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717 AMG 160, a prostate-specific membrane antigen (PSMA)-targeted BiTE^® immuno-oncology therapy, is active in models of advanced prostate cancer that are resistant to radioligand therapy
Katharina Lueckerath, Julie Bailis, Kyle Current, Mark Salvati, Caius Radu, Johannes Czernin

Journal for ImmunoTherapy of Cancer Nov 2020, 8 (Suppl 3) A429-A430; DOI: 10.1136/jitc-2020-SITC2020.0717
716 Cell-based virotherapy for targeting cancers
Duong Nguyen, Alberto Gomez, Forrest Neuharth, Ashley Alamillo, Thomas Herrmann, Barbara Härtl, Laura Schneider, Ivelina Minev, Boris Minev, Dobrin Draganov, Antonio Santidrian

Journal for ImmunoTherapy of Cancer Nov 2020, 8 (Suppl 3) A429; DOI: 10.1136/jitc-2020-SITC2020.0716
69 Automated TRB locus haplotype analysis by long-amplicon TCRB chain sequencing for potential immune-related adverse events biomarker research
Jennifer Burke, Frances Chen, Jiajie Huang, Geoffrey Lowman, Timothy Looney, Marina Sedova

Journal for ImmunoTherapy of Cancer Nov 2020, 8 (Suppl 3) A43; DOI: 10.1136/jitc-2020-SITC2020.0069
721 AT1412, a patient-derived CD9 antibody in preclinical development promoting tumor immune infiltration and inducing tumor rejection
Remko Schotte, Julien Villaudy, Martijn Kedde, Wouter Pos, Daniel Go, Christien Fatmawati, Gemma Moiset, Etsuko Yasuda, Madalina Cercel, Esmay Frankin, Susan van Hal, Pauline van Helden, Els Verdegaal, Sjoerd van der Burg, Hergen Spits, Hans van Eenennaam

Journal for ImmunoTherapy of Cancer Nov 2020, 8 (Suppl 3) A431-A432; DOI: 10.1136/jitc-2020-SITC2020.0721
720 Targeting MARCO and IL-37R on anti-inflammatory macrophages in lung cancer blocks regulatory T cells and shift balance to support cytotoxic lymphocyte function
Linnéa La Fleur, Johan Botling, Fei He, Catarina Pelicano, Giorgia Palano, Artur Mezheyeuski, Patrick Micke, Jeffrey Ravetch, Mikael Karlsson, Dhifaf Sarhan

Journal for ImmunoTherapy of Cancer Nov 2020, 8 (Suppl 3) A431; DOI: 10.1136/jitc-2020-SITC2020.0720
724 STAT3 inhibition in acute myeloid leukemia cells allows for TLR9-driven differentiation to immunogenic monocytic cells and induction of T-cell mediated immune responses
Yu-Lin Su, Marcin Kortylewski, Priyanka Duttagupta

Journal for ImmunoTherapy of Cancer Nov 2020, 8 (Suppl 3) A433-A434; DOI: 10.1136/jitc-2020-SITC2020.0724
726 SRF114 is a fully human, CCR8 selective IgG1 antibody that induces destruction of tumor Tregs through ADCC
Andrew Lake, Michael Warren, Sonia Das, Christopher Wells, Maria Scrivens, Ernest Smith, Vito Palombella, Bijan Etemad-Gilbertson, Pamela Holland, Austin Dulak

Journal for ImmunoTherapy of Cancer Nov 2020, 8 (Suppl 3) A434-A435; DOI: 10.1136/jitc-2020-SITC2020.0726
727 Increased serum levels of EBI3 are associated with poor outcome in hepatocellular carcinoma patients and SRF388, a first-in-class IL-27 blocking antibody, inhibits the growth of murine liver tumors
Matthew Rausch, Devapregasan Moodley, Marisa Peluso, Secil Koseoglu, Jing Hua, Gege Tan, Ricard Masia, Benjamin Lee, Isabelle Cousineau, Simon Turcotte, John Stagg, Vito Palombella, Pamela Holland, Jonathan Hill

Journal for ImmunoTherapy of Cancer Nov 2020, 8 (Suppl 3) A435; DOI: 10.1136/jitc-2020-SITC2020.0727
731 Costs of care for first-line (1L) treatment of advanced non-small cell lung cancer (aNSCLC): a real-world claims analysis
Jonathan Kish, Dhruv Chopra, Djibril Liassou, Solomon Lubinga, John Hartman, Bruce Feinberg

Journal for ImmunoTherapy of Cancer Nov 2020, 8 (Suppl 3) A437-A438; DOI: 10.1136/jitc-2020-SITC2020.0731
733 Integrative molecular profiling of high-grade primary prostate cancer identifies patients with a biomarker profile that favors the combination of standard of care (SOC) therapy with immunotherapy
Evisa Gjini, Jimena Trillo-Tinoco, Andrew Browne, Ryan Powles, Tai Wang, Christine Tauras, Ana Lako, Ruben Ferrer-Luna, Zoe Bleicher, Timothy Consedine, Chensheng Zhou, Evan Kelemen, Anne Lewin, Catherine King, Sumit Bhattacharya, Harris Bell-Temin, Ashok Dongre, David Nelson, Christos Hatzis, Kenzie Macisaac, Fadi Towfic, Benjamin Chen, Michaela Bowden

Journal for ImmunoTherapy of Cancer Nov 2020, 8 (Suppl 3) A438-A439; DOI: 10.1136/jitc-2020-SITC2020.0733

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