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694 NC410 is a novel immunomedicine for the treatment of solid tumors
Linjie Tian, M Ines Pascoal Ramos, Emma de Ruiter, Ana Paucarmayta, Eline Elshof, Stefan Willems, Chang Song, Zachary Cusumano, Jason Bosiacki, Linda Liu, Solomon Langermann, Linde Meyaard, Dallas Flies

Journal for ImmunoTherapy of Cancer Nov 2020, 8 (Suppl 3) A417-A418; DOI: 10.1136/jitc-2020-SITC2020.0694
699 A differentiated anti-OX40 agonist BGB-A445 does not block OX40-OX40L interaction and reveals remarkable anti-tumor efficacy in preclinical models
Ye Liu, Beibei Jiang, Tong Zhang, Zuobai Wang, Yingcai Feng, Haiying Li, Wenfeng Gong, Xing Wang, Yajuan Gao, Xiaosui Zhou, Bo Zhang, Yuan Hong, Jing Wang, Zilin Wang, Hongjia Hou, Hanzi Sun, Xiaomin Song, Kang Li, Xuesong Liu

Journal for ImmunoTherapy of Cancer Nov 2020, 8 (Suppl 3) A420; DOI: 10.1136/jitc-2020-SITC2020.0699
700 EphA2/CD137 Bicycle tumor-targeted immune cell agonists (TICAs^TM) induce tumor regressions, immunogenic memory, and reprogramming of the tumor immune microenvironment
Kristen Hurov, Johanna lahdenranta, Gemma Mudd, Punit Upadhyaya, Elizabeth Repash, Jun Ma, Julia Kristensson, Marianna Kleyman, Jessica Kublin, Liuhong Chen, Eric Haines, Sailaja Battula, Kevin McDonnell, Philip Brandish, Nicholas Keen

Journal for ImmunoTherapy of Cancer Nov 2020, 8 (Suppl 3) A420-A421; DOI: 10.1136/jitc-2020-SITC2020.0700
701 Nanoparticulate monobenzone (MBEH) as a potential drug candidate for melanoma
Dinesh Jaishankar, Steven Henning, Anqi Zhang, Basar Bilgicer, SonBinh Nhuyen, I Caroline Le Poole

Journal for ImmunoTherapy of Cancer Nov 2020, 8 (Suppl 3) A421; DOI: 10.1136/jitc-2020-SITC2020.0701
702 Dual blockade of the PD-1 checkpoint pathway and the adenosinergic negative feedback signaling pathway with a PD-1/CD73 bispecific antibody for cancer immune therapy
Tingting Zhong, Zhaoliang Huang, Xinghua Pang, Na Chen, Xiaoping Jin, Yu Xia, Zhongmin Maxwell Wang, Baiyong Li, Yu Xia

Journal for ImmunoTherapy of Cancer Nov 2020, 8 (Suppl 3) A422; DOI: 10.1136/jitc-2020-SITC2020.0702
705 Anti-tumor activity of CB-668, a potent, selective and orally bioavailable small-molecule inhibitor of the immuno-suppressive enzyme Interleukin 4 (IL-4)-Induced Gene 1 (IL4I1)
Andrew MacKinnon, Deepthi Bhupathi, Jason Chen, Tony Huang, Weiqun Li, Yong Ma, Natalija Sotirovska, Susanne Steggerda, Winter Zhang, Francesco Parlati

Journal for ImmunoTherapy of Cancer Nov 2020, 8 (Suppl 3) A423-A424; DOI: 10.1136/jitc-2020-SITC2020.0705
709 Exosome surface display of IL-12 results in tumor-retained pharmacology with superior potency and limited systemic exposure
Nuruddeen Lewis, Chang Ling Sia, Katherine Kirwin, Sonya Haupt, Gauri Mahimkar, Tong Zi, Ke Xu, Kevin Dooley, Su Chul Jang, Bryan Choi, Andrew Grube, Christine McCoy, Jorge Sanchez-Salazar, Michael Doherty, Scott Estes, Kyriakos Economides, Douglas Williams, Sriram Sathyanaryanan

Journal for ImmunoTherapy of Cancer Nov 2020, 8 (Suppl 3) A425-A426; DOI: 10.1136/jitc-2020-SITC2020.0709
710 Development of IL-33 as a novel immunotherapy of cancer
Joshua Zhong, Runzi Sun, Binfeng Lu

Journal for ImmunoTherapy of Cancer Nov 2020, 8 (Suppl 3) A426; DOI: 10.1136/jitc-2020-SITC2020.0710
711 HBM1022, a novel anti-CCR8 antibody depletes tumor-infiltrating regulatory T cells via enhanced ADCC activity, mediates potent anti-tumor activity with Keytruda
Shuang Lu, Shaoping Hu, Xin Gan, Yongqiang Wang, Chuchu Zhao, Yi Ding, Jinqiu He, Qing Du, Xiaocheng Lv, Beibei Qin, Yun He, Lei Niu, Yuntao Wu, Fei Chen, Yuandong Wang, Yunxing Yang, Yang Cao, Musheng Bao, Jason Noon, Wenhao Yu, Juan Liu, Joe Zhao, Yiping Rong, Shuang Lu

Journal for ImmunoTherapy of Cancer Nov 2020, 8 (Suppl 3) A426; DOI: 10.1136/jitc-2020-SITC2020.0711
713 Antibody-based approach of MT1-MMP metalloprotease inhibition results in decreased invasive properties of pancreatic cancer cells
Nikita Mitkin, Alisa Gorbacheva, Alina Ustiugova, Aksinya Uvarova, Kirill Korneev, Vsevolod Pavshintsev, Nikita Mitkin

Journal for ImmunoTherapy of Cancer Nov 2020, 8 (Suppl 3) A427-A428; DOI: 10.1136/jitc-2020-SITC2020.0713

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