Open access

49 In situ phenotypic analysis of T cells in the tumor microenvironment of a pre-clinical model of non-small cell lung cancer (NSCLC) by tissue sectioning and whole-mount immunofluorescence imaging
Elen Torres, Stefani Spranger

Journal for ImmunoTherapy of Cancer Nov 2020, 8 (Suppl 3) A30-A31; DOI: 10.1136/jitc-2020-SITC2020.0049
486 iReceptor plus: a data integration platform to share, compare and analyze adaptive immune receptor repertoire (AIRR-seq) data from antibody/B- and T-cell repertoires
Felix Breden

Journal for ImmunoTherapy of Cancer Nov 2020, 8 (Suppl 3) A300-A301; DOI: 10.1136/jitc-2020-SITC2020.0486
490 An immuno-oncology census: assessment of clinician knowledge and educational needs in 2020
Janelle Schrag, Fitzgerald Draper, Monique Dawkins, Lorna Lucas, Leigh Boehmer

Journal for ImmunoTherapy of Cancer Nov 2020, 8 (Suppl 3) A302-A303; DOI: 10.1136/jitc-2020-SITC2020.0490
495 Basal cell carcinoma demonstrates a T-cell exclusion immune phenotype in contrast to other anti-PD-1 therapy responsive cutaneous malignancies
Geoffrey Gibney, Joanne Xiu, Gino In, Steven O’Day, Jose Lutzky, Joseph Drabick, Ari VanderWalde, Kelsey Poorman, W Korn, Michael Atkins

Journal for ImmunoTherapy of Cancer Nov 2020, 8 (Suppl 3) A305; DOI: 10.1136/jitc-2020-SITC2020.0495
498 Downregulation of CD5 in CD8+ T tumour-infiltrating lymphocytes associates with increased level of activation and exhaustion
Faizah Alotaibi, Mark Vincent, Weiping Min, James Koropatnick

Journal for ImmunoTherapy of Cancer Nov 2020, 8 (Suppl 3) A306-A307; DOI: 10.1136/jitc-2020-SITC2020.0498
497 Longitudinal immune profiling reveals unique myeloid and T cell phenotypes associated with spontaneous immunoediting in a novel prostate tumor model
Casey Ager, Aleksander Obradovic, Juan Arriaga, Matthew Chaimowitz, Cory Abate-Shen, Andrea Califano, Charles Drake

Journal for ImmunoTherapy of Cancer Nov 2020, 8 (Suppl 3) A306; DOI: 10.1136/jitc-2020-SITC2020.0497
499 AT1636, a colon cancer survivor-derived antibody recognizes a previously unidentified truncated, O-mannosylated 70kDa variant of E-cadherin
Tim Beaumont, Martijn Kedde, Sabrina Merat, Mark Kwakkenbos, Lina Bartels, Dorien van der Berg, Koen Wagner, Arjen Bakker, Kelly Maijoor, Martino Bohne, Camille Bru, Veronika Kattler, Yvonne Claassen, Gemma Moiset, Hans Van Eenennaam, Victorine Roos, Frank Kallenberg, Jan Medema, Paul Hensbergen, Pauline van Helden, Evelien Dekker, Hergen Spits

Journal for ImmunoTherapy of Cancer Nov 2020, 8 (Suppl 3) A307; DOI: 10.1136/jitc-2020-SITC2020.0499
501 VISTA regulates the differentiation and suppressive function of myeloid-derived suppressor cells
Juan Dong, Cassandra Gilmore, Hieu Ta, Keman Zhang, Sarah Stone, Li Wang

Journal for ImmunoTherapy of Cancer Nov 2020, 8 (Suppl 3) A308; DOI: 10.1136/jitc-2020-SITC2020.0501
502 The co-expression of two immune complex molecules, VISTA and TIGIT, define a dysfunctional cytotoxic T cell subset
Cassandra Gilmour, Li Wang, Juan Dong, Hieu Ta

Journal for ImmunoTherapy of Cancer Nov 2020, 8 (Suppl 3) A309; DOI: 10.1136/jitc-2020-SITC2020.0502
508 Different neoantigen expression patterns impact the strength of anti-tumor immune responses
Kim Nguyen, Stefani Spranger, Christopher Copeland

Journal for ImmunoTherapy of Cancer Nov 2020, 8 (Suppl 3) A313; DOI: 10.1136/jitc-2020-SITC2020.0508

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