoogle scholar articles
  • Benita Wolf Department of Oncology UNIL CHUV, Lausanne University Hospital (CHUV) and University of Lausanne (UNIL), Lausanne, SwitzerlandLudwig Institute for Cancer Research Lausanne Branch, Lausanne, Switzerland PubMed articlesGoogle scholar articles
  • Giancarlo Croce Department of Oncology UNIL CHUV, Lausanne University Hospital (CHUV) and University of Lausanne (UNIL), Lausanne, SwitzerlandLudwig Institute for Cancer Research Lausanne Branch, Lausanne, SwitzerlandSwiss Institute of Bioinformatics (SIB), Lausanne, Switzerland PubMed articlesGoogle scholar articles
  • David Gfeller Department of Oncology UNIL CHUV, Lausanne University Hospital (CHUV) and University of Lausanne (UNIL), Lausanne, SwitzerlandLudwig Institute for Cancer Research Lausanne Branch, Lausanne, SwitzerlandSwiss Institute of Bioinformatics (SIB), Lausanne, Switzerland PubMed articlesGoogle scholar articles
  • Vincent Zoete Department of Oncology UNIL CHUV, Lausanne University Hospital (CHUV) and University of Lausanne (UNIL), Lausanne, SwitzerlandLudwig Institute for Cancer Research Lausanne Branch, Lausanne, SwitzerlandSwiss Institute of Bioinformatics (SIB), Lausanne, Switzerland PubMed articlesGoogle scholar articles
  • Caroline Arber Department of Oncology UNIL CHUV, Lausanne University Hospital (CHUV) and University of Lausanne (UNIL), Lausanne, SwitzerlandLudwig Institute for Cancer Research Lausanne Branch, Lausanne, Switzerland PubMed articlesGoogle scholar articles

Citation

Camviel N, Wolf B, Croce G, et al
Both APRIL and antibody-fragment-based CAR T cells for myeloma induce BCMA downmodulation by trogocytosis and internalization
Journal for ImmunoTherapy of Cancer 2022;10:e005091. doi: 10.1136/jitc-2022-005091
Online issue publication 
October 18, 2023

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© Author(s) (or their employer(s)) 2022. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ. http://creativecommons.org/licenses/by-nc/4.0/This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See http://creativecommons.org/licenses/by-nc/4.0/.