{"markup":"\u003C!DOCTYPE html PUBLIC \u0022-\/\/W3C\/\/DTD HTML 4.0 Transitional\/\/EN\u0022 \u0022http:\/\/www.w3.org\/TR\/REC-html40\/loose.dtd\u0022\u003E\n\u003C?xml version=\u00221.0\u0022 encoding=\u0022UTF-8\u0022 ?\u003E\u003Chtml version=\u0022HTML+RDFa+MathML 1.1\u0022 content=\u0022http:\/\/purl.org\/rss\/1.0\/modules\/content\/\u0022 dc=\u0022http:\/\/purl.org\/dc\/terms\/\u0022 foaf=\u0022http:\/\/xmlns.com\/foaf\/0.1\/\u0022 og=\u0022http:\/\/ogp.me\/ns#\u0022 rdfs=\u0022http:\/\/www.w3.org\/2000\/01\/rdf-schema#\u0022 sioc=\u0022http:\/\/rdfs.org\/sioc\/ns#\u0022 sioct=\u0022http:\/\/rdfs.org\/sioc\/types#\u0022 skos=\u0022http:\/\/www.w3.org\/2004\/02\/skos\/core#\u0022 xsd=\u0022http:\/\/www.w3.org\/2001\/XMLSchema#\u0022 mml=\u0022http:\/\/www.w3.org\/1998\/Math\/MathML\u0022\u003E\u003Chead\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\ngoogletag.slots[\u0022mpu\u0022] = googletag.defineSlot(\u0022\/21798771943\/JITC-MPU\u0022, [[300, 250], [300, 600], [300, 300], [600, 500]], \u0022dfp-ad-mpu\u0022)\n  .addService(googletag.pubads());\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022https:\/\/d1bxh8uas1mnw7.cloudfront.net\/assets\/embed.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/www.highwirestage.com\/sites\/default\/files\/js\/js_U2pncm4Q4A7IJl4J_deoOoy8h9tU-3gxfOF4iwZdk_g.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\njQuery.extend(Drupal.settings, {\u0022basePath\u0022:\u0022\\\/\u0022,\u0022pathPrefix\u0022:\u0022\u0022,\u0022panels_ajax_pane\u0022:{\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022:\u0022{\\u0022encrypted\\u0022:\\u0022{\\\\\\u0022encrypted\\\\\\u0022:\\\\\\u0022ZAlK1Tj3NAxcUJylS9zgiTCmJk8CILPTDNMUIgP8yfzRZmPc9tQolw2GZ38Sj8RvidkR2MfBTk5lJTfGJl8Dw08t2XYg4APn0UwCtOerQBUGk0xZBIMN+cpyj+Dz9ecEE+sDB3RPOkXR8XDUlCCnRUaG0vG8eSvM3T9ZAZxkUEJqx9rfzsCo2WJYoGQnKge9k8VivF\\\\\\\\\\\\\\\/u0pQwfMM28L\\\\\\\\\\\\\\\/GTrxphqj6qt6ux8dPM8FHF8yD5kiitn4pAndeqZrtERlwyAItZsLK\\\\\\\\\\\\\\\/dXNlw4aEWPNA7YKEFTPd99tOOkwQ968mA7Z9L8lyzKyRVE23c+qFX9BZyEEpBWl+6Ch7sbjMuNxk1twMiIijlk0r7tXCcA+DNdTQmD3\\\\\\\\\\\\\\\/qMKVHJekNfSO\\\\\\\\\\\\\\\/tyg\\\\\\\\\\\\\\\/d60uWsVf+jwJvJK1Or8jeQ5NEbV6npDMIRCk7LpbvHOn3tvFlZAIRmIifin6fqCAyDHvgPntH6TZ6pgohf8JZFodK6QqKtLe78J0ejtSYG6L+RlpB6t5BOhFeNV8\\\\\\\\\\\\\\\/y9m4tT+Err8FW\\\\\\\\\\\\\\\/HhjfuSCb7e4fyusxgq+ugVrvFzckMr2txsD0a6nbC\\\\\\\\\\\\\\\/eVkZn5BK8vUK6Rbj6t15Vy2Qxjldk1kDImxmtQ6KfGKpYJfr37YtaJ7v5rLlIuRdeif+RUefcBp\\\\\\\\\\\\\\\/tj\\\\\\\\\\\\\\\/SgQpWqhre9zBP2J4QhxwxqgHeEIKYvV\\\\\\\\\\\\\\\/kGYXF9rLcWE2lFvpeO04COavL7d7NfY98iAZaHAn+LD4WEf5cmUSvbimYdgtf59goPsT2G9\\\\\\\\\\\\\\\/CC6G6Jy9r18IA\\\\\\\\\\\\\\\/dN+0SpyxrGyhyELDYRwLvh9HQRSaiS6l89Kf18FxOBnKdM9vxquBh+oucr26gQatQDOji6+bpGTuymfX8rEbTdSvWCkuDt8gbUYyFfYtAdmHaifTYyn8IT\\\\\\\\\\\\\\\/VuPfOJ9VoxY0ArSnjrt8ougF3DlvLGT1D+PuM+6rbF7wakKKwRjR3+wYM\\\\\\\\\\\\\\\/pmRv2obkSYdteLq6MwqRh37dtuHtnE3aBcFeFymRUz9SEcPaks3A8EOGZ\\\\\\\\\\\\\\\/VTToAG3C7YhCzew7uCrZibZsMBq5emSTxHXPKiQn0hYHgfpAk\\\\\\\\\\\\\\\/PyRoZYdB8x+AZQhCwnxDc1jmPsKwTfivkN3GNDkQls6rf7KafMg\\\\\\\\\\\\\\\/P3I3V0K2oF5dizu4GnkxhNPLH5NKKTyFeZnGWwy3YvH3DCgk23FWp+Mb\\\\\\\\\\\\\\\/WGiDry\\\\\\\\\\\\\\\/4mw4h4UQr6xNfnPK9OHTJhXGObHDRLuhavuFSrD2XCPr963c6NlWhbX9FJH8RfOkOFHiclu1WozljRKrieghwU3w+GuHz8HW109rcxdy5pqcnXOMmfFstGOB3tgurU6SYFFp9wTNs0e5h17XA7MDsc6AFpAD0nDeCWzvgnPvW23Z0sc7yYbYhdRFtqPIyXgH4aQ4sK5badFL4uKKic4NyZnS5GEnGgMD961xVoKxC4EsO924kc0XtOGkWd0VO\\\\\\\\\\\\\\\/RglQMq6FK5n+bKP0XcacXCKtcSWjydaGgTZRlvTy5p\\\\\\\\\\\\\\\/kzVgoR8HRGmlPRNZVIGevGYqIgAR0krR1Hcpt26CHbHV8jnRkHGGQAT\\\\\\\\\\\\\\\/NL6eA4UDgMk4eN4K1gf+ihQebHW8NLF5zUUYCYSEf3OTTr3usIcyBNwSKeyTZoOtS0XBJGCyWd26jT7UjL5PTmUJEjF534jWtW2blhTc+k727t64rNIAfC9VgdFdFsxHU6SIYBUpCxjhXQS0CJI3MHCj8QOAUenu0LBx0EfmWbxyCM15mg6F9RX0MQs0vCyukkhtcwZizVwMEMASY89NJoFqqe\\\\\\\\\\\\\\\/bTjeEvv9+PaqT2ePn+3CdrmM4sIAimhaH67zRR63dUU1d0twSulkPjr9CTGwCm48hzC3veMUbiG7s8bH6gfP2wnrCKKSQ2nfGluP6T\\\\\\\\\\\\\\\/JvoawvpAMlxHa1+XI1WQMHS\\\\\\\\\\\\\\\/eAb1DMF7RVo5noM\\\\\\\\\\\\\\\/eTbWRqNJ4ZSfQ\\\\\\\\\\\\\\\/jKCiVAuP17C52I21goYB6b4cAS13EfGAALH0KtLwWn5SYWYgGGRRkuhZ1MyRfeuoUUC9MTyvKSCPusXwgIIyz95bQMVCXvyhYvfNxO4T9yoGnNa2Ctxv2WN2D32538K4V6YeFEteIW2SSBrI8vbuSFnCWw0DGWjzN+KR4Z2QwSlm+msbhJljTOaeSe1E+OPz9PjPnbLH5KuhhneUO1VwUiL69dOJ1UrZXb7zUnHKY+Q9MaFWn9j6\\\\\\\\\\\\\\\/Ph7XmbTzXt2JLV7fitg3tRcEt0veBcK0qlrdNagYJnXtAoEQJIO23Bn5WC+jEP9\\\\\\\\\\\\\\\/Jno5mrLKj6hjWjsbkdlmbex04j1ztGMdAA8uhWqu5syWWQhPTczyulwAOsZhExXx\\\\\\\\\\\\\\\/zzuPIMkE9HQl07dVL8pDe4hD6S\\\\\\\\\\\\\\\/LrPLqIDsanCBa6DWhR8aTefG1iMGqdVVgpJ5U33cd5Afim8DRjNH3w6ktHeXhDQIlTfJASv5JHOpjEiwIHH0QahN0dHrzdvMYKXf1x5S2HytOPdabpZVgTsn+777M9hafmkTBYjtsH2u8HPUoP9hbj+mzUOjLL4u\\\\\\\\\\\\\\\/REjKK6jvVEQtep5iB5UuNWJSpWoEp0Bdxl6JzclQiXp1SvxZ5qsoPDRbaBZtPOs1VU23zMe5S8Cw7Jz\\\\\\\\\\\\\\\/7PI3l0fGWc5DTWod8Kh+4Qp7vTicsrOS47UY5IZVutyIIrN6xDynJumx+NdVrm1uUdk=\\\\\\u0022,\\\\\\u0022iv\\\\\\u0022:\\\\\\u0022XxP2wUGzGONOBH3RPmyXzQ==\\\\\\u0022,\\\\\\u0022salt\\\\\\u0022:\\\\\\u00223fcf69c0544933648ca27e63b3137e55\\\\\\u0022}\\u0022,\\u0022hmac\\u0022:\\u002296450c0e742e537dab97db6eb058911ce82dfc8fc96215c830e76a2cf10f580f\\u0022}\u0022},\u0022highwire\u0022:{\u0022ac\u0022:{\u0022\\\/jitc\\\/7\\\/1\\\/164.atom\u0022:{\u0022access\u0022:{\u0022full\u0022:true,\u0022abstract\u0022:true},\u0022pisa_id\u0022:\u0022\u0022,\u0022apath\u0022:\u0022\\\/jitc\\\/7\\\/1\\\/164.atom\u0022,\u0022jcode\u0022:\u0022jitc\u0022}}},\u0022MutationObserver\u0022:{\u0022js\u0022:\u0022\\\/sites\\\/all\\\/libraries\\\/mutationobserver\\\/MutationObserver.js\u0022},\u0022ajaxPageState\u0022:{\u0022js\u0022:{\u00220\u0022:1,\u0022https:\\\/\\\/d1bxh8uas1mnw7.cloudfront.net\\\/assets\\\/embed.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/highwire\\\/highwire\\\/plugins\\\/content_types\\\/js\\\/highwire_altmetrics.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/contrib\\\/panels_ajax_pane\\\/panels_ajax_pane.js\u0022:1}}});\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Clink type=\u0022text\/css\u0022 rel=\u0022stylesheet\u0022 href=\u0022\/\/www.highwirestage.com\/sites\/default\/files\/advagg_css\/css__dn-cpI1YtkU_iLHgA5WhlkxgYWyat_IxjF_B-WSYrpE__a9hIbt0eaZ7d5nhwnm2weG8R_2eXK4EvoOx9dOxouHE__3qvfz4I9k5oUIeimOjbmdyh6ZgM-xweyVc5gub1_nR4.css\u0022 media=\u0022all\u0022\u003E\u003Clink rel=\u0022stylesheet\u0022 type=\u0022text\/css\u0022 href=\u0022\/sites\/all\/modules\/contrib\/panels\/plugins\/layouts\/onecol\/onecol.css\u0022\u003E\u003C\/head\u003E\u003Cbody\u003E\u003Cdiv class=\u0022panels-ajax-tab-panel panels-ajax-tab-panel-jnl-template-bmjj-tab-art\u0022\u003E\u003Cdiv class=\u0022panel-display panel-1col clearfix\u0022\u003E\n  \u003Cdiv class=\u0022panel-panel panel-col\u0022\u003E\n    \u003Cdiv\u003E\u003Cdiv class=\u0022panel-pane pane-dfp-pane oas-ads oas-ads-mid pull-right\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv id=\u0022dfp-ad-mpu-wrapper\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n\n\u003Cdiv id=\u0022dfp-ad-mpu\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n  \u003Cscript type=\u0022text\/javascript\u0022\u003E\n    googletag.cmd.push(function() {\n      googletag.display(\u0022dfp-ad-mpu\u0022);\n    });\n  \u003C\/script\u003E\u003C\/div\u003E\n\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-1\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003E\u003Ca href=\u0022https:\/\/doi.org\/10.1186\/s40425-019-0632-y\u0022 target=\u0022_new\u0022\u003Ehttps:\/\/doi.org\/10.1186\/s40425-019-0632-y\u003C\/a\u003E\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-altmetrics\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003EStatistics from Altmetric.com\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv data-badge-details=\u0022right\u0022 data-badge-type=\u0022medium-donut\u0022 data-doi=\u002210.1186\/s40425-019-0632-y\u0022 data-hide-no-mentions=\u0022true\u0022 class=\u0022altmetric-embed\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-2 permissions-box\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ERequest Permissions\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003EIf you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center\u0026rsquo;s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-panels-ajax-pane-content permissions-box pane-highwire-permission-link\u0022 id=\u0022request-permissions\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003E\u003Cspan class=\u0022panels-ajax-pane-title\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/span\u003E\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022panels-ajax-pane panels-ajax-pane-new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n  \u003C\/div\u003E\n\u003C\/div\u003E\n\u003C\/div\u003E\u003C\/body\u003E\u003C\/html\u003E\n"}