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  • TIM-3 blockade enhances IL-12-dependent antitumor immunity by promoting CD8+ T cell and XCR1+ dendritic cell spatial co-localization

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Basic tumor immunology
Original research
TIM-3 blockade enhances IL-12-dependent antitumor immunity by promoting CD8+ T cell and XCR1+ dendritic cell spatial co-localization

Authors

  • Alycia Gardner Department of Immunology, H Lee Moffitt Cancer Center and Research Institute, Tampa, Florida, USACancer Biology PhD Program, University of South Florida, Tampa, Florida, USA PubMed articlesGoogle scholar articles
  • Álvaro de Mingo Pulido Department of Immunology, H Lee Moffitt Cancer Center and Research Institute, Tampa, Florida, USA PubMed articlesGoogle scholar articles
  • Kay Hänggi Department of Immunology, H Lee Moffitt Cancer Center and Research Institute, Tampa, Florida, USA PubMed articlesGoogle scholar articles
  • Sarah Bazargan Department of Immunology, H Lee Moffitt Cancer Center and Research Institute, Tampa, Florida, USACancer Biology PhD Program, University of South Florida, Tampa, Florida, USA PubMed articlesGoogle scholar articles
  • Alexis Onimus Department of Immunology, H Lee Moffitt Cancer Center and Research Institute, Tampa, Florida, USAMolecular Medicine PhD Program, University of South Florida, Tampa, Florida, USA PubMed articlesGoogle scholar articles
  • Agnieszka Kasprzak Analytic Microscopy, H Lee Moffitt Cancer Center and Research Institute, Tampa, Florida, USA PubMed articlesGoogle scholar articles
  • Jose R Conejo-Garcia Department of Immunology, H Lee Moffitt Cancer Center and Research Institute, Tampa, Florida, USA PubMed articlesGoogle scholar articles
  • Katarzyna A Rejniak Department of Integrated Mathematical Oncology, H Lee Moffitt Cancer Center and Research Institute, Tampa, Florida, USA PubMed articlesGoogle scholar articles
  • Brian Ruffell Department of Immunology, H Lee Moffitt Cancer Center and Research Institute, Tampa, Florida, USADepartment of Breast Oncology, H Lee Moffitt Cancer Center and Research Institute, Tampa, Florida, USA PubMed articlesGoogle scholar articles

Citation

Gardner A, de Mingo Pulido Á, Hänggi K, et al
TIM-3 blockade enhances IL-12-dependent antitumor immunity by promoting CD8+ T cell and XCR1+ dendritic cell spatial co-localization
Journal for ImmunoTherapy of Cancer 2022;10:e003571. doi: 10.1136/jitc-2021-003571
Online issue publication 
October 18, 2023

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© Author(s) (or their employer(s)) 2022. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ. http://creativecommons.org/licenses/by-nc/4.0/This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See http://creativecommons.org/licenses/by-nc/4.0/.