{"markup":"\u003C!DOCTYPE html PUBLIC \u0022-\/\/W3C\/\/DTD HTML 4.0 Transitional\/\/EN\u0022 \u0022http:\/\/www.w3.org\/TR\/REC-html40\/loose.dtd\u0022\u003E\n\u003C?xml version=\u00221.0\u0022 encoding=\u0022UTF-8\u0022 ?\u003E\u003Chtml version=\u0022HTML+RDFa+MathML 1.1\u0022 content=\u0022http:\/\/purl.org\/rss\/1.0\/modules\/content\/\u0022 dc=\u0022http:\/\/purl.org\/dc\/terms\/\u0022 foaf=\u0022http:\/\/xmlns.com\/foaf\/0.1\/\u0022 og=\u0022http:\/\/ogp.me\/ns#\u0022 rdfs=\u0022http:\/\/www.w3.org\/2000\/01\/rdf-schema#\u0022 sioc=\u0022http:\/\/rdfs.org\/sioc\/ns#\u0022 sioct=\u0022http:\/\/rdfs.org\/sioc\/types#\u0022 skos=\u0022http:\/\/www.w3.org\/2004\/02\/skos\/core#\u0022 xsd=\u0022http:\/\/www.w3.org\/2001\/XMLSchema#\u0022 mml=\u0022http:\/\/www.w3.org\/1998\/Math\/MathML\u0022\u003E\u003Chead\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\ngoogletag.slots[\u0022mpu\u0022] = googletag.defineSlot(\u0022\/21798771943\/JITC-MPU\u0022, [[300, 250], [300, 600], [300, 300], [600, 500]], \u0022dfp-ad-mpu\u0022)\n  .addService(googletag.pubads());\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022https:\/\/d1bxh8uas1mnw7.cloudfront.net\/assets\/embed.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/www.highwirestage.com\/sites\/default\/files\/js\/js_U2pncm4Q4A7IJl4J_deoOoy8h9tU-3gxfOF4iwZdk_g.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\njQuery.extend(Drupal.settings, {\u0022basePath\u0022:\u0022\\\/\u0022,\u0022pathPrefix\u0022:\u0022\u0022,\u0022panels_ajax_pane\u0022:{\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022:\u0022{\\u0022encrypted\\u0022:\\u0022{\\\\\\u0022encrypted\\\\\\u0022:\\\\\\u00222G4fR5TJM5QbERfRShYVHLiiBvMdA\\\\\\\\\\\\\\\/Ke5jG274JnLln45Jf1yOhSBIC\\\\\\\\\\\\\\\/MoTDVoMguEoCracfYYJhZQ0d9t\\\\\\\\\\\\\\\/EatEnTI1g411zixNR+3BoZrEp08Ww54K\\\\\\\\\\\\\\\/gI9x75\\\\\\\\\\\\\\\/7kwkRMaVETZu42VpWvNa7ixOE2koj+NCUGv\\\\\\\\\\\\\\\/RAFqQG8gHLzolfZ+VWQ72HhBD60waIAwWlWcP3aaI3KtmmHNFx+Vb1lSfCipoHP+Ay32WiZcw3PuA6lFRu5m63ZSJ8+sPvJ0XX9k+toNstZODu3ZU4e8vMRei1e9Jx7NFbVCmWPJrR2RQYQgtEgOTTAtpfjC5VZOQWYSFmrVVZaoB90UrOvmn1kb0Svmm3okcVYx7fMiWwYlUA93wTUMi0LlDhug53KKM7XAinZWZNCRER6IT9LC3Iov+GjIvYc5bAYYbYp0s0SZl8N+msX+LCDCPMsr9OT8iFUyVq5luNkLFM7OXygC8UP80YVAwXj900RvRkIg45alFnG50YUlXFJlyrqo5\\\\\\\\\\\\\\\/LFlwkvR05hAATFAqZ3oIqMRLANNZ7YrHq6lDxvL+3QxnhgWMKxm\\\\\\\\\\\\\\\/6Bx2l82GuXVxhHjoaJ4Q0V8xEtAlARNQQ9ODAiwriLJ8oTQg\\\\\\\\\\\\\\\/LZFPMUjjfpYRDAhMnRBNJ0lkQf4B1QIg2iEtKnYL3Momy4l7UpxiM13aGXbpQY1gZCHsrpORhUKEKP47jTX98cArS9YYKp1cPYZvaxmGNdW2lgIWUDuscTpS8NgGdFXKEpj2M0ua6NLaIY9ANA7VHkPC64PjtOH\\\\\\\\\\\\\\\/mR1SGsgKD+\\\\\\\\\\\\\\\/eh4F1+URPyvXq52izQ8rhfgfd26Jyeh5eB3ywbsTux\\\\\\\\\\\\\\\/vpWMnGGIXHKWirZdWbWPxuRfU+homv9gozfRkRpbET8kQgIIFr3B4RHwVd8+Y55wm800pmbJ7C8LJ0nFFVcGTP02r7E0wicYfUsKfx8PyX\\\\\\\\\\\\\\\/+DwEG34oVDTVmrm2RGIoFGXUAtViUAyqRYZnLj7gWHAcvAfHpGyPs4cTxd+\\\\\\\\\\\\\\\/IWVv7d5+U9YJUbQ4MYidXjAFAUtNXhYk3QFIEiMTHHzB3WosmJFq8wrRZdEu+Q296jL4BR7TTjuQRnGL4GpCSadTGcHdOYUsvOYmQAqZAjWmMqLLW8iBZpYKmB2UJp\\\\\\\\\\\\\\\/3HY70tEg0kdbkFRWZNlVXkwLOg5GF5d6v36J5ZJVjxdDtuloZngeD0x+xhicEbJKrphi0YOdoO0uBgU8pjXgvgv1GHrHGqko\\\\\\\\\\\\\\\/Zn+EbBGAsGx2srDXKF8GLbBwMRL7CgOzPErZXPRaIM+LZcvpI1DsiBSQWMyEFj+yFh382+F4g34ECQ\\\\\\\\\\\\\\\/aKEaVPZ3PBCYyD3dVxiKtBolldFUte+tlOmiOdDXECZ7ex1sOVkxV0Bf6NBV3w1cAy4A7fvoaP1\\\\\\\\\\\\\\\/yDgsUYKI8PJIEnSbfWR0sOPwhf9UeKSd4UB5fx9c8jx+Zm0Aw00sHq8yaruuYLeHQMBCGIQK6bvy2y4qkPRw7Rx46tUu8hB4\\\\\\\\\\\\\\\/vXR\\\\\\\\\\\\\\\/fF\\\\\\\\\\\\\\\/9DWPuzEmoaW7aPyn5j94NA8EOkzihp14NXod0RiLhF28F5zTsITLyNniGLtIzXuKniqjUIDlBbeHErWK13IABlmWeluNS+Q4DunFncH32nWhPwrg+9BjBhyzxgQ2oF2NQEA8nbYv0RQOEUU9+pxofXr8CWtlLIHim7X0MDIdIyLKKvya0HcwxNsvaJGSLvwyd26aKauFTPh9D9NwlvCVXn7M6PWMquVgXztDYV38E\\\\\\\\\\\\\\\/u\\\\\\\\\\\\\\\/+RTzdVXDa5Ju+NZBN1vJauFn3G00bzFkM4iG4vpknfciDkooWWJ1z5a\\\\\\\\\\\\\\\/hVC3qSMUfrBgZSPQ7qIGLtehH3jv7ZCfO6lkV6dDv4x7ZD52JyuZ5SjavF6wb5\\\\\\\\\\\\\\\/Jt4giLgDYrXfwi9aSEdmUtraoTmSiiFH27E5vfeUanIdv9gZWLeu70Emlx8T3Mm6tmLOaHfF7CPTXYbCtFFpByzTeOawQeFOdHndXljhWOISI2csSZ5VDZW5Tz787oks+2cvDID6j2rpyzbkQSomaYS+R5+08S2Z0Wcuabdyo9w0iHb8ge\\\\\\\\\\\\\\\/qKYL5SCdvY\\\\\\\\\\\\\\\/A5XEMspAZ2Ki8uH2mUoeC+dC2jLK0uQtHNXWDTKoL6cOSdSWC8azhIEyvBfavc0Dv8SN96nxuHRawpA5SQzqmHIH8JT8SHkbiNbQW3y68j1p2NfF5c7K368X74bH1727ykiF+CXqBiglyksHQY6SOjYJNrLi0Sh+SDD6nSuTvVjjGg49Dl\\\\\\\\\\\\\\\/v84f4jdTth9p5nsHAkjjiR4Oe22FUYrBUby\\\\\\\\\\\\\\\/4qpyfb03a+10q0GDjgCc9eCSolXlr9xpo\\\\\\\\\\\\\\\/uiegLNNPmgDoDykv7qDfeJvWSkjeRK\\\\\\\\\\\\\\\/UiZ+0EuXJep2zZU7GCxjW+K85vLjOMrZbjnFgTrC9QIOPz0\\\\\\\\\\\\\\\/zqIE6Z3Eaq6+Ikn\\\\\\\\\\\\\\\/mbZ4xDygRe5E7lxcmd9FvQmbheJLq6fRSzr4h\\\\\\\\\\\\\\\/Sf4FcD3ogt31fuzBtce8CChCsfy7DSWirtc\\\\\\\\\\\\\\\/tg28XSlxcExk4sMdUcmXFjBiNvE9d3h2H4v+VdRMpk+q1+AJUsmnxJsgpUFX4qD9WDZgnFYmS98I7dUzp1qepsiEJVHrmVfWoCCh99CZGDjMWr7Ee6e2b0JUIuAIbTPJYhHeWROiwgJwUEWkc0ofPrUm0ntZVLLOAutgNQ=\\\\\\u0022,\\\\\\u0022iv\\\\\\u0022:\\\\\\u0022+SsoMfCYbA31OtvTZA1IgQ==\\\\\\u0022,\\\\\\u0022salt\\\\\\u0022:\\\\\\u00223fcf69c0544933648ca27e63b3137e55\\\\\\u0022}\\u0022,\\u0022hmac\\u0022:\\u0022661195554f3cd8cb6fbc399f2e62c5a7bb3bca71cc71173100726d85a5060929\\u0022}\u0022},\u0022highwire\u0022:{\u0022ac\u0022:{\u0022\\\/jitc\\\/7\\\/1\\\/171.atom\u0022:{\u0022access\u0022:{\u0022full\u0022:true,\u0022abstract\u0022:true},\u0022pisa_id\u0022:\u0022\u0022,\u0022apath\u0022:\u0022\\\/jitc\\\/7\\\/1\\\/171.atom\u0022,\u0022jcode\u0022:\u0022jitc\u0022}}},\u0022MutationObserver\u0022:{\u0022js\u0022:\u0022\\\/sites\\\/all\\\/libraries\\\/mutationobserver\\\/MutationObserver.js\u0022},\u0022ajaxPageState\u0022:{\u0022js\u0022:{\u00220\u0022:1,\u0022https:\\\/\\\/d1bxh8uas1mnw7.cloudfront.net\\\/assets\\\/embed.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/highwire\\\/highwire\\\/plugins\\\/content_types\\\/js\\\/highwire_altmetrics.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/contrib\\\/panels_ajax_pane\\\/panels_ajax_pane.js\u0022:1}}});\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Clink type=\u0022text\/css\u0022 rel=\u0022stylesheet\u0022 href=\u0022\/\/www.highwirestage.com\/sites\/default\/files\/advagg_css\/css__dn-cpI1YtkU_iLHgA5WhlkxgYWyat_IxjF_B-WSYrpE__a9hIbt0eaZ7d5nhwnm2weG8R_2eXK4EvoOx9dOxouHE__3qvfz4I9k5oUIeimOjbmdyh6ZgM-xweyVc5gub1_nR4.css\u0022 media=\u0022all\u0022\u003E\u003Clink rel=\u0022stylesheet\u0022 type=\u0022text\/css\u0022 href=\u0022\/sites\/all\/modules\/contrib\/panels\/plugins\/layouts\/onecol\/onecol.css\u0022\u003E\u003C\/head\u003E\u003Cbody\u003E\u003Cdiv class=\u0022panels-ajax-tab-panel panels-ajax-tab-panel-jnl-template-bmjj-tab-art\u0022\u003E\u003Cdiv class=\u0022panel-display panel-1col clearfix\u0022\u003E\n  \u003Cdiv class=\u0022panel-panel panel-col\u0022\u003E\n    \u003Cdiv\u003E\u003Cdiv class=\u0022panel-pane pane-dfp-pane oas-ads oas-ads-mid pull-right\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv id=\u0022dfp-ad-mpu-wrapper\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n\n\u003Cdiv id=\u0022dfp-ad-mpu\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n  \u003Cscript type=\u0022text\/javascript\u0022\u003E\n    googletag.cmd.push(function() {\n      googletag.display(\u0022dfp-ad-mpu\u0022);\n    });\n  \u003C\/script\u003E\u003C\/div\u003E\n\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-1\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003E\u003Ca href=\u0022https:\/\/doi.org\/10.1186\/s40425-019-0642-9\u0022 target=\u0022_new\u0022\u003Ehttps:\/\/doi.org\/10.1186\/s40425-019-0642-9\u003C\/a\u003E\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-altmetrics\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003EStatistics from Altmetric.com\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv data-badge-details=\u0022right\u0022 data-badge-type=\u0022medium-donut\u0022 data-doi=\u002210.1186\/s40425-019-0642-9\u0022 data-hide-no-mentions=\u0022true\u0022 class=\u0022altmetric-embed\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-2 permissions-box\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ERequest Permissions\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003EIf you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center\u0026rsquo;s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-panels-ajax-pane-content permissions-box pane-highwire-permission-link\u0022 id=\u0022request-permissions\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003E\u003Cspan class=\u0022panels-ajax-pane-title\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/span\u003E\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022panels-ajax-pane panels-ajax-pane-new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n  \u003C\/div\u003E\n\u003C\/div\u003E\n\u003C\/div\u003E\u003C\/body\u003E\u003C\/html\u003E\n"}