Open access

456 Impact of angiotensin II pathway inhibition on tumor response to anti PD(L)1 based therapy
Julius Strauss, Ravi Madan, Marijo Bilusic, Fatima Karzai, Scot Niglio, Jason Redman, Houssein Abdul Sater, Charalampos Floudas, Jung-Min Lee, Andrea Apolo, Seth Steinberg, Jeffrey Schlom, James Gulley

Journal for ImmunoTherapy of Cancer Nov 2020, 8 (Suppl 3) A276-A277; DOI: 10.1136/jitc-2020-SITC2020.0456
454 Oncolytic parainfluenza virus 5 vector enhances natural killer cell killing of lung tumor cells in 2D and 3D spheroid cultures
Namita Varudkar, Jeremiah Oyer, Alicja Copik, Griffith Parks

Journal for ImmunoTherapy of Cancer Nov 2020, 8 (Suppl 3) A276; DOI: 10.1136/jitc-2020-SITC2020.0454
457 Intratumoral interleukin-12 administered after cryoablation does not improve survival in multiple bilateral murine models
Maura Vrabel, Jake Schulman, David Zaharoff

Journal for ImmunoTherapy of Cancer Nov 2020, 8 (Suppl 3) A277-A278; DOI: 10.1136/jitc-2020-SITC2020.0457
458 Antitumor mechanisms of local radiation and combination immunotherapy in an immunologically cold model of neuroblastoma
Taylor Aiken, Julie Voeller, Amy Erbe, Alexander Rakhmilevich, Paul Sondel

Journal for ImmunoTherapy of Cancer Nov 2020, 8 (Suppl 3) A278-A279; DOI: 10.1136/jitc-2020-SITC2020.0458
460 The immuno-metabolic enzyme FASN prevents anti-tumor immune responses in irradiated glioblastoma
Mara De Martino, Camille Daviaud, Claire Vanpouille-Box

Journal for ImmunoTherapy of Cancer Nov 2020, 8 (Suppl 3) A279-A280; DOI: 10.1136/jitc-2020-SITC2020.0460
459 NK cells activation and recruitment to irradiated tumors is increased in the presence of IL-15
Maud Charpentier, Karsten Pilones, Elena Garcia-Martinez, Sandra Demaria

Journal for ImmunoTherapy of Cancer Nov 2020, 8 (Suppl 3) A279; DOI: 10.1136/jitc-2020-SITC2020.0459
461 Improving specific targeting of tumors through bispecific SNIPER antibodies
Amy Erbe, Daniel Gerhardt, Reinier Hernandez, Bonnie Hammer, Mildred Felder, Mark Bercher, Jennifer Dennin, Christopher Massey, Sabrina VandenHeuvel, Arika Feils, Mackenzie Heck, Jonathan Engle, Todd Barnhart, Jacquelyn Hank, Bryan Glaser, Roland Green, Paul Sondel

Journal for ImmunoTherapy of Cancer Nov 2020, 8 (Suppl 3) A280; DOI: 10.1136/jitc-2020-SITC2020.0461
462 Single agent immunotherapy response in patients with head and neck squamous cell carcinoma with prior history of radiation therapy
Moises Harari-Turquie, Shashank Cingam, David Lee, Gregory Gan, Emrullah Yilmaz, Emrullah Yilmaz

Journal for ImmunoTherapy of Cancer Nov 2020, 8 (Suppl 3) A280-A281; DOI: 10.1136/jitc-2020-SITC2020.0462
463 Metastatic gastric cancer patient benefiting from combined radio-immunotherapy treatment displayed sustained anti-NY-ESO-1 specific T cells and expressed important immuno-modulatory markers
Maysaloun Merhi, Afsheen Raza, Varghese Inchakalody, Siveen Kodappully, Deepak Choubey, Fairooz Sahir, Sarra Mestiri, Shereena Hydrose, Niloofar Allahverdi, Munir Jalis, Allan Relecom, Lobna Al-Zaidan, Mohamed Sir Elkhatim Hamid, Mai Mostafa, Abdul Rehman Zar Gul, Shahab Uddin, Mohammed Ussama Al Homsi, Maysaloun Merhi, Said Dermine

Journal for ImmunoTherapy of Cancer Nov 2020, 8 (Suppl 3) A281-A282; DOI: 10.1136/jitc-2020-SITC2020.0463
464 Clonal replacement of tumor-infiltrating CD8+ T cells by induction and activation of tumor-residing Batf3-dependent dendritic cells
Takaaki Oba, Mark Long, Tibor Keler, Henry Marsh, Hans Minderman, Scott Abrams, Song Liu, Fumito Ito

Journal for ImmunoTherapy of Cancer Nov 2020, 8 (Suppl 3) A282-A283; DOI: 10.1136/jitc-2020-SITC2020.0464

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