{"markup":"\u003C!DOCTYPE html PUBLIC \u0022-\/\/W3C\/\/DTD HTML 4.0 Transitional\/\/EN\u0022 \u0022http:\/\/www.w3.org\/TR\/REC-html40\/loose.dtd\u0022\u003E\n\u003C?xml version=\u00221.0\u0022 encoding=\u0022UTF-8\u0022 ?\u003E\u003Chtml version=\u0022HTML+RDFa+MathML 1.1\u0022 content=\u0022http:\/\/purl.org\/rss\/1.0\/modules\/content\/\u0022 dc=\u0022http:\/\/purl.org\/dc\/terms\/\u0022 foaf=\u0022http:\/\/xmlns.com\/foaf\/0.1\/\u0022 og=\u0022http:\/\/ogp.me\/ns#\u0022 rdfs=\u0022http:\/\/www.w3.org\/2000\/01\/rdf-schema#\u0022 sioc=\u0022http:\/\/rdfs.org\/sioc\/ns#\u0022 sioct=\u0022http:\/\/rdfs.org\/sioc\/types#\u0022 skos=\u0022http:\/\/www.w3.org\/2004\/02\/skos\/core#\u0022 xsd=\u0022http:\/\/www.w3.org\/2001\/XMLSchema#\u0022 mml=\u0022http:\/\/www.w3.org\/1998\/Math\/MathML\u0022\u003E\u003Chead\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\ngoogletag.slots[\u0022mpu\u0022] = googletag.defineSlot(\u0022\/21798771943\/JITC-MPU\u0022, [[300, 250], [300, 600], [300, 300], [600, 500]], \u0022dfp-ad-mpu\u0022)\n  .addService(googletag.pubads());\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022https:\/\/d1bxh8uas1mnw7.cloudfront.net\/assets\/embed.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/www.highwirestage.com\/sites\/default\/files\/js\/js_U2pncm4Q4A7IJl4J_deoOoy8h9tU-3gxfOF4iwZdk_g.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\njQuery.extend(Drupal.settings, {\u0022basePath\u0022:\u0022\\\/\u0022,\u0022pathPrefix\u0022:\u0022\u0022,\u0022panels_ajax_pane\u0022:{\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022:\u0022{\\u0022encrypted\\u0022:\\u0022{\\\\\\u0022encrypted\\\\\\u0022:\\\\\\u0022lTESNT4qygrjuBKH9+YL33aC5h9JpBWs4JEgiRZZrNSnOspQzhnhuB23GEhReeikwL\\\\\\\\\\\\\\\/fIppuGCh1WynDpwLa5Qp5iVStdXtOcsCamM6At\\\\\\\\\\\\\\\/2\\\\\\\\\\\\\\\/2wdu22yso4+0EoOnS9+YfOxt5IZfhJ+KTMwgaVsY\\\\\\\\\\\\\\\/bgLmP1FvGv4vSNCjpOj4EpoZQ4H6+nmcnLkSXnUpeUBBO6Em1kgRdvJXYHLJvFH4bnO\\\\\\\\\\\\\\\/IkN76pdsQ9H+umO33ML9pdRNE9uTb7zdmFDQxi\\\\\\\\\\\\\\\/3Tro+Dod7wL29Fz7kXRAsbZU+R7Cmi897mczsvFzw6JXmZlqu9gmx7fGbc1HtI9QJ7WdDCqx8RmF\\\\\\\\\\\\\\\/ldnEfYZ+aiFOwOO8cvIMTCvgXVG\\\\\\\\\\\\\\\/kbbyJQ752p+LD1rbH8eVo494Aj6ETsV+wes5njrHvbDvneESVLbhjny2KT8dZs+IimVdXjiYVcKWkMKdOrG8+JX9CLTyiH3QuwUN0VuFP6C4TPaHIvD6ebdxK8XiwUcENWCVDD2E495cHPnMlnZ79yfGy4nwbKR\\\\\\\\\\\\\\\/7Y0TDBx4dz0ales9vUY69vpPmoEy2k0Q7wYqDbUEyD1TqFnmke9lYQ2KYOmu5Vgs9Mt6kf7E0RKtsOrcYgNpxYT9pcfdqcNwwCvq7GkQ\\\\\\\\\\\\\\\/Nty25WY6ToqIFnPbEdzT0vYCjagmNFgtzphrDn1Q5uC1AmcaiUKM0wfFBE37LsBw\\\\\\\\\\\\\\\/UAdXAxsEfP2bh7+GPHr8H5pot8CgwO6SAtjTzS1gMK+XjnzHos5TrIMlqquIP7lAhg\\\\\\\\\\\\\\\/s55Zb+VmCJ1vm3HGSXnEYw5ji1pUGZnouyrdi973Mp7vL78XcrtJSYZhScn5yqYQRkqtVW0o3gGVhgbtYFXO3HC\\\\\\\\\\\\\\\/rQWLcRLwz+0C9oKrw5samZFqXevaljgxdRC8c10ovje+\\\\\\\\\\\\\\\/2F8uhozbCeDk2tqZ2u3n5YdvcdkNxyVf9pRZzrJ7nahRXWLBokDRgRv9A4Bh+WFxQEi+mVXP7lcCD7A51ImdBw85tzsRq2y0tljmk52jLIMjaVPXFr8yjRdUly+bOT+g2vptMq7n\\\\\\\\\\\\\\\/uaBL9mLAlCd+8IJtXxa8F+XGKm1my+0mQEYdTFH\\\\\\\\\\\\\\\/ClcabOcG6tiJaG3FyTio6Y1cb2rM2qvYgaUO5WRB3VUbYMAVgHIVSLPG5mJ\\\\\\\\\\\\\\\/+q9EEq5+d7vA0qmalWjf9F845PtWChsyISOsiLnllC8ZHaDAm0rztJ1g3jZ3Mg09d\\\\\\\\\\\\\\\/wbSCCjdMmHAC4EKu3rSQRU4taEVh9QFykhV4eyDfk0SKW5N6iQPNBYhtqv0LlWGGnaWRwKO6u9\\\\\\\\\\\\\\\/\\\\\\\\\\\\\\\/6h+e1aGtLqDUP5t3eNDVhcznF+kMcYdtbSB169Ciuqi8zkbk6qWu4d5LMUgdQqj7g7alDeiEKOl49hgDgw6DtjTD0yg2s1gKZcvEx6y+oK\\\\\\\\\\\\\\\/XYjH9vPwpCtww6Bo8zUD9lYXyLOZQrNsO7hqKtNZa9zFA7tMu2tCxP6MY0Ox4LIqbfp0hY4wtM\\\\\\\\\\\\\\\/ER8\\\\\\\\\\\\\\\/FbfBKEe86hB2TnU5h+of0exdNzt1N76lS2QjUQMAMphwwihV5KGKGL\\\\\\\\\\\\\\\/KJ2771wW3avMlce7FAf\\\\\\\\\\\\\\\/yt7C+9F8LbCsB2H5VHa0SkLP03zXDB1n8CSu8XtDx21hmlpmAEID9Veb020VdsM1reze6tW2g+2uNnNyZZQZUabEiYQ2odGvnDP0a9aVlVww7xDEXZxRn\\\\\\\\\\\\\\\/XewnW\\\\\\\\\\\\\\\/el7AJE3sTWdpMskDC+\\\\\\\\\\\\\\\/qN\\\\\\\\\\\\\\\/mvMm7ha2y7806aJUwL4SKYHKNG2Y\\\\\\\\\\\\\\\/3L0PGVHuqGq4YcrxPc1WVie2PU7IRLVXbVy1S7k7ENmyk7zQxK7S4RpSnMiv5SmwjITevitWVU088UoscMkmcGlYUxyYL63Y2vUfwkbgU8iXL1pJjNK2D2OC6hRKCSwU8Co\\\\\\\\\\\\\\\/zl2Bz3cTOGzgcGm7MOESzAC3CwA4PS9fUSPZdOz+y1pqb2H\\\\\\\\\\\\\\\/1krjLznPsLayvvqQe4zbW7P9JngbV94Ya+l+eUovTJoDaf5IzQFn9DtVTAY2ZayKi3bADVXThuZ5nPPDIBpIex53X\\\\\\\\\\\\\\\/5oJjOh3ynC\\\\\\\\\\\\\\\/JLfgYdzd0OTr0OF9FZ0GLDrk\\\\\\\\\\\\\\\/I0jhJ4JEy90tHKG\\\\\\\\\\\\\\\/3dfXByX0UoToUWbdUSWNX0p\\\\\\\\\\\\\\\/az\\\\\\\\\\\\\\\/5t5HnzNjA7Pt9eJ+07mI55fEPQzY1YeyjmNTZzBtaAYwJNvBnxf\\\\\\\\\\\\\\\/61W3k168LLoZOtl96FHisYvIa1Ah1lwjabulA+5Fj8CsmWfAeP7Jh6s5QZ0PL5U4DFp7XKJHMYcKc1dkIwondSItOt9aueje3sKVLQ0nQBD1MT\\\\\\\\\\\\\\\/H05YRaBOeFsrD+7S3q6odjmM7VVhUw9dtvi4fTOeU0JcNB1zlI3ClEjh3bds82f4MWQr+nPafZO64N8\\\\\\\\\\\\\\\/IkfHEkaNSdkVvSAOy6qzTG686w2ZP8F1OvcufIhxO5qIv6lOSErSepnW4AVCE\\\\\\\\\\\\\\\/DfsvMa2ZzTY6HAODKsyV1e1EGWymbeJ6qaF1pecjwm2LlddQARylFhzdukrzVeOp9bMDGfkYSDQvAD1A33c4Iptyuwa77hRXybGZ7mdJiVqGpr2KzPKPxU\\\\\\\\\\\\\\\/OIt+PtOn5JvzCkwfkTOhl3oR7kTghPLXjNkv3Uvo5oXAJh+sj6bc5vP9I50jExTM7Gjo+qJ2GEKRzPIl+YqSA7jQqpbyP6anSZQ1RgWug8mGLoAunHqBVWMK\\\\\\\\\\\\\\\/FZI=\\\\\\u0022,\\\\\\u0022iv\\\\\\u0022:\\\\\\u0022Ynr7mvHCVgQjbUOFZeN\\\\\\\\\\\\\\\/vw==\\\\\\u0022,\\\\\\u0022salt\\\\\\u0022:\\\\\\u00223fcf69c0544933648ca27e63b3137e55\\\\\\u0022}\\u0022,\\u0022hmac\\u0022:\\u00225f6292f6c5dfdc71c57023553e1fbe209d0bdeb0d72f77b2ce3ebf1de4f537c6\\u0022}\u0022},\u0022highwire\u0022:{\u0022ac\u0022:{\u0022\\\/jitc\\\/7\\\/1\\\/227.atom\u0022:{\u0022access\u0022:{\u0022full\u0022:true,\u0022abstract\u0022:true},\u0022pisa_id\u0022:\u0022\u0022,\u0022apath\u0022:\u0022\\\/jitc\\\/7\\\/1\\\/227.atom\u0022,\u0022jcode\u0022:\u0022jitc\u0022}}},\u0022MutationObserver\u0022:{\u0022js\u0022:\u0022\\\/sites\\\/all\\\/libraries\\\/mutationobserver\\\/MutationObserver.js\u0022},\u0022ajaxPageState\u0022:{\u0022js\u0022:{\u00220\u0022:1,\u0022https:\\\/\\\/d1bxh8uas1mnw7.cloudfront.net\\\/assets\\\/embed.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/highwire\\\/highwire\\\/plugins\\\/content_types\\\/js\\\/highwire_altmetrics.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/contrib\\\/panels_ajax_pane\\\/panels_ajax_pane.js\u0022:1}}});\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Clink type=\u0022text\/css\u0022 rel=\u0022stylesheet\u0022 href=\u0022\/\/www.highwirestage.com\/sites\/default\/files\/advagg_css\/css__dn-cpI1YtkU_iLHgA5WhlkxgYWyat_IxjF_B-WSYrpE__a9hIbt0eaZ7d5nhwnm2weG8R_2eXK4EvoOx9dOxouHE__3qvfz4I9k5oUIeimOjbmdyh6ZgM-xweyVc5gub1_nR4.css\u0022 media=\u0022all\u0022\u003E\u003Clink rel=\u0022stylesheet\u0022 type=\u0022text\/css\u0022 href=\u0022\/sites\/all\/modules\/contrib\/panels\/plugins\/layouts\/onecol\/onecol.css\u0022\u003E\u003C\/head\u003E\u003Cbody\u003E\u003Cdiv class=\u0022panels-ajax-tab-panel panels-ajax-tab-panel-jnl-template-bmjj-tab-art\u0022\u003E\u003Cdiv class=\u0022panel-display panel-1col clearfix\u0022\u003E\n  \u003Cdiv class=\u0022panel-panel panel-col\u0022\u003E\n    \u003Cdiv\u003E\u003Cdiv class=\u0022panel-pane pane-dfp-pane oas-ads oas-ads-mid pull-right\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv id=\u0022dfp-ad-mpu-wrapper\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n\n\u003Cdiv id=\u0022dfp-ad-mpu\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n  \u003Cscript type=\u0022text\/javascript\u0022\u003E\n    googletag.cmd.push(function() {\n      googletag.display(\u0022dfp-ad-mpu\u0022);\n    });\n  \u003C\/script\u003E\u003C\/div\u003E\n\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-1\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003E\u003Ca href=\u0022https:\/\/doi.org\/10.1186\/s40425-019-0710-1\u0022 target=\u0022_new\u0022\u003Ehttps:\/\/doi.org\/10.1186\/s40425-019-0710-1\u003C\/a\u003E\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-altmetrics\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003EStatistics from Altmetric.com\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv data-badge-details=\u0022right\u0022 data-badge-type=\u0022medium-donut\u0022 data-doi=\u002210.1186\/s40425-019-0710-1\u0022 data-hide-no-mentions=\u0022true\u0022 class=\u0022altmetric-embed\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-2 permissions-box\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ERequest Permissions\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003EIf you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center\u0026rsquo;s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-panels-ajax-pane-content permissions-box pane-highwire-permission-link\u0022 id=\u0022request-permissions\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003E\u003Cspan class=\u0022panels-ajax-pane-title\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/span\u003E\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022panels-ajax-pane panels-ajax-pane-new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n  \u003C\/div\u003E\n\u003C\/div\u003E\n\u003C\/div\u003E\u003C\/body\u003E\u003C\/html\u003E\n"}