{"markup":"\u003C!DOCTYPE html PUBLIC \u0022-\/\/W3C\/\/DTD HTML 4.0 Transitional\/\/EN\u0022 \u0022http:\/\/www.w3.org\/TR\/REC-html40\/loose.dtd\u0022\u003E\n\u003C?xml version=\u00221.0\u0022 encoding=\u0022UTF-8\u0022 ?\u003E\u003Chtml version=\u0022HTML+RDFa+MathML 1.1\u0022 content=\u0022http:\/\/purl.org\/rss\/1.0\/modules\/content\/\u0022 dc=\u0022http:\/\/purl.org\/dc\/terms\/\u0022 foaf=\u0022http:\/\/xmlns.com\/foaf\/0.1\/\u0022 og=\u0022http:\/\/ogp.me\/ns#\u0022 rdfs=\u0022http:\/\/www.w3.org\/2000\/01\/rdf-schema#\u0022 sioc=\u0022http:\/\/rdfs.org\/sioc\/ns#\u0022 sioct=\u0022http:\/\/rdfs.org\/sioc\/types#\u0022 skos=\u0022http:\/\/www.w3.org\/2004\/02\/skos\/core#\u0022 xsd=\u0022http:\/\/www.w3.org\/2001\/XMLSchema#\u0022 mml=\u0022http:\/\/www.w3.org\/1998\/Math\/MathML\u0022\u003E\u003Chead\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\ngoogletag.slots[\u0022mpu\u0022] = googletag.defineSlot(\u0022\/21798771943\/JITC-MPU\u0022, [[300, 250], [300, 600], [300, 300], [600, 500]], \u0022dfp-ad-mpu\u0022)\n  .addService(googletag.pubads());\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022https:\/\/d1bxh8uas1mnw7.cloudfront.net\/assets\/embed.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/www.highwirestage.com\/sites\/default\/files\/js\/js_U2pncm4Q4A7IJl4J_deoOoy8h9tU-3gxfOF4iwZdk_g.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\njQuery.extend(Drupal.settings, {\u0022basePath\u0022:\u0022\\\/\u0022,\u0022pathPrefix\u0022:\u0022\u0022,\u0022panels_ajax_pane\u0022:{\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022:\u0022{\\u0022encrypted\\u0022:\\u0022{\\\\\\u0022encrypted\\\\\\u0022:\\\\\\u0022Wy95EIFww0FGtsH3WaWRReZSKUgukeuAHytdNvVNC1xnX\\\\\\\\\\\\\\\/m6arPcQPI+UIOmfvY2jRf6Yh8pzsju6qCQMXEAbRbyTtssrFhcKmmDborFNoogEM6Z34P3km\\\\\\\\\\\\\\\/2xnvskqSO9h72q6wFdmkH+0UNQNXSBNv+M5qPG9f\\\\\\\\\\\\\\\/rb6q1MLbTHwFsiZKlGZNWiSv+ob+5TUOfsVrE499lBPW37WBU0GNMqjVJ44l3QzvKCY7SAbpNtz0FKBxFpqp0y4SxQLwtxS35R965vcBekcBnllpQDARL1l6AWFW7TtpWK81gCw0FImidrjXALTPP3xHdqKyM57abIFNuGbLF7jFiKwddU\\\\\\\\\\\\\\\/ns9vpvIq5Z4Cl1Bjy1Sd9nk1VcWrGYuti5ruFGWoLxCoFYgpBab4owBY6iQ4akMVQc5fz77JdEU0v90NINTEkXlQQToa+HOPVbjMwOFkhQ31L2+H1kcY+eC90WZqgkka+6ZJRS4otLOStDaRNnVQBdyZ5PMYUHv5WVXYDlL4dny6a9akSYj7ND0bK8um0fQLlj5x0baeeLw\\\\\\\\\\\\\\\/3kVkQDFqZ38H71YTx1sHApt4e0x1KejHMcME9xFRG+KDPvYLFPsSAin76iaS3y9a+IfFNbVbLz0LAOP14Q6T5U74FUX0GEeaT0RV3lb3EdniaU5UDb91m9BWDeNTqaZ1uy7yO28kIas8CHRjODPGAymN82GnoikicZT\\\\\\\\\\\\\\\/8DeXl2UGimVwAy2Mixn4cX\\\\\\\\\\\\\\\/RKwvpkBgb73wmagI\\\\\\\\\\\\\\\/ccoE64pwxfig3R3fztPGWgnppjuJJXAlCsKNtSFZ\\\\\\\\\\\\\\\/TcUaEXWS4e+gAGR2Yf8za0Mq57oJ2KvJxoI7xVHBMuXHe1Uc4vNg\\\\\\\\\\\\\\\/dlle82FdD3oGt6lpzGD3blfXIvO5QH8VgJmMH25qcEfcbxV7NuoseX5OtF+QVry6+S1b4tZnkn1Ds1w8Vrh8aO95jFJxg9yaKYnk6msIILjlgP16juN0a4m1vOxIpC3zIsK2br9nAF4lRgnbFAr+Mtg+FYSXwzTKnnxDeiF6uc\\\\\\\\\\\\\\\/j\\\\\\\\\\\\\\\/qyf8Ek0fHmNs2\\\\\\\\\\\\\\\/aVlHOMPOn6sL0tBXo76dxRC47D6RaNcseBV0wn3SHq7dMXYYfk5o9MK53zG1Irk\\\\\\\\\\\\\\\/bhL+5adHLv6KYlZ4W528nSPBApLT1GGqvUQHfUiAgfum3SY\\\\\\\\\\\\\\\/UMWTws0LFWmIkMqokFX\\\\\\\\\\\\\\\/7\\\\\\\\\\\\\\\/XsL2XJWkvEZSIwet+w7M569Z2UepAbqk4\\\\\\\\\\\\\\\/a460+BYS4aEsPQ5F07bjQCKt05jkWw\\\\\\\\\\\\\\\/lOU9u7w0y+qKhjWuBTl5KyPKB2X2dPbQrXCZ+BPRe98hhoD6e5iJHGgeMcyIYtsk5rZv2EJtQBhB6KEcM0INpM6UxDizovoTJNtEb4RAoJGWxDXikUWPtOP0vEuWJIpzHXx6+\\\\\\\\\\\\\\\/UvKCUDPq9RXJlQS77A1Gi+\\\\\\\\\\\\\\\/EvibghRvvglzYcgSTlURcuAW+F8jkXQS2TbmCfvBLBl1csYRlDVo\\\\\\\\\\\\\\\/kJ7oeQ5c0RubHYsAysLetcWMpuFZvS0+pzpuMVuQJKSXid84GGdZ1AyQ3ioAK0H8NXDLC1sssCxv2qGLC16jhACWLZ9AcxkpmVoSHr+gUSD5mJVr6AAcHyENR37q1VByOOxL5mW16gFe2D+ui67DvddCFe\\\\\\\\\\\\\\\/9RmaZIZ53uphvKRxrbLg5tJlih9QjTN3Oinxej1wm5wnaJIdWTPN\\\\\\\\\\\\\\\/DrKbN\\\\\\\\\\\\\\\/QAeEGDFdQDA53kZMj8ZoIaCxU8WhU6qZur46K9s3ZYRiKWHAfvj9I12A0otuWqZFOB5yV66WK\\\\\\\\\\\\\\\/KdPLLka\\\\\\\\\\\\\\\/uOazmbgRhBNxK3yXSRhR4gxOoAA81Stc\\\\\\\\\\\\\\\/FpPQyIfoBpJPntq+jcVMNmFy\\\\\\\\\\\\\\\/ylchwyCAFJqeL2vY3pAiY3DNZ+tvSKgm+bs7MGmaQtngKWjC+svZXPd80PU6iTZc3LiexiSLb3yF+bglwWrhQ6O\\\\\\\\\\\\\\\/RhrUjCiBEsCWrEswGhxvw7kPb+Qwl36uzU3u7Etzsj8AfE\\\\\\\\\\\\\\\/BatTuC+QK5VFdbkKqSTvlJBv97oYClKC5\\\\\\\\\\\\\\\/ia+AMm55l26oSp0\\\\\\\\\\\\\\\/T+5N1jXE6XEkkksdTihu7U38dt13d\\\\\\\\\\\\\\\/7whFR3IVSsLBndRKrPAM0YCp7a5zokTetfUfTFTG3A7DmOylOCMcgvzyt2xN08e8p6phWhbrqTAj8EnpkBrX0qy2sb1D1W3FsBtQulXbNNa7imLYKRWOidrC6wYLqgGy1U+blEE\\\\\\\\\\\\\\\/dGKQ+UORx\\\\\\\\\\\\\\\/s2mF4fzAZJYmQqGSTk8sz2A5bzyFwYZjFzxu1ZRj6YWM5GMnDizweQFDcnKVUwxnCXFET5aiZkK\\\\\\\\\\\\\\\/t+OP3Jz4\\\\\\\\\\\\\\\/b9HUrG3rbuEcliZA4XW4rLwnxtXc1IqddVL4onmG38i0nzgDNVkRh8Uw66YmOvzr8j2NULMY1+RQmTFOFG3YJ2UeMlm2zxjlgSo3pCNYdgPDmFswjUu8TeMGZrxmwAtx+JNUFPxRNUb5Pq0asnwEe8Fjeypdl4fFE\\\\\\\\\\\\\\\/lMZE0hJNCcSLKd3sORlY00kc5tARcQRyEoyNa9KtYKtSedcZRTvECFbOMF1ERGRiyEZ8uJDe9MnTV9SjOLTSDRg1FSWCBVK0B5DOX2xRXiRVM0G21\\\\\\\\\\\\\\\/8ZO8dzi694+2GYqqkvLE6awLAej4\\\\\\\\\\\\\\\/\\\\\\\\\\\\\\\/RC89rGF0APsdCopFY+L+kW+1RyUNhzu8J3XluIDPIpeV+Q+kIIwBfvXQx1pg=\\\\\\u0022,\\\\\\u0022iv\\\\\\u0022:\\\\\\u0022\\\\\\\\\\\\\\\/nBL1BDxMBTETqdWQJAr2w==\\\\\\u0022,\\\\\\u0022salt\\\\\\u0022:\\\\\\u00223fcf69c0544933648ca27e63b3137e55\\\\\\u0022}\\u0022,\\u0022hmac\\u0022:\\u0022e30c19905363508f69963c95dc4e44b22a96df1a15a51cb9c0747975b30f72fa\\u0022}\u0022},\u0022highwire\u0022:{\u0022ac\u0022:{\u0022\\\/jitc\\\/7\\\/1\\\/15.atom\u0022:{\u0022access\u0022:{\u0022full\u0022:true,\u0022abstract\u0022:true},\u0022pisa_id\u0022:\u0022\u0022,\u0022apath\u0022:\u0022\\\/jitc\\\/7\\\/1\\\/15.atom\u0022,\u0022jcode\u0022:\u0022jitc\u0022}}},\u0022MutationObserver\u0022:{\u0022js\u0022:\u0022\\\/sites\\\/all\\\/libraries\\\/mutationobserver\\\/MutationObserver.js\u0022},\u0022ajaxPageState\u0022:{\u0022js\u0022:{\u00220\u0022:1,\u0022https:\\\/\\\/d1bxh8uas1mnw7.cloudfront.net\\\/assets\\\/embed.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/highwire\\\/highwire\\\/plugins\\\/content_types\\\/js\\\/highwire_altmetrics.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/contrib\\\/panels_ajax_pane\\\/panels_ajax_pane.js\u0022:1}}});\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Clink type=\u0022text\/css\u0022 rel=\u0022stylesheet\u0022 href=\u0022\/\/www.highwirestage.com\/sites\/default\/files\/advagg_css\/css__dn-cpI1YtkU_iLHgA5WhlkxgYWyat_IxjF_B-WSYrpE__a9hIbt0eaZ7d5nhwnm2weG8R_2eXK4EvoOx9dOxouHE__3qvfz4I9k5oUIeimOjbmdyh6ZgM-xweyVc5gub1_nR4.css\u0022 media=\u0022all\u0022\u003E\u003Clink rel=\u0022stylesheet\u0022 type=\u0022text\/css\u0022 href=\u0022\/sites\/all\/modules\/contrib\/panels\/plugins\/layouts\/onecol\/onecol.css\u0022\u003E\u003C\/head\u003E\u003Cbody\u003E\u003Cdiv class=\u0022panels-ajax-tab-panel panels-ajax-tab-panel-jnl-template-bmjj-tab-art\u0022\u003E\u003Cdiv class=\u0022panel-display panel-1col clearfix\u0022\u003E\n  \u003Cdiv class=\u0022panel-panel panel-col\u0022\u003E\n    \u003Cdiv\u003E\u003Cdiv class=\u0022panel-pane pane-dfp-pane oas-ads oas-ads-mid pull-right\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv id=\u0022dfp-ad-mpu-wrapper\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n\n\u003Cdiv id=\u0022dfp-ad-mpu\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n  \u003Cscript type=\u0022text\/javascript\u0022\u003E\n    googletag.cmd.push(function() {\n      googletag.display(\u0022dfp-ad-mpu\u0022);\n    });\n  \u003C\/script\u003E\u003C\/div\u003E\n\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-1\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003E\u003Ca href=\u0022https:\/\/doi.org\/10.1186\/s40425-018-0472-1\u0022 target=\u0022_new\u0022\u003Ehttps:\/\/doi.org\/10.1186\/s40425-018-0472-1\u003C\/a\u003E\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-altmetrics\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003EStatistics from Altmetric.com\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv data-badge-details=\u0022right\u0022 data-badge-type=\u0022medium-donut\u0022 data-doi=\u002210.1186\/s40425-018-0472-1\u0022 data-hide-no-mentions=\u0022true\u0022 class=\u0022altmetric-embed\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-2 permissions-box\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ERequest Permissions\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003EIf you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center\u0026rsquo;s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-panels-ajax-pane-content permissions-box pane-highwire-permission-link\u0022 id=\u0022request-permissions\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003E\u003Cspan class=\u0022panels-ajax-pane-title\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/span\u003E\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022panels-ajax-pane panels-ajax-pane-new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n  \u003C\/div\u003E\n\u003C\/div\u003E\n\u003C\/div\u003E\u003C\/body\u003E\u003C\/html\u003E\n"}