Open access

478 A novel antagonist monoclonal antibody against human adenosine receptor 2a (A2aR) for cancer immunotherapies
Changyun Hu, Yanyan Wang, Xiqian Lan, Jiandong Zhang, Xinyan Zhao

Journal for ImmunoTherapy of Cancer Nov 2023, 11 (Suppl 1) A537; DOI: 10.1136/jitc-2023-SITC2023.0478
479 Fc-competent fully human anti-TIGIT blocking monoclonal antibodies demonstrated potent anti-tumor efficacy in preclinical models
Weiqiu Lan, Baihong Liu, Yang Chen, Xin Zhang, Jing Zhang, W Frank An, Chaoshe Guo, Yi Yang

Journal for ImmunoTherapy of Cancer Nov 2023, 11 (Suppl 1) A538; DOI: 10.1136/jitc-2023-SITC2023.0479
480 Translational PK/RO model of tetravalent bispecific antibody CTX8371: receptor occupancy estimation, PD1 loss and bispecific binding-related avidity increase in low doses
Veronika Musatovac, Oleg Demin, Oleg Demin

Journal for ImmunoTherapy of Cancer Nov 2023, 11 (Suppl 1) A539; DOI: 10.1136/jitc-2023-SITC2023.0480
481 A CXCR4 partial agonist TFF2-MSA sensitized advanced gastric cancer to PD-1 blockade by systematically reducing PMN-MDSC accumulation, immunosuppression, and generation in bone marrow
Jin Qian, Sandra Ryeom, Bruce L Daugherty, Seth Lederman, Timothy C Wang

Journal for ImmunoTherapy of Cancer Nov 2023, 11 (Suppl 1) A540; DOI: 10.1136/jitc-2023-SITC2023.0481
483 Extra-nodal memory T cell populations confer durable anticancer immunity following successful primary tumor responses to ICI
Shiqi Tang, Riyam Al Msari, J Silvio Gutkind, Robert Saddawi-Konefka

Journal for ImmunoTherapy of Cancer Nov 2023, 11 (Suppl 1) A542; DOI: 10.1136/jitc-2023-SITC2023.0483
484 Abstract withdrawn
Journal for ImmunoTherapy of Cancer Nov 2023, 11 (Suppl 1) A543; DOI: 10.1136/jitc-2023-SITC2023.0484
485 TIGIT/PVRIG humanized mice-an idea model for studying anti-PVRIG antibodies
Huiyi Wang, Xu Su, Jingjing Zhang, Mingkun Zhang, Shuai Li, Santi Chen, Zhiying Li, Mark Moore, Jing Zhao, Xiang Gao, Cunxiang Ju

Journal for ImmunoTherapy of Cancer Nov 2023, 11 (Suppl 1) A544; DOI: 10.1136/jitc-2023-SITC2023.0485
486 Combined PD-L1/TGFβ blockade allows expansion and differentiation of stem cell-like CD8 T cells in immune excluded tumors
Katherine Williams, Alessandra Castiglioni, Yagai Yang, Alvin Gogineni, Jillian Astarita, Justin Elstrott, Zora Modrusan, Ira Mellman, Shannon Turley, Soren Muller

Journal for ImmunoTherapy of Cancer Nov 2023, 11 (Suppl 1) A545; DOI: 10.1136/jitc-2023-SITC2023.0486
487 Abstract withdrawn
Journal for ImmunoTherapy of Cancer Nov 2023, 11 (Suppl 1) A546; DOI: 10.1136/jitc-2023-SITC2023.0487
488 Abstract withdrawn
Journal for ImmunoTherapy of Cancer Nov 2023, 11 (Suppl 1) A547-A550; DOI: 10.1136/jitc-2023-SITC2023.0488

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