{"markup":"\u003C!DOCTYPE html PUBLIC \u0022-\/\/W3C\/\/DTD HTML 4.0 Transitional\/\/EN\u0022 \u0022http:\/\/www.w3.org\/TR\/REC-html40\/loose.dtd\u0022\u003E\n\u003C?xml version=\u00221.0\u0022 encoding=\u0022UTF-8\u0022 ?\u003E\u003Chtml version=\u0022HTML+RDFa+MathML 1.1\u0022 content=\u0022http:\/\/purl.org\/rss\/1.0\/modules\/content\/\u0022 dc=\u0022http:\/\/purl.org\/dc\/terms\/\u0022 foaf=\u0022http:\/\/xmlns.com\/foaf\/0.1\/\u0022 og=\u0022http:\/\/ogp.me\/ns#\u0022 rdfs=\u0022http:\/\/www.w3.org\/2000\/01\/rdf-schema#\u0022 sioc=\u0022http:\/\/rdfs.org\/sioc\/ns#\u0022 sioct=\u0022http:\/\/rdfs.org\/sioc\/types#\u0022 skos=\u0022http:\/\/www.w3.org\/2004\/02\/skos\/core#\u0022 xsd=\u0022http:\/\/www.w3.org\/2001\/XMLSchema#\u0022 mml=\u0022http:\/\/www.w3.org\/1998\/Math\/MathML\u0022\u003E\u003Chead\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\ngoogletag.slots[\u0022mpu\u0022] = googletag.defineSlot(\u0022\/21798771943\/JITC-MPU\u0022, [[300, 250], [300, 600], [300, 300], [600, 500]], \u0022dfp-ad-mpu\u0022)\n  .addService(googletag.pubads());\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022https:\/\/d1bxh8uas1mnw7.cloudfront.net\/assets\/embed.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/www.highwirestage.com\/sites\/default\/files\/js\/js_U2pncm4Q4A7IJl4J_deoOoy8h9tU-3gxfOF4iwZdk_g.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\njQuery.extend(Drupal.settings, {\u0022basePath\u0022:\u0022\\\/\u0022,\u0022pathPrefix\u0022:\u0022\u0022,\u0022panels_ajax_pane\u0022:{\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022:\u0022{\\u0022encrypted\\u0022:\\u0022{\\\\\\u0022encrypted\\\\\\u0022:\\\\\\u0022VZxe5kkhdJpeuCMRadKHnprdst9vNaHlb4vVCCtzETE75Q7FbfTiU5sERm7SXg7ZhbR5SyZC3RHtGtdY7WKNqCG1tWfjsOgxmwhf5ZXzjQ9b4WtruUM+PWOjL6Bear+Pdj98WwiOmPwVOjzv4o6LiWCmWz1\\\\\\\\\\\\\\\/\\\\\\\\\\\\\\\/DVJOOa32NzTCb7a9t66rchq4LxlhO8keHvlE8JHrL2d2g+O93vGejQsjSw+qEEpc8w9S8C02KgrSziqMsZ9Sof1v0+jT1CoHglSoqETjdaC3IrNkZPknXvzwVgMLPGFpnGGfea5Oud5PtnLCcIxRTcCuyPi2pOnar1oZ4KGpWU8YqIQSI6JGWCBYbSHKmAA9Ce9fNxqVslS4ZSxXU\\\\\\\\\\\\\\\/kyUpNnObHQ8slF4+9tx5FVr8q1k7QqbHAXH9mY0fZCsekBVWM3RxipDeLlTGI6QyE59tCGP1wNerXvuByQcW\\\\\\\\\\\\\\\/v8m03FeMMdniNy+MYq9JeYVD+KygdG3c+9E9Noxd2Q\\\\\\\\\\\\\\\/NuLMxs5FFtnQ1Cs0v4FXKyCR47FfNn9BetwfdOHDnWni6J67V87DRQ5HOe0eB8BfTMrHnEjwkkW8AO2hkmgYYEgsfi1UvwlSrnLhuV4t+UR9awVfATNPwQ2AyCZEO1h2rio1Ghkh75a\\\\\\\\\\\\\\\/NqrtVZsji3OjkGi8kdNof3TUq0TFI2qtiTIiDnVeNMLrr8Tt3fnCnxVfpRt6PATJeigAUmaImrJ7fA8CjtW+rZ3i+1k5Uz8+NzEMGOqnkj1qbWi+oud30OjDOXNYiY8b7wkWgGWLQAbTNtmpeHtlplD8ifYr2he7RQelT9iSfgFxrpRjXur+Rwp8HQrPYnZAckc0DZ6r3Sj7ZFhJhw4y4OEfoDiYA6t6VbB9jKGVTizCYJ5Tes\\\\\\\\\\\\\\\/9cb4SHdtllFUZ8QHCoHEQLuLHstydrDVs4hrJ\\\\\\\\\\\\\\\/\\\\\\\\\\\\\\\/ur0qCuKuE4KbvqU4gnEMhqQ4Bqvk7p4rC5cY8H7QK4DBGNb6aC7xDM8GNfMd9Ov1lVmPIrUrpeOvcyzWfHxTScp2WYqXr76xN\\\\\\\\\\\\\\\/jVuRCn+DqBbeKdITBd6udwuPu5F1ZG5YDlf45KCYTNe72fQeLZ2Vy0Z\\\\\\\\\\\\\\\/J4A00o+bqnixb1nVoLRG10uKswJFj82IluqgCIP3+8Zdfrde2idwF2s8D3B3ddsoN5j7LV88OSmWHdIUeBKX25XAF+kZ2F0mFhxt3CDP4Ve6KX8wqeRxWM8g2Y46R4hS8ypHO26+eVijAYPI8IxkYoXIh\\\\\\\\\\\\\\\/Xh6E33y1XX7dpb60exLiVU5uIqvamxU\\\\\\\\\\\\\\\/MrlmP7Nd7d9P7lbS3WwrTMXslmBbIqJKMlEg8CQF0MucAC2PKsduogKP80tjQabi17DrCC\\\\\\\\\\\\\\\/WE0YlK4CHJrdWD6BMTpWpLmeI4tUE6gIkma6Hk1Bg5nSZAd+l\\\\\\\\\\\\\\\/OHXQYkzIOtqkXhXx3WFoF56XBfcnPQSbDdGeC0jfD4206r21BVyWOIGj64fIxvswx1gv8JM2TCqXO03dQJHlbJ4TaxkVkAYFjnAg6\\\\\\\\\\\\\\\/iqbBJ8mVd6mrbU5hK4xb1XfFmNiub6ziI+lGxRFd\\\\\\\\\\\\\\\/ko3\\\\\\\\\\\\\\\/rSEbkSUByrDabsKpwZ+VjCpvwH3dBKI0qDzjIwlIkrT3s\\\\\\\\\\\\\\\/fkvjC+j9g1fnpE8NjSGzAfSXtLVRZSAycv5mWUIWKz5i7ihtUGk\\\\\\\\\\\\\\\/fVcbVouDA2Caf63imRDCUyvyxDSGP\\\\\\\\\\\\\\\/moY2Q5UXY3zrPE9wwycKQraNUw9+9f4Eu48Zr2Uh54YOP08JHDLhTvHIsE5C7w\\\\\\\\\\\\\\\/f6mkPgJzTKHY0RlqhE3yCivVKF5ru31LOUYJcuM7KMKt9RSourL0hZS+0xbHIoaQckbArz8vP\\\\\\\\\\\\\\\/5HgDLwxGo\\\\\\\\\\\\\\\/IA+XBTvZyjnIPWwWr5oQPMOLFBoq5qC2R4CpXwZ4Tm6r56jwU23q2hIb4uKUOqJ4kxrGPwvfpVrNNaHW+v\\\\\\\\\\\\\\\/bOJ2HcqMfh+rF\\\\\\\\\\\\\\\/ZTm9qOYX+WrJu6imOp+iVUg2C8KONgsjKeO+WIBorfmRbHDFJdoLewzGnShLvPTxCkOurFhYJ2DqokWx4XMpoNJQoZENq+EVadZ3p7PXZ0UKKa5Tw\\\\\\\\\\\\\\\/7xGhlcEejjxtdRYzaSH+YqQ27zZnWtShLiALmKM9ncWb2GrNdTf1ek4CJGV3fDZS9r5A8zr\\\\\\\\\\\\\\\/UOBuXzDY7I5gxRjzeg\\\\\\\\\\\\\\\/hFSEGajdTrQ2xilQ29vmUVNMRdczuJDXmY6Hb45aVshnNClK6inplE3aZUzyh88KCjqfA9a0N9IrOLqvrFsAIdw01AUKE+Xxf7RkBXo3JIfhi98ruT4Im6UoS4KxwGXalBLVDnTWhI\\\\\\\\\\\\\\\/nKDp8eLDIqHns7hyHXJaod540ri7y2bfnnXZ\\\\\\\\\\\\\\\/DKAklv9wcHB9lSdIoTgPaDewdf3YUhkuZZHJulAWpal3MBCUWsXKa5LSGtaAYUKJXQ80bqojAffrNp7trNOZjLcqvf+bSHH+QQ\\\\\\\\\\\\\\\/z9q9fqfq1XGuQ9RFfhAw0hZIZhhovPyqDVP\\\\\\\\\\\\\\\/02WUJmvDhGDNPCT1kQvDD3NLfvW0BJrm3rBL4A8sjEst2HV5+mJ5OZTcJxYcuBnkLnwEwTBbwWM\\\\\\\\\\\\\\\/EiSThXeZqrUVC04YzqdFPm4S0ImRKmX6qEhavl97R40nE5yeZXUoOy0MW4OgGmQ2idqVHNU\\\\\\\\\\\\\\\/7CqJ20aKo2Pao2z4WV+er+uRqwuWef+wZki5\\\\\\\\\\\\\\\/wnGSk=\\\\\\u0022,\\\\\\u0022iv\\\\\\u0022:\\\\\\u002251Q7LwJ0YfBBNiuS+DkM1g==\\\\\\u0022,\\\\\\u0022salt\\\\\\u0022:\\\\\\u00223fcf69c0544933648ca27e63b3137e55\\\\\\u0022}\\u0022,\\u0022hmac\\u0022:\\u00229b01d5dd7b944b9b1f5962867af6c3a87098240abe3370351787f04abd394673\\u0022}\u0022},\u0022highwire\u0022:{\u0022ac\u0022:{\u0022\\\/jitc\\\/7\\\/1\\\/194.atom\u0022:{\u0022access\u0022:{\u0022full\u0022:true,\u0022abstract\u0022:true},\u0022pisa_id\u0022:\u0022\u0022,\u0022apath\u0022:\u0022\\\/jitc\\\/7\\\/1\\\/194.atom\u0022,\u0022jcode\u0022:\u0022jitc\u0022}}},\u0022MutationObserver\u0022:{\u0022js\u0022:\u0022\\\/sites\\\/all\\\/libraries\\\/mutationobserver\\\/MutationObserver.js\u0022},\u0022ajaxPageState\u0022:{\u0022js\u0022:{\u00220\u0022:1,\u0022https:\\\/\\\/d1bxh8uas1mnw7.cloudfront.net\\\/assets\\\/embed.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/highwire\\\/highwire\\\/plugins\\\/content_types\\\/js\\\/highwire_altmetrics.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/contrib\\\/panels_ajax_pane\\\/panels_ajax_pane.js\u0022:1}}});\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Clink type=\u0022text\/css\u0022 rel=\u0022stylesheet\u0022 href=\u0022\/\/www.highwirestage.com\/sites\/default\/files\/advagg_css\/css__dn-cpI1YtkU_iLHgA5WhlkxgYWyat_IxjF_B-WSYrpE__a9hIbt0eaZ7d5nhwnm2weG8R_2eXK4EvoOx9dOxouHE__3qvfz4I9k5oUIeimOjbmdyh6ZgM-xweyVc5gub1_nR4.css\u0022 media=\u0022all\u0022\u003E\u003Clink rel=\u0022stylesheet\u0022 type=\u0022text\/css\u0022 href=\u0022\/sites\/all\/modules\/contrib\/panels\/plugins\/layouts\/onecol\/onecol.css\u0022\u003E\u003C\/head\u003E\u003Cbody\u003E\u003Cdiv class=\u0022panels-ajax-tab-panel panels-ajax-tab-panel-jnl-template-bmjj-tab-art\u0022\u003E\u003Cdiv class=\u0022panel-display panel-1col clearfix\u0022\u003E\n  \u003Cdiv class=\u0022panel-panel panel-col\u0022\u003E\n    \u003Cdiv\u003E\u003Cdiv class=\u0022panel-pane pane-dfp-pane oas-ads oas-ads-mid pull-right\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv id=\u0022dfp-ad-mpu-wrapper\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n\n\u003Cdiv id=\u0022dfp-ad-mpu\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n  \u003Cscript type=\u0022text\/javascript\u0022\u003E\n    googletag.cmd.push(function() {\n      googletag.display(\u0022dfp-ad-mpu\u0022);\n    });\n  \u003C\/script\u003E\u003C\/div\u003E\n\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-1\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003E\u003Ca href=\u0022https:\/\/doi.org\/10.1186\/s40425-019-0675-0\u0022 target=\u0022_new\u0022\u003Ehttps:\/\/doi.org\/10.1186\/s40425-019-0675-0\u003C\/a\u003E\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-altmetrics\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003EStatistics from Altmetric.com\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv data-badge-details=\u0022right\u0022 data-badge-type=\u0022medium-donut\u0022 data-doi=\u002210.1186\/s40425-019-0675-0\u0022 data-hide-no-mentions=\u0022true\u0022 class=\u0022altmetric-embed\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-2 permissions-box\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ERequest Permissions\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003EIf you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center\u0026rsquo;s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-panels-ajax-pane-content permissions-box pane-highwire-permission-link\u0022 id=\u0022request-permissions\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003E\u003Cspan class=\u0022panels-ajax-pane-title\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/span\u003E\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022panels-ajax-pane panels-ajax-pane-new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n  \u003C\/div\u003E\n\u003C\/div\u003E\n\u003C\/div\u003E\u003C\/body\u003E\u003C\/html\u003E\n"}