{"markup":"\u003C!DOCTYPE html PUBLIC \u0022-\/\/W3C\/\/DTD HTML 4.0 Transitional\/\/EN\u0022 \u0022http:\/\/www.w3.org\/TR\/REC-html40\/loose.dtd\u0022\u003E\n\u003C?xml version=\u00221.0\u0022 encoding=\u0022UTF-8\u0022 ?\u003E\u003Chtml version=\u0022HTML+RDFa+MathML 1.1\u0022 content=\u0022http:\/\/purl.org\/rss\/1.0\/modules\/content\/\u0022 dc=\u0022http:\/\/purl.org\/dc\/terms\/\u0022 foaf=\u0022http:\/\/xmlns.com\/foaf\/0.1\/\u0022 og=\u0022http:\/\/ogp.me\/ns#\u0022 rdfs=\u0022http:\/\/www.w3.org\/2000\/01\/rdf-schema#\u0022 sioc=\u0022http:\/\/rdfs.org\/sioc\/ns#\u0022 sioct=\u0022http:\/\/rdfs.org\/sioc\/types#\u0022 skos=\u0022http:\/\/www.w3.org\/2004\/02\/skos\/core#\u0022 xsd=\u0022http:\/\/www.w3.org\/2001\/XMLSchema#\u0022 mml=\u0022http:\/\/www.w3.org\/1998\/Math\/MathML\u0022\u003E\u003Chead\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\ngoogletag.slots[\u0022mpu\u0022] = googletag.defineSlot(\u0022\/21798771943\/JITC-MPU\u0022, [[300, 250], [300, 600], [300, 300], [600, 500]], \u0022dfp-ad-mpu\u0022)\n  .addService(googletag.pubads());\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022https:\/\/d1bxh8uas1mnw7.cloudfront.net\/assets\/embed.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/www.highwirestage.com\/sites\/default\/files\/js\/js_U2pncm4Q4A7IJl4J_deoOoy8h9tU-3gxfOF4iwZdk_g.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\njQuery.extend(Drupal.settings, {\u0022basePath\u0022:\u0022\\\/\u0022,\u0022pathPrefix\u0022:\u0022\u0022,\u0022panels_ajax_pane\u0022:{\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022:\u0022{\\u0022encrypted\\u0022:\\u0022{\\\\\\u0022encrypted\\\\\\u0022:\\\\\\u0022ZZtxoQ44DN45LAJAahyfAADQsCp2blhLXA5NKhM1z1EQrN98CcvTz3ytruBgE6tZ8s8wzdwG4rZAKSX+XeR28qEUaKRK0KFVQsw2\\\\\\\\\\\\\\\/WapSIUCEQ0yAhpYLbs1SXvTYlNp2tmwP02VsiFPAEhYZnhSyDvObGeV5cm+A2BywsIEz9RP3XjMPDiacbpCMNV4Ktk05Ykl06r2Fop7O1GPhcndoiQdu+xXUglw6TjKk4TddAuQKDucf83rgPx\\\\\\\\\\\\\\\/bINXRvfNy8c1J5yG4tkLy\\\\\\\\\\\\\\\/c+6NovMei+cr5Wx6gF2L+HA4ruSaIx0XLkI7hgyyruZ6IZKAL6LRxY0JU\\\\\\\\\\\\\\\/PMwZJ8Ri69Y31SOshEPuh\\\\\\\\\\\\\\\/TV8w79dY\\\\\\\\\\\\\\\/DPNZnQF2QfhBu6TzIzqRRs9zhcfM7mjD0vvJ\\\\\\\\\\\\\\\/0nhfPY6ncrrvp32ibGVq6jjX013VkUOA+6mzMl+lvBFTFjIEVCpiuQp\\\\\\\\\\\\\\\/y4MQvHOfE8ngYc94X9DzKyZaJRw7PtncNdHcmHPfS36Fu2lj9BOkMQKhLA5wRbNVHIiRC8x3gyEJL9davf+Ncl9E7Ee8NyB5sWyeiaXZ6H3hIPc35ARfBqupjBEtI8hZzLNbcuHZtmkNX5FUhqjPOrbaacFf\\\\\\\\\\\\\\\/pgEBAbIvI2076jBf3QRsX6XjRoAiEuEhrYOsALOXh+Y19TzvnW4ZpZF7N\\\\\\\\\\\\\\\/cLsmJhMmxeBQDmhXcpVF1GYaQfUlts0Jm\\\\\\\\\\\\\\\/t6lxy9XD7HGlWjEpzctMixSUhoTcamXNqb6CfZOLIvJWGx7w6SYCUJafnUzPZW4L68w8HvTNhvp7JIABLHcQQQZEo7yOpFAZiTBzrHPO0nNJH0pSpYgQwHaZe\\\\\\\\\\\\\\\/DJMgiHktIfDMylF8D7wto9i4av0sRejdXj8GIvIK9InBela9NU\\\\\\\\\\\\\\\/+IHvydxK8zQeERFmCqhqoWQiCnBaHFi28gUSfZXa95EbdH0w3nYnHY+PVF1YiJo6W1lf+IFMypAK\\\\\\\\\\\\\\\/aKGNLeIvo+T6BshilUk8Wd2JFO+WBCVIGroR6fszg7vLF2rp4bm6bHw4L+BD2TlYSmw57TXowQwwze8bgLrEn7Vu5ILxrUM40\\\\\\\\\\\\\\\/\\\\\\\\\\\\\\\/Jz8OaKZV6gDAifR1GR0nj5CFwV5TU9Vp9zZMzeADhdc3CLDSD92gqPcgvZZ0TFRIkCFSMgYDUSEQ1VClvNsNlkpJen6TfGNK1C\\\\\\\\\\\\\\\/YNms1RifT1rWthJF3pOWGRtdW7MABmp6yk6eN5wCte1IhM0QtfOzM75dhYj2rRZat27mfeTxgIq+eLYyGiGi55CiBMG5KCeZAPa9ziMMwadzHTU0dZz4ynVnc6HpMBt4gTUWG4Y9Mby+tlOBlsLWPi840UEKVgCLjgyEM4v1wPFf2ROF6\\\\\\\\\\\\\\\/CywnbOHrbnxc2foItfcaAsyYy9wYcJ7STUlr9n1qPo7u7SKNtaDuzDSkVPvU9TOGFIn4Jzrrs7616R77zcUEE6V9OTqhLnfQmnId99BW6BJhi0QGGRDpqG7KEeTTZyrKpMmVmrDcRqlp19XxzvbZjNYxDYTgveIRHa8bKwoGDCWryxxauHX0diAGc0Ozaxx2vcGv4\\\\\\\\\\\\\\\/dShbr8J9\\\\\\\\\\\\\\\/gNR8hUzvrOhNlxfP71bF7hSUZ6GBoB\\\\\\\\\\\\\\\/7uqqpe\\\\\\\\\\\\\\\/RXjrLFFWhp5EmJuKJjQc4gjtdWXXOrfrFChRWtHOBFf\\\\\\\\\\\\\\\/CDJS+f5XPmyzHJeUSihyWG8CyctWEr6cUS6Oj5VeBOqa9r9C2ZLzDzkFeQj8vLGjG9uAWF\\\\\\\\\\\\\\\/cQNoyZ+3ekodaoC21pGjaGD3EXXUrzWXy3fSEd0bipQaNWfJzqRiO1MOBrNOr8Y94Mqdx2nDXECWj3ktr6D90YaMvWAvFye0oGQL7FJOvbwFYqEb+kEiFonlF6+osHuWj9NVtJpgKlb4WfnG6joXrADdnV7a3O8mYclAPXv7hK7QY9MB151+rDI50q+uaxwc25dSgr7b+pluiXKaJytZKnqNXp1DvNVy4rrAbvI0Vz7N8cWVYV2+jVYMFTdhwbpreuP7t5qP5CElooXeis5UZURV6Entb8q3RqoVVcbxb\\\\\\\\\\\\\\\/\\\\\\\\\\\\\\\/SItw\\\\\\\\\\\\\\\/p\\\\\\\\\\\\\\\/+iO\\\\\\\\\\\\\\\/+bpfyRVbj4UyyeLzxvHmUW3S53j05s5pyVCPoZ0\\\\\\\\\\\\\\\/\\\\\\\\\\\\\\\/YccFLrS\\\\\\\\\\\\\\\/suAMQ2CZNnPQ5LWn3SCjiG0rYzIkaHOFabxDkyB3IdJQ\\\\\\\\\\\\\\\/efg4jz8kkFeOg2ZdREgRWZshnxonjcIo8e03CXdwy5GDagQ5CC16j2me0FpJvR1hCuaWlclTBCVOfi944\\\\\\\\\\\\\\\/WS4Ia28hwSeXooCJMcp1UXbZKhmRaLPePrrU2f9SIV0gXawoO8iIFrxOhzAypz6tIDpvx8JmWJSIebuHlX3pESrO07Jgw4jmuaqKFfB+ur1wve+jpAyxb2Wv9DxvYigq9hRqX4ew3c1v6ozGUzg9j68tuccTOoqJ9vQBwWpmDmwm9KP1CR1YBV2XnvLxvDp560hINqpZvP6b\\\\\\\\\\\\\\\/F0GeJfik6mFL1qqqeUUil6SPGH2yEcDC0G0bi\\\\\\\\\\\\\\\/iQz1I6UKLA8AnVhVQyGLGdONjoRmQtY7nqNpylRoO10TMQs89FeFUkvkrDy3HaN4PxDgRM4U8AUFYdFeKZSp8tI4dKzlJMJ0hBXBNiFZVvln3RT0TJWw8ovowe8LbHHLppxy4tRlTkeWFpCxJaelHN\\\\\\\\\\\\\\\/J2owZUd7mr7C8V5PI\\\\\\\\\\\\\\\/hVqiyk6kYyDTT15mgM=\\\\\\u0022,\\\\\\u0022iv\\\\\\u0022:\\\\\\u0022\\\\\\\\\\\\\\\/PN27H3YMxzuXiy1wEqkYQ==\\\\\\u0022,\\\\\\u0022salt\\\\\\u0022:\\\\\\u00223fcf69c0544933648ca27e63b3137e55\\\\\\u0022}\\u0022,\\u0022hmac\\u0022:\\u0022e5fffe9b860b9697f1212b66b2ed1e2b7a7b3a332da44d89764f5710f03a6f1e\\u0022}\u0022},\u0022highwire\u0022:{\u0022ac\u0022:{\u0022\\\/jitc\\\/7\\\/1\\\/45.atom\u0022:{\u0022access\u0022:{\u0022full\u0022:true,\u0022abstract\u0022:true},\u0022pisa_id\u0022:\u0022\u0022,\u0022apath\u0022:\u0022\\\/jitc\\\/7\\\/1\\\/45.atom\u0022,\u0022jcode\u0022:\u0022jitc\u0022}}},\u0022MutationObserver\u0022:{\u0022js\u0022:\u0022\\\/sites\\\/all\\\/libraries\\\/mutationobserver\\\/MutationObserver.js\u0022},\u0022ajaxPageState\u0022:{\u0022js\u0022:{\u00220\u0022:1,\u0022https:\\\/\\\/d1bxh8uas1mnw7.cloudfront.net\\\/assets\\\/embed.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/highwire\\\/highwire\\\/plugins\\\/content_types\\\/js\\\/highwire_altmetrics.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/contrib\\\/panels_ajax_pane\\\/panels_ajax_pane.js\u0022:1}}});\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Clink type=\u0022text\/css\u0022 rel=\u0022stylesheet\u0022 href=\u0022\/\/www.highwirestage.com\/sites\/default\/files\/advagg_css\/css__dn-cpI1YtkU_iLHgA5WhlkxgYWyat_IxjF_B-WSYrpE__a9hIbt0eaZ7d5nhwnm2weG8R_2eXK4EvoOx9dOxouHE__3qvfz4I9k5oUIeimOjbmdyh6ZgM-xweyVc5gub1_nR4.css\u0022 media=\u0022all\u0022\u003E\u003Clink rel=\u0022stylesheet\u0022 type=\u0022text\/css\u0022 href=\u0022\/sites\/all\/modules\/contrib\/panels\/plugins\/layouts\/onecol\/onecol.css\u0022\u003E\u003C\/head\u003E\u003Cbody\u003E\u003Cdiv class=\u0022panels-ajax-tab-panel panels-ajax-tab-panel-jnl-template-bmjj-tab-art\u0022\u003E\u003Cdiv class=\u0022panel-display panel-1col clearfix\u0022\u003E\n  \u003Cdiv class=\u0022panel-panel panel-col\u0022\u003E\n    \u003Cdiv\u003E\u003Cdiv class=\u0022panel-pane pane-dfp-pane oas-ads oas-ads-mid pull-right\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv id=\u0022dfp-ad-mpu-wrapper\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n\n\u003Cdiv id=\u0022dfp-ad-mpu\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n  \u003Cscript type=\u0022text\/javascript\u0022\u003E\n    googletag.cmd.push(function() {\n      googletag.display(\u0022dfp-ad-mpu\u0022);\n    });\n  \u003C\/script\u003E\u003C\/div\u003E\n\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-1\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003E\u003Ca href=\u0022https:\/\/doi.org\/10.1186\/s40425-019-0521-4\u0022 target=\u0022_new\u0022\u003Ehttps:\/\/doi.org\/10.1186\/s40425-019-0521-4\u003C\/a\u003E\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-altmetrics\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003EStatistics from Altmetric.com\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv data-badge-details=\u0022right\u0022 data-badge-type=\u0022medium-donut\u0022 data-doi=\u002210.1186\/s40425-019-0521-4\u0022 data-hide-no-mentions=\u0022true\u0022 class=\u0022altmetric-embed\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-2 permissions-box\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ERequest Permissions\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003EIf you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center\u0026rsquo;s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-panels-ajax-pane-content permissions-box pane-highwire-permission-link\u0022 id=\u0022request-permissions\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003E\u003Cspan class=\u0022panels-ajax-pane-title\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/span\u003E\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022panels-ajax-pane panels-ajax-pane-new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n  \u003C\/div\u003E\n\u003C\/div\u003E\n\u003C\/div\u003E\u003C\/body\u003E\u003C\/html\u003E\n"}