Basic Tumor Immunology

Robust IL-2-dependent antitumor immunotherapy requires targeting the high-affinity IL-2R on tumor-specific CD8⁺ T cells
Kathryn M LaPorte, Rosmely Hernandez, Alicia Santos Savio, Thomas R Malek

Journal for ImmunoTherapy of Cancer Jun 2023, 11 (6) e006611; DOI: 10.1136/jitc-2022-006611
Anti-HVEM mAb therapy improves antitumoral immunity both in vitro and in vivo, in a novel transgenic mouse model expressing human HVEM and BTLA molecules challenged with HVEM expressing tumors
Clémence Demerlé, Laurent Gorvel, Marielle Mello, Sonia Pastor, Clara Degos, Ana Zarubica, Fabien Angelis, Frédéric Fiore, Jacques A Nunes, Bernard Malissen, Laurent Greillier, Geoffrey Guittard, Hervé Luche, Fabrice Barlesi, Daniel Olive

Journal for ImmunoTherapy of Cancer May 2023, 11 (5) e006348; DOI: 10.1136/jitc-2022-006348
Dual TLR9 and PD-L1 targeting unleashes dendritic cells to induce durable antitumor immunity
Laura Fernandez-Rodriguez, Chiara Cianciaruso, Ruben Bill, Marcel P Trefny, Richard Klar, Nicole Kirchhammer, Mélanie Buchi, Julia Festag, Sven Michel, Rainer H Kohler, Elham Jones, Andre Maaske, Johannes vom Berg, Sebastian Kobold, Abhishek S Kashyap, Frank Jaschinski, Karen O Dixon, Mikael J Pittet, Alfred Zippelius

Journal for ImmunoTherapy of Cancer May 2023, 11 (5) e006714; DOI: 10.1136/jitc-2023-006714
Dual receptor T cells mediate effective antitumor immune responses via increased recognition of tumor antigens
Hyun J Jang, Christine Caron, Calvin K Lee, Lu Wang, Burhan Jama, Jack D Bui, Gerald P Morris

Journal for ImmunoTherapy of Cancer May 2023, 11 (5) e006472; DOI: 10.1136/jitc-2022-006472
AR-A014418 regulates intronic polyadenylation and transcription of PD-L1 through inhibiting CDK12 and CDK13 in tumor cells
Ganggang Zhang, Bin Lan, Xin Zhang, Mengyao Lin, Yi Liu, Junsong Chen, Fang Guo

Journal for ImmunoTherapy of Cancer May 2023, 11 (5) e006483; DOI: 10.1136/jitc-2022-006483
Maximizing cancer therapy via complementary mechanisms of immune activation: PD-1 blockade, neoantigen vaccination, and Tregs depletion
Anna Morena D'Alise, Guido Leoni, Maria De Lucia, Francesca Langone, Linda Nocchi, Fabio Giovanni Tucci, Elisa Micarelli, Gabriella Cotugno, Fulvia Troise, Irene Garzia, Rosa Vitale, Veronica Bignone, Elena Di Matteo, Rosa Bartolomeo, Deborah H Charych, Armin Lahm, Jonathan Zalevsky, Alfredo Nicosia, Elisa Scarselli

Journal for ImmunoTherapy of Cancer Nov 2021, 9 (11) e003480; DOI: 10.1136/jitc-2021-003480
BT7480, a novel fully synthetic Bicycle tumor-targeted immune cell agonist™ (Bicycle TICA™) induces tumor localized CD137 agonism
Kristen Hurov, Johanna Lahdenranta, Punit Upadhyaya, Eric Haines, Heather Cohen, Elizabeth Repash, Drasti Kanakia, Jun Ma, Julia Kristensson, Fanglei You, Carly Campbell, David Witty, Mike Kelly, Stephen Blakemore, Phil Jeffrey, Kevin McDonnell, Philip Brandish, Nicholas Keen

Journal for ImmunoTherapy of Cancer Nov 2021, 9 (11) e002883; DOI: 10.1136/jitc-2021-002883
DPP inhibition alters the CXCR3 axis and enhances NK and CD8+ T cell infiltration to improve anti-PD1 efficacy in murine models of pancreatic ductal adenocarcinoma
Allison A Fitzgerald, Shangzi Wang, Veena Agarwal, Emily F Marcisak, Annie Zuo, Sandra A Jablonski, Melanie Loth, Elana J Fertig, John MacDougall, Eugene Zhukovsky, Shubhendu Trivedi, Dimple Bhatia, Vince O'Neill, Louis M Weiner

Journal for ImmunoTherapy of Cancer Nov 2021, 9 (11) e002837; DOI: 10.1136/jitc-2021-002837
Activated but impaired IFN-γ production of mucosal-associated invariant T cells in patients with hepatocellular carcinoma
Wenyong Huang, Dongmei Ye, Wenjing He, Xiaoshun He, Xiaomin Shi, Yifang Gao

Journal for ImmunoTherapy of Cancer Nov 2021, 9 (11) e003685; DOI: 10.1136/jitc-2021-003685
Metformin improves cancer immunotherapy by directly rescuing tumor-infiltrating CD8 T lymphocytes from hypoxia-induced immunosuppression
Veronica Finisguerra, Tereza Dvorakova, Matteo Formenti, Pierre Van Meerbeeck, Lionel Mignion, Bernard Gallez, Benoit J Van den Eynde

Journal for ImmunoTherapy of Cancer May 2023, 11 (5) e005719; DOI: 10.1136/jitc-2022-005719

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