{"markup":"\u003C!DOCTYPE html PUBLIC \u0022-\/\/W3C\/\/DTD HTML 4.0 Transitional\/\/EN\u0022 \u0022http:\/\/www.w3.org\/TR\/REC-html40\/loose.dtd\u0022\u003E\n\u003C?xml version=\u00221.0\u0022 encoding=\u0022UTF-8\u0022 ?\u003E\u003Chtml version=\u0022HTML+RDFa+MathML 1.1\u0022 content=\u0022http:\/\/purl.org\/rss\/1.0\/modules\/content\/\u0022 dc=\u0022http:\/\/purl.org\/dc\/terms\/\u0022 foaf=\u0022http:\/\/xmlns.com\/foaf\/0.1\/\u0022 og=\u0022http:\/\/ogp.me\/ns#\u0022 rdfs=\u0022http:\/\/www.w3.org\/2000\/01\/rdf-schema#\u0022 sioc=\u0022http:\/\/rdfs.org\/sioc\/ns#\u0022 sioct=\u0022http:\/\/rdfs.org\/sioc\/types#\u0022 skos=\u0022http:\/\/www.w3.org\/2004\/02\/skos\/core#\u0022 xsd=\u0022http:\/\/www.w3.org\/2001\/XMLSchema#\u0022 mml=\u0022http:\/\/www.w3.org\/1998\/Math\/MathML\u0022\u003E\u003Chead\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\ngoogletag.slots[\u0022mpu\u0022] = googletag.defineSlot(\u0022\/21798771943\/JITC-MPU\u0022, [[300, 250], [300, 600], [300, 300], [600, 500]], \u0022dfp-ad-mpu\u0022)\n  .addService(googletag.pubads());\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022https:\/\/d1bxh8uas1mnw7.cloudfront.net\/assets\/embed.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/www.highwirestage.com\/sites\/default\/files\/js\/js_U2pncm4Q4A7IJl4J_deoOoy8h9tU-3gxfOF4iwZdk_g.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\njQuery.extend(Drupal.settings, {\u0022basePath\u0022:\u0022\\\/\u0022,\u0022pathPrefix\u0022:\u0022\u0022,\u0022panels_ajax_pane\u0022:{\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022:\u0022{\\u0022encrypted\\u0022:\\u0022{\\\\\\u0022encrypted\\\\\\u0022:\\\\\\u0022z3A7D1rXC4mLiHsEXLCRBzsq\\\\\\\\\\\\\\\/kJh9PWRI2HVIxRTVBu0JnPVsJIEafqzIPD9B9Vsqt\\\\\\\\\\\\\\\/zUqzE8tXUMzGD7\\\\\\\\\\\\\\\/Dc2N\\\\\\\\\\\\\\\/e90\\\\\\\\\\\\\\\/eGjOYZIu1ucJW1KClIpj96+CDgdlfytNLFJyalLJmyHzcR44QfBpYA3auDQBbwBqfqPl4UV2pMvSO0LskrBDISi104i+pdiQV\\\\\\\\\\\\\\\/vErGNXOa5QLKBQYbEn4e9Uqtu2B4VxIRR21bOLJ8C567SEfVMpILVFepZ0B5IEuote9lGPmgmiBNtYX49AhpttwP0LTaFv4U9gNr3eDN8ntGfqp+3rGD2ywftqBGUXnrURuqKOUb2Sngwo2U6wIcNtRWYTQJ33psMHmgqYWm31+vJBzTUXJLW1UxBqVuwWty+KSp\\\\\\\\\\\\\\\/F1orncc\\\\\\\\\\\\\\\/3UVOwfUciiEymZi4DSlw8HAvpNN6piUC+6PLPLHdPy9oSi3jpNeMubf13oQjMK4vjLPLjBj4\\\\\\\\\\\\\\\/9fHcPmNm3GcLs07rdSXs+MUZ\\\\\\\\\\\\\\\/zEzw+c+2QrEFO5okLv2CGmsFUhI2iPb6mU73BGa2xwm0hr\\\\\\\\\\\\\\\/\\\\\\\\\\\\\\\/OFJIY2mbBMgLFQzYtXC8Oqeh5K4cWgCBCzJHoSXQiLg0qL5waEr\\\\\\\\\\\\\\\/I0YrJfSMmhWqyF0ub2efhjppfb2EW3KJXIfzsqq+OYKQa6PC8OPD2C3K5Z+FkBddVoqRSQyijWWhBIicCY2qRIf8U7RyX5CIxaGFb2ir5yDbi2sidShK0TS0qxl9ep+hadHyPJeGqQhUP\\\\\\\\\\\\\\\/DKYs1d5i2UhMbyg\\\\\\\\\\\\\\\/fsakpoNrScS3KaoGRMYKojdDqeJkkTbBlVpxgv2QkT\\\\\\\\\\\\\\\/q4kiIGnO1\\\\\\\\\\\\\\\/5v0KwNZtl8DC3AQIclCgR3btp5M6YlopISdcWTnVXJDFv4XxQNvDRYBH2sNVyCY6p0LA9eIN74WY15vBOMpgm\\\\\\\\\\\\\\\/yo1JuSGUWRLx4FbvKWYljAoHdbhuzPuGyZpVAOSzrcexOVR5vwEsHgWRQO15hrUrI1h9X3xkzNxnyIv8ffieZcr4fFB6fVKa7YgfFFYxBIMT3CCF2XIQnGgZFpkIfoilNfPc8Oy0Zj3HmfFfTeSc6c+9kazBkildDK6cNSp5IrfncVbRWU55fnWc06zP1iJzI6hCn0GGeJLMBs+TTXUwbebQJ\\\\\\\\\\\\\\\/+aSjY5pl\\\\\\\\\\\\\\\/lW7A2IF1QhUVa8as3Jj7XdKOBrbS7FOTT2j0tl9TxvfSx+RXT1lg+kNes7vqATXvVbY8wi9DG2mRILPFy8S0PCSixLBWyo3wDB6iI8q0J8FqERqw9TWRZ1c67WroHWqtGm+PDS1bNMvJIR+oTY4TbQQm\\\\\\\\\\\\\\\/UkIN3nMmqsWv2cPhbtyeIv9OI4M0AYFTPjmvP\\\\\\\\\\\\\\\/S1kyi74pnDXqusd3YuC4C9VuAn9OBbeSED4LT1QflCX5zWPk5x2TT7qutO8BdTkX8c4XSn+oz2d7ZixSnHCgbbCqcIsZPiksMbG431RVHjMflthyQ4\\\\\\\\\\\\\\\/\\\\\\\\\\\\\\\/1ArokcEz821OdETVsBnwKwFE35Qlk82qr9Qe\\\\\\\\\\\\\\\/BhDJ4s5OEpS+0tsmWTjkBOFU9vXjSaTmuJFCEvbX6smyo7NDl4nY469WJ5TAUDovl\\\\\\\\\\\\\\\/knigwIpxaK+qA8ciqad\\\\\\\\\\\\\\\/\\\\\\\\\\\\\\\/WTbuYOIKJhhKyGtVTReWacac4uX43BaseA4\\\\\\\\\\\\\\\/A5uykeobMl55qQBUmymJNKY1MQA9huLjUckuurF51cWAyrzXflPguvl50jApmbJSpDOeFkjwjNg+SFYGCtWSQnhFmDCqyPRGhrPBDBuyq46nxCqVA3kSAbd3I5RA1FqxlYFafJ4NkvN\\\\\\\\\\\\\\\/qYsqer9M\\\\\\\\\\\\\\\/7s7Kckd6yfYP+Y51oQivt0vLATMbIaNyN\\\\\\\\\\\\\\\/9xjiyGL7AYh\\\\\\\\\\\\\\\/VuL9pqlwjVgot5f7RnDHbliQRMO9L0eCMBmEXYp2OvmrCkdF\\\\\\\\\\\\\\\/62qTPpaWyuhuNzcYeTTbVFURhOW2vM6YPe6Sc0K58DGvSLXQwxoM52AAIkN2c2XKYIEedglgzMCoSYq41vqIRiF8T7poot6XguWyONUHI4bwp2vCApG1fYvE3IKcWiaEtI9G2uWz5A4FYuHEqzeEFF4wAVhVGVXGGsT3gG0idykWRHhyWhctv9ZOjCxWu3l47CxkbNsLwJDG9tqbJBJdZso7NVIkY8FXDfBqKDquFDlgoXfvUcV\\\\\\\\\\\\\\\/MImXa6qEb3swBqWQQ9exTbRMB87pX\\\\\\\\\\\\\\\/em4vrky2Boz7+WUy50MWjNIgb1Fkg+GnYwLd3OMmyz6XwwVlYYMR04h7FBws46Y09PRi6KIkncKu8fYV58UBEx5TZpZpnbga54GxsT4LtpJRiLA3qWcoHZ6+Z1RoIj1KEvBalx2kX2\\\\\\\\\\\\\\\/+qw+Y8bqz4dICgZz8cNHRNzt6Lkt4cyEwSK2qS2okSDpNyxApQdR8bNEIiItN4+QPjvewGomQwMltuiG55pctWgmog2jgKiIKJcEtICP6eUpOb5uI9bRqvWeEbg3Ry30ZYmM7EHO5DBge8ZOOwmShGF4eLikORrzqw0iPJ2OkTmGN64odYOSztcMPkpvStsVx5y+83Z19B2RO8W6WyAn3wHgL0qR6RK8IOtFd6F6qfY+ZzS+MiS4IWDb0krt+roc7BeFdnHFeAefJcusunqA0nxbGL1f7Uw7dks6Zy9v9T+LwsmnTBSx8PwSVYEzofz4u1MdgqzUY418WQpqd7Z8pfkl07XqNtMK3mQrrXxY5cM=\\\\\\u0022,\\\\\\u0022iv\\\\\\u0022:\\\\\\u00224Klx62wInbk4vnINmZ\\\\\\\\\\\\\\\/pBg==\\\\\\u0022,\\\\\\u0022salt\\\\\\u0022:\\\\\\u00223fcf69c0544933648ca27e63b3137e55\\\\\\u0022}\\u0022,\\u0022hmac\\u0022:\\u0022fabc8bfd6e5815da143187acd74f869a19ebe05bb4a5e571f70fecae6a2b4214\\u0022}\u0022},\u0022highwire\u0022:{\u0022ac\u0022:{\u0022\\\/jitc\\\/7\\\/1\\\/6.atom\u0022:{\u0022access\u0022:{\u0022full\u0022:true,\u0022abstract\u0022:true},\u0022pisa_id\u0022:\u0022\u0022,\u0022apath\u0022:\u0022\\\/jitc\\\/7\\\/1\\\/6.atom\u0022,\u0022jcode\u0022:\u0022jitc\u0022}}},\u0022MutationObserver\u0022:{\u0022js\u0022:\u0022\\\/sites\\\/all\\\/libraries\\\/mutationobserver\\\/MutationObserver.js\u0022},\u0022ajaxPageState\u0022:{\u0022js\u0022:{\u00220\u0022:1,\u0022https:\\\/\\\/d1bxh8uas1mnw7.cloudfront.net\\\/assets\\\/embed.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/highwire\\\/highwire\\\/plugins\\\/content_types\\\/js\\\/highwire_altmetrics.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/contrib\\\/panels_ajax_pane\\\/panels_ajax_pane.js\u0022:1}}});\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Clink type=\u0022text\/css\u0022 rel=\u0022stylesheet\u0022 href=\u0022\/\/www.highwirestage.com\/sites\/default\/files\/advagg_css\/css__dn-cpI1YtkU_iLHgA5WhlkxgYWyat_IxjF_B-WSYrpE__a9hIbt0eaZ7d5nhwnm2weG8R_2eXK4EvoOx9dOxouHE__3qvfz4I9k5oUIeimOjbmdyh6ZgM-xweyVc5gub1_nR4.css\u0022 media=\u0022all\u0022\u003E\u003Clink rel=\u0022stylesheet\u0022 type=\u0022text\/css\u0022 href=\u0022\/sites\/all\/modules\/contrib\/panels\/plugins\/layouts\/onecol\/onecol.css\u0022\u003E\u003C\/head\u003E\u003Cbody\u003E\u003Cdiv class=\u0022panels-ajax-tab-panel panels-ajax-tab-panel-jnl-template-bmjj-tab-art\u0022\u003E\u003Cdiv class=\u0022panel-display panel-1col clearfix\u0022\u003E\n  \u003Cdiv class=\u0022panel-panel panel-col\u0022\u003E\n    \u003Cdiv\u003E\u003Cdiv class=\u0022panel-pane pane-dfp-pane oas-ads oas-ads-mid pull-right\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv id=\u0022dfp-ad-mpu-wrapper\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n\n\u003Cdiv id=\u0022dfp-ad-mpu\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n  \u003Cscript type=\u0022text\/javascript\u0022\u003E\n    googletag.cmd.push(function() {\n      googletag.display(\u0022dfp-ad-mpu\u0022);\n    });\n  \u003C\/script\u003E\u003C\/div\u003E\n\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-1\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003E\u003Ca href=\u0022https:\/\/doi.org\/10.1186\/s40425-018-0495-7\u0022 target=\u0022_new\u0022\u003Ehttps:\/\/doi.org\/10.1186\/s40425-018-0495-7\u003C\/a\u003E\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-altmetrics\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003EStatistics from Altmetric.com\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv data-badge-details=\u0022right\u0022 data-badge-type=\u0022medium-donut\u0022 data-doi=\u002210.1186\/s40425-018-0495-7\u0022 data-hide-no-mentions=\u0022true\u0022 class=\u0022altmetric-embed\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-2 permissions-box\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ERequest Permissions\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003EIf you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center\u0026rsquo;s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-panels-ajax-pane-content permissions-box pane-highwire-permission-link\u0022 id=\u0022request-permissions\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003E\u003Cspan class=\u0022panels-ajax-pane-title\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/span\u003E\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022panels-ajax-pane panels-ajax-pane-new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n  \u003C\/div\u003E\n\u003C\/div\u003E\n\u003C\/div\u003E\u003C\/body\u003E\u003C\/html\u003E\n"}