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438 In vivo Engineered CAR-T cells for oncology using a surface-engineered lentivirus platform: nonclinical safety and biodistribution
Alissa Brandes, Soo Min Koo, Don Parilla, Susana Hernandez, Christopher Nicolai, Alyssa Sheih, Anna Ting, Kathryn Michels, Tim Gervascio, Nanda Coelho, Anai Perez, Jessica Freeman, Mason Muhonen, Sarah Gould, Alessandra M Sullivan, Jeff Teoh, Rich Getto, Byoung Ryu, Andrew Scharenberg, Ryan Larson

Journal for ImmunoTherapy of Cancer Nov 2023, 11 (Suppl 1) A487; DOI: 10.1136/jitc-2023-SITC2023.0438
439 Cardiovascular safety of chimeric antigen receptor (CAR) T cell therapy
Felix Korell, Lukas Entenmann, Anita Schmitt, Carsten Müller-Tidow, Norbert Frey, Peter Dreger, Michael Schmitt, Lorenz Lehmann

Journal for ImmunoTherapy of Cancer Nov 2023, 11 (Suppl 1) A488; DOI: 10.1136/jitc-2023-SITC2023.0439
440 Preclinical safety assessment for specificity of biotherapeutics using the membrane proteome array
Tabb Sullivan, Carmen Navia, Rona Wilf, Rachel Fong, Benjamin Doranz

Journal for ImmunoTherapy of Cancer Nov 2023, 11 (Suppl 1) A489; DOI: 10.1136/jitc-2023-SITC2023.0440
441 Development of a repeated challenge potency assay for evaluation of immune cell-mediated cytotoxicity in vitro
Denise Sullivan, Sayem H Bhuiyan, George Huang, Danielle Califano, Stacie Chvatal, Daniel Millard

Journal for ImmunoTherapy of Cancer Nov 2023, 11 (Suppl 1) A490; DOI: 10.1136/jitc-2023-SITC2023.0441
442 CAIX targeted CAR-T cells exhibited antitumor efficacy on renal cell carcinoma (RCC) patient derived organotypic tumor spheroids (PDOTS)
Yufei Wang, Alicia Buck, Brandon Piel, Luann Zerefa, Andras-Gabor Miklosi, Kun Huang, Gabriella Kastrunes, Marion Grimaud, Atef Fayed, Miriam Ficial, Sabina Signoretti, Tran Thai, Elena Ivanova, Cloud Paweletz, Ming-Ru Wu, Jon Wee, Toni K Choueiri, Gordon Freeman, David Barbie, Wayne Marasco

Journal for ImmunoTherapy of Cancer Nov 2023, 11 (Suppl 1) A491; DOI: 10.1136/jitc-2023-SITC2023.0442
443 Pembrolizumab for BCG refractory non-muscle invasive bladder cancer yields poor recurrence-free survival and high toxicity in patients
Borivoj Golijanin, Vikas Bhatt, Ali Amin, Galina Lagos, Andre De Souza, Anthony E Mega, Dragan Golijanin

Journal for ImmunoTherapy of Cancer Nov 2023, 11 (Suppl 1) A492; DOI: 10.1136/jitc-2023-SITC2023.0443
444 Unveiling immune-related adverse events (irAEs) and symptom burden in melanoma patients on adjuvant immune checkpoint inhibitors (ICIs)
Noha Abdel-Wahab, Bilal Anouti, Reham Abdel-Wahab, Zaida Gonzales, Christine A Spillson, George P Baum, Salah-Eddine Bentebibel, Joanna-Grace M Manzano, Jennifer McQuade, Isabella Glitza, Rodabe Amaria, Sapna Patel, Michael K Wong, Hussain Tawbi, Michael A Davies, Suhendan Ekmekcioglu, David Tweardy, Padmanee Sharma, Sanjay Shete, Susan Peterson, Cassian Yee, Maria E Suarez-Almazor, Adi Diab

Journal for ImmunoTherapy of Cancer Nov 2023, 11 (Suppl 1) A493; DOI: 10.1136/jitc-2023-SITC2023.0444
445 The relationship between immune-related adverse events (irAEs) and ctDNA status: exploratory analysis from IMvigor010
Corey Carter, Katrin Madjar, Bogdana I Balas, Laurent Essioux, Viraj Degaonkar, Sanjeev Mariathasan, G Scott Chandler, Rajat Mohindra, Thomas Powles

Journal for ImmunoTherapy of Cancer Nov 2023, 11 (Suppl 1) A494-A495; DOI: 10.1136/jitc-2023-SITC2023.0445
446 The administration of JAK and TYK2 inhibitor successfully ameliorated the severity of T cell transfer-induced colitis in mice
Chunhui He, Yanping Yuan, Juan Wang, Dongye Jia, Xiangnan Qiang, Ruiqing Yan, Nan Xie

Journal for ImmunoTherapy of Cancer Nov 2023, 11 (Suppl 1) A496; DOI: 10.1136/jitc-2023-SITC2023.0446
447 Evaluation of efficacy and toxicity of human CD40 agonistic antibodies in C57BL/6-hCD40/hFcγRIIB HuGEMM^TM
Demi X Liu, Kaixia Lian, Xuefei Yan, Rong Wang, Jie Lin, Xinhe Feng, Xiaolong Tu, Chengcheng Wang, Lei Zheng, Xiaoxi Xu, Annie An, Ludovic Bourre, Jessie Wang

Journal for ImmunoTherapy of Cancer Nov 2023, 11 (Suppl 1) A497; DOI: 10.1136/jitc-2023-SITC2023.0447

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