{"markup":"\u003C!DOCTYPE html PUBLIC \u0022-\/\/W3C\/\/DTD HTML 4.0 Transitional\/\/EN\u0022 \u0022http:\/\/www.w3.org\/TR\/REC-html40\/loose.dtd\u0022\u003E\n\u003C?xml version=\u00221.0\u0022 encoding=\u0022UTF-8\u0022 ?\u003E\u003Chtml version=\u0022HTML+RDFa+MathML 1.1\u0022 content=\u0022http:\/\/purl.org\/rss\/1.0\/modules\/content\/\u0022 dc=\u0022http:\/\/purl.org\/dc\/terms\/\u0022 foaf=\u0022http:\/\/xmlns.com\/foaf\/0.1\/\u0022 og=\u0022http:\/\/ogp.me\/ns#\u0022 rdfs=\u0022http:\/\/www.w3.org\/2000\/01\/rdf-schema#\u0022 sioc=\u0022http:\/\/rdfs.org\/sioc\/ns#\u0022 sioct=\u0022http:\/\/rdfs.org\/sioc\/types#\u0022 skos=\u0022http:\/\/www.w3.org\/2004\/02\/skos\/core#\u0022 xsd=\u0022http:\/\/www.w3.org\/2001\/XMLSchema#\u0022 mml=\u0022http:\/\/www.w3.org\/1998\/Math\/MathML\u0022\u003E\u003Chead\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\ngoogletag.slots[\u0022mpu\u0022] = googletag.defineSlot(\u0022\/21798771943\/JITC-MPU\u0022, [[300, 250], [300, 600], [300, 300], [600, 500]], \u0022dfp-ad-mpu\u0022)\n  .addService(googletag.pubads());\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022https:\/\/d1bxh8uas1mnw7.cloudfront.net\/assets\/embed.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/www.highwirestage.com\/sites\/default\/files\/js\/js_U2pncm4Q4A7IJl4J_deoOoy8h9tU-3gxfOF4iwZdk_g.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\njQuery.extend(Drupal.settings, {\u0022basePath\u0022:\u0022\\\/\u0022,\u0022pathPrefix\u0022:\u0022\u0022,\u0022panels_ajax_pane\u0022:{\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022:\u0022{\\u0022encrypted\\u0022:\\u0022{\\\\\\u0022encrypted\\\\\\u0022:\\\\\\u00223IP+s2L5i+jsVYUIWJKc\\\\\\\\\\\\\\\/jmgQYaV2Ue2MnBXnsmZWVAT0C8wuUMtW\\\\\\\\\\\\\\\/3bK7e82Aj53B6a+A\\\\\\\\\\\\\\\/8Cg99Ksh5tbb1cFpENbvGl\\\\\\\\\\\\\\\/a\\\\\\\\\\\\\\\/f0qPfa4glRICXIhZIYvDuBteulsFkrDzb6xE4BqVn1BBEx5xofLcOhRQED36Kz6lvcZGyFJP3vF0pUARFLeJhLxjwIVzWHPXA2q2vAUluY+OB4+5LHgXGIcGlHnT5eOfbBL4E7e0zjkWuBDt1eClK4Sc\\\\\\\\\\\\\\\/8pHbeXWEyg8c+3Wq2XYwm2oyA+TsT3y3MDjaNmOUlaONiBUTUVffJ03Yqu2lIpuxSXbgigpQ1XaKfrFGsRBvSYlclmTdILW4DxHlLo3cVN3x5Gd6\\\\\\\\\\\\\\\/KDMbLpZaESW9ZcddJY7PWIZKwiJhokZO+rY7uX2cEQxzpzqPO1+cTKNG352nLdRou++D8K7tpqbjJR1709yduoExk\\\\\\\\\\\\\\\/bnEqQmwLBLYDs4JEBkCtkjgTsJOSSk12\\\\\\\\\\\\\\\/msrwM+hKRXWQFNTXfhkoHpgTn+my5rsW3mXKuKxMkYkybO61LlIcYWsngvU491gfDKmnLzS4RUwHhxC0l0vzSJ5TH3Ss+y7W7m6iYATydi8rAe5v53gxVUTbCA3gnHRj2cARMTMyl0Aw2Vhe7vbqLcv30mItcw7p125aE1jH5Yp2tExn4XIn+Zv6VE6WUIaMtSKVHB64S3gCWRXu+jBP3r9XZCcAVQ0ul7ruT6MaCBhlCnLISstV+ibJqAaQNPPodn5edSXNtw+xGcxw4x5U20FG26kJsWeuG2tEBoH\\\\\\\\\\\\\\\/XsoMDu9oHi1keFOzPgB9ST2Fv6VE2zWygFa3Mz0zIPWxWpRIoH6z2UZ7MVqfb9khMCQtEZTY1c0EwZ4z4NU8wXoJUGI0oK8VREZzr6D4nIMI8fkQru6ptBV3NF3T1gw\\\\\\\\\\\\\\\/j2w5xwlsu6ZvBCQPuNr\\\\\\\\\\\\\\\/yKAkOXcIEQH\\\\\\\\\\\\\\\/6biwhbv\\\\\\\\\\\\\\\/45TiSKmOH9d6fGMEEKgqFejT3V5zDMoRq1mwDySQ6MACcz9Yj9uv9PG2u7ul9y22NtAeYoDN9t0QIBS6+NnzSmsZJsH+\\\\\\\\\\\\\\\/G0AxeF9vKnyNwl8t5c2NAGPrzppvNo5Udz0\\\\\\\\\\\\\\\/UL1posKHGUfoVP6VqcgkKpz+VrnppMAwoJML\\\\\\\\\\\\\\\/7A+owJf9V5td7i\\\\\\\\\\\\\\\/ai3WDTZawmP\\\\\\\\\\\\\\\/rQKE\\\\\\\\\\\\\\\/xEPu5wV3s5tBRJwRFbCfjK\\\\\\\\\\\\\\\/zKbQOF4vlxzzIgctPUN\\\\\\\\\\\\\\\/mKhlLR7si60vgw7gmcp3+J+RfvvejUxwz+4JS6QES1wc\\\\\\\\\\\\\\\/bBP4JCqXA81Ld6TNI+f1UsKTZZCpPO95lLZZY0UMyvkIA3j2mkTGZdi5KV4BBwybP6DED8hlJz6m807YOkw8CUmBvXu6ObVsRKKdS3us2EOnwm4N4ke2w9R5Cd33W6QF8EadwGxuSLz7mqSWJQdwxvMQCW0mgPnxzSCp9msokIMZ5CBvlBMD+P7EA5KyZZ7Sb1QMxAVQguo3Z5JmCEXUFuZBUQ5SEhzOvgcbFca8X1xcVJ8iSeQmLE27u5gIObdZSe0WnEgekAboYuc15m3YrHYw+8xRE81E6e2ID\\\\\\\\\\\\\\\/xPat6cMnfrKLjqcjsOpUEUpTq+U+Pm6xDkugFiDwR0HypyHE7sWpNCS1XQYigFW8UdWttwo0k3RIcl\\\\\\\\\\\\\\\/+0xqMJq6+za+djSFmGD56LaHj0wlU4PzsPmS3ErQA6wn2w51HT9t4GEawx83CsTC0WFedWpvN1zdVxgptmvEX6njeU0Cv1kVhjic0wI+5BAmzG05WVBHb6aA9sVIru\\\\\\\\\\\\\\\/B\\\\\\\\\\\\\\\/lqrBkQCzQqlv11CsnIAAuxM04xHuFTWT9023dY0sUFvwS6p0K3AEYnJF4R8Di5VBJUAkZR+URe3mHbvJaN8VHSKOj2\\\\\\\\\\\\\\\/OCuSmKxRjWMcpfdy6BsE1z3GVgJ1JmZlE8o2ZB0OhtvqC9UTfvN5Vzic3kT\\\\\\\\\\\\\\\/Tr1leHwgMzYYMPhlq1N2Ksmhw2FMjO7xL\\\\\\\\\\\\\\\/Go6bsDUPZtsAJCkZk8ap1x11ZdR6WFfCMicTW0LfiD5nlNXpP271q9vTXlbYiyMST0c+HqTW+fcTSQifX37\\\\\\\\\\\\\\\/Z347wJMNniBRB1mfKVPzT+VNWtBNOeOGMvFTbM+BNmZZJi6eulrPr8n2xgj0l\\\\\\\\\\\\\\\/jUv8r4J5jFhU96pYPW+sXA1C8uxyzxbkzfYBoJlFcaoZ1MDgylmFFCZrIaJEdvbBGxBVlmSKyjVC1TyyF5Lp+AOVpgBD29y9p5XnlG3hdWk2oAPiOAbmtnaN0QgilsCSvisKaGmWYl\\\\\\\\\\\\\\\/k1mo1ynBhcD\\\\\\\\\\\\\\\/DV3QBoZ0rozlnOJxXAeLO4RenTy9DMo9H\\\\\\\\\\\\\\\/aHXJRAErr26xvSaHRte+uXdD\\\\\\\\\\\\\\\/TDh56M6sDDr3PYhjkgyjDHVrU0nb97i4CdWwTuF5jYBJJl02EJa30NK8ptpL3wIKi+j8+RpyR7uz0LhbAkjqKQDxfWJlIJ7Uqw7yYBNHjzrNQfZR9Un5Q9UaSt25PL9SnmrP4p92p6BvbQlfErI9KJeMHoU5A4s\\\\\\\\\\\\\\\/ZD3JUuFMFZrlkhqYEN4LYevnN5J7fQJ8Y7Dep6qrbIaL99dhgyHc3ahcPaBKW7QJBmNABceG6oyTx49SXi6oEbzGBBsp7vCiSuJEt\\\\\\\\\\\\\\\/J+D\\\\\\\\\\\\\\\/pMY0qbnFLUGF2KsUeB1Jky9llwJ1QHg7xiEy3B4kbO1UsageolIJZKaGLkI=\\\\\\u0022,\\\\\\u0022iv\\\\\\u0022:\\\\\\u0022mOtd6nCnkhnZx5VToJQz7w==\\\\\\u0022,\\\\\\u0022salt\\\\\\u0022:\\\\\\u00223fcf69c0544933648ca27e63b3137e55\\\\\\u0022}\\u0022,\\u0022hmac\\u0022:\\u0022d808b670973867b8349f1ce3bd351d5c3d2d6033a53af3fd1c85db37f270883d\\u0022}\u0022},\u0022highwire\u0022:{\u0022ac\u0022:{\u0022\\\/jitc\\\/7\\\/1\\\/72.atom\u0022:{\u0022access\u0022:{\u0022full\u0022:true,\u0022abstract\u0022:true},\u0022pisa_id\u0022:\u0022\u0022,\u0022apath\u0022:\u0022\\\/jitc\\\/7\\\/1\\\/72.atom\u0022,\u0022jcode\u0022:\u0022jitc\u0022}}},\u0022MutationObserver\u0022:{\u0022js\u0022:\u0022\\\/sites\\\/all\\\/libraries\\\/mutationobserver\\\/MutationObserver.js\u0022},\u0022ajaxPageState\u0022:{\u0022js\u0022:{\u00220\u0022:1,\u0022https:\\\/\\\/d1bxh8uas1mnw7.cloudfront.net\\\/assets\\\/embed.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/highwire\\\/highwire\\\/plugins\\\/content_types\\\/js\\\/highwire_altmetrics.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/contrib\\\/panels_ajax_pane\\\/panels_ajax_pane.js\u0022:1}}});\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Clink type=\u0022text\/css\u0022 rel=\u0022stylesheet\u0022 href=\u0022\/\/www.highwirestage.com\/sites\/default\/files\/advagg_css\/css__dn-cpI1YtkU_iLHgA5WhlkxgYWyat_IxjF_B-WSYrpE__a9hIbt0eaZ7d5nhwnm2weG8R_2eXK4EvoOx9dOxouHE__3qvfz4I9k5oUIeimOjbmdyh6ZgM-xweyVc5gub1_nR4.css\u0022 media=\u0022all\u0022\u003E\u003Clink rel=\u0022stylesheet\u0022 type=\u0022text\/css\u0022 href=\u0022\/sites\/all\/modules\/contrib\/panels\/plugins\/layouts\/onecol\/onecol.css\u0022\u003E\u003C\/head\u003E\u003Cbody\u003E\u003Cdiv class=\u0022panels-ajax-tab-panel panels-ajax-tab-panel-jnl-template-bmjj-tab-art\u0022\u003E\u003Cdiv class=\u0022panel-display panel-1col clearfix\u0022\u003E\n  \u003Cdiv class=\u0022panel-panel panel-col\u0022\u003E\n    \u003Cdiv\u003E\u003Cdiv class=\u0022panel-pane pane-dfp-pane oas-ads oas-ads-mid pull-right\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv id=\u0022dfp-ad-mpu-wrapper\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n\n\u003Cdiv id=\u0022dfp-ad-mpu\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n  \u003Cscript type=\u0022text\/javascript\u0022\u003E\n    googletag.cmd.push(function() {\n      googletag.display(\u0022dfp-ad-mpu\u0022);\n    });\n  \u003C\/script\u003E\u003C\/div\u003E\n\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-1\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003E\u003Ca href=\u0022https:\/\/doi.org\/10.1186\/s40425-019-0541-0\u0022 target=\u0022_new\u0022\u003Ehttps:\/\/doi.org\/10.1186\/s40425-019-0541-0\u003C\/a\u003E\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-altmetrics\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003EStatistics from Altmetric.com\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv data-badge-details=\u0022right\u0022 data-badge-type=\u0022medium-donut\u0022 data-doi=\u002210.1186\/s40425-019-0541-0\u0022 data-hide-no-mentions=\u0022true\u0022 class=\u0022altmetric-embed\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-2 permissions-box\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ERequest Permissions\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003EIf you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center\u0026rsquo;s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-panels-ajax-pane-content permissions-box pane-highwire-permission-link\u0022 id=\u0022request-permissions\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003E\u003Cspan class=\u0022panels-ajax-pane-title\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/span\u003E\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022panels-ajax-pane panels-ajax-pane-new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n  \u003C\/div\u003E\n\u003C\/div\u003E\n\u003C\/div\u003E\u003C\/body\u003E\u003C\/html\u003E\n"}