{"markup":"\u003C!DOCTYPE html PUBLIC \u0022-\/\/W3C\/\/DTD HTML 4.0 Transitional\/\/EN\u0022 \u0022http:\/\/www.w3.org\/TR\/REC-html40\/loose.dtd\u0022\u003E\n\u003C?xml version=\u00221.0\u0022 encoding=\u0022UTF-8\u0022 ?\u003E\u003Chtml version=\u0022HTML+RDFa+MathML 1.1\u0022 content=\u0022http:\/\/purl.org\/rss\/1.0\/modules\/content\/\u0022 dc=\u0022http:\/\/purl.org\/dc\/terms\/\u0022 foaf=\u0022http:\/\/xmlns.com\/foaf\/0.1\/\u0022 og=\u0022http:\/\/ogp.me\/ns#\u0022 rdfs=\u0022http:\/\/www.w3.org\/2000\/01\/rdf-schema#\u0022 sioc=\u0022http:\/\/rdfs.org\/sioc\/ns#\u0022 sioct=\u0022http:\/\/rdfs.org\/sioc\/types#\u0022 skos=\u0022http:\/\/www.w3.org\/2004\/02\/skos\/core#\u0022 xsd=\u0022http:\/\/www.w3.org\/2001\/XMLSchema#\u0022 mml=\u0022http:\/\/www.w3.org\/1998\/Math\/MathML\u0022\u003E\u003Chead\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\ngoogletag.slots[\u0022mpu\u0022] = googletag.defineSlot(\u0022\/21798771943\/JITC-MPU\u0022, [[300, 250], [300, 600], [300, 300], [600, 500]], \u0022dfp-ad-mpu\u0022)\n  .addService(googletag.pubads());\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022https:\/\/d1bxh8uas1mnw7.cloudfront.net\/assets\/embed.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/www.highwirestage.com\/sites\/default\/files\/js\/js_U2pncm4Q4A7IJl4J_deoOoy8h9tU-3gxfOF4iwZdk_g.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\njQuery.extend(Drupal.settings, {\u0022basePath\u0022:\u0022\\\/\u0022,\u0022pathPrefix\u0022:\u0022\u0022,\u0022panels_ajax_pane\u0022:{\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022:\u0022{\\u0022encrypted\\u0022:\\u0022{\\\\\\u0022encrypted\\\\\\u0022:\\\\\\u0022OesILEaC6+x2x\\\\\\\\\\\\\\\/0\\\\\\\\\\\\\\\/3B+\\\\\\\\\\\\\\\/1gZRjhBiSLoQRfPUShm6v\\\\\\\\\\\\\\\/+joiE7j3bFp6hpZbr90s+DSln6ogBPefoyfrPeyNaVGx1x31rQYioZvVrIRWVqEz9xxitF5itRBNX0q6Hp2HRmrVQBZ1bVHdyNMPItVXo48usG0ow\\\\\\\\\\\\\\\/XAwXqmPT+DYAVgvm85ep5b2pIdRufunCofimgDs0EPgQXZFVosnwyT+ApKM2yww\\\\\\\\\\\\\\\/zA5l5HO\\\\\\\\\\\\\\\/6f1NLUh\\\\\\\\\\\\\\\/1D28knznnCkk4YMCqUqtuq4GUgTQpU79L3bFvEG0dant\\\\\\\\\\\\\\\/N3H1ywJsZuYBdjMrWeTi5OlH\\\\\\\\\\\\\\\/WEQZnXR9hYvCE7w3FlPNsVMffGp3fjXQHgl8wkDNF5OL+arHAulRrTLUmTqSF\\\\\\\\\\\\\\\/iq5lNwWu6ReMxKNzSsflL9dnKmYCoxvGQ3UzpbotBd4ymXRsZTG2rxn19ohIY1Z9zI+5qAACCHrUrg7AepvVrtcOWodzaMd58rIkRNc2Y\\\\\\\\\\\\\\\/omX73AoJXktqh+vMA6JDJS1+SZENRmob+Ubmqko0UN8qyOcx3Hh3tZ1lA7PQYr8nqutsejzYuZrZxkXRL4IOf2+ath1eRpi6eDE\\\\\\\\\\\\\\\/ZoH51AlG2zifJpjuV2Zion9ZnY8S\\\\\\\\\\\\\\\/o3djNe\\\\\\\\\\\\\\\/6IMbZqCcdLeB8yZBPPI82sEeVwYGvvhA0hb3XIhr2xQEvqL3o+Nv+V76i2e8JAgBriV79UfhRZucEd49SsMvbpvm2mM2\\\\\\\\\\\\\\\/IyMiwWZKFq6dX5svO2q5XEAihfQqNwB5WKiGAjEFd\\\\\\\\\\\\\\\/hBVnv7D5UOvqZ9NGSTP4wQy4ltYDtC56eI54lZO0j1M6sTV4Ij5gqJgGsq1im1ZeXC+zduj7h\\\\\\\\\\\\\\\/knabNqayHANBbneM\\\\\\\\\\\\\\\/bHSNQK8zCjK7CxMLwXXCN\\\\\\\\\\\\\\\/DmysuuLdy6rB3yfZsAWt2G0\\\\\\\\\\\\\\\/yJh9wgreQWzD4sBbcnEc16ScpzxgtaI66uI25DR35tWjOVjvqJ2MYr2UJHzFiw3asj7aIVpsyGMmmfvubR7at68xKHI\\\\\\\\\\\\\\\/xDAaOvwK\\\\\\\\\\\\\\\/vKol1MtMPagsaD1ZgYoAGGSQoeaOVQvWI2RE2cybSvGbla6ImevmZmp\\\\\\\\\\\\\\\/PvPhrJNbCvR6rmCEG\\\\\\\\\\\\\\\/yi8\\\\\\\\\\\\\\\/cP8AMJG84RevlImNIKe6GevCTngx9s9p0ULZHSn6mHC0wGQme6u0mCC24w04TrubsBjXiy51+35n9NjXejmIgtHjZXKjTygTTO6HLDnv+KbgEFZFaOOERhKlTr9k3BT36lKqagxoleDZmojRJ4rPJwBpefNGYpXGCE2z1LEMlECDsYxiE3Ii32SocFGYK6uNLmGtYlUlG0pIrLZgD9U3niOUfKeW0BJNXDnb8zWlGgA2+WQ6GFmaTcrLdnYrlR0ajbKOUFmHCfppyxFc7zozA38Lb0BEEZ\\\\\\\\\\\\\\\/rvc+IUZcnQVpkXYg39rdXzjLlMWf7xOuSIitGO0vli5PAmhbV8JMw3raU4hexP1zG1OA+tm+XzRYV4HaLFm4c4sX3KOGnVydWlJ6eY4W1omiPp+28ttA1NVc1Pos9KBFDwykYiGUokuXQz6WPumdQzOjZc5JitujLGbUy2ePTMAnBd50WZfDnujXGEMmdxHPHSvC2EquVSCZ++D3OdoGoEr7zhVfC+iTaOCMzU5m66ynA0fN2lpFa5C8GMM9XJGSwxlp2c0Y7mEBZKPVNCI2aauHxi6f7JpZSOKvYcWdjXcO9GWTcwGZbWqqmkudiXmLCWwAAru73+9gVMwtBF0BooiOzWaAURw80hojJ3EAgkempGalomT3bPjDupcLEvS4BClW75VznePhuMA5jjego5kn0bqnUNdkEpVVd3ZNfmAyYuBaP4Yd\\\\\\\\\\\\\\\/37ziLXWM7hyUfA4YdWTHHZmpAqs5xBXxk2SpljFwtwqyoTwgsxcH3Pcw3RPwdEHBAByrwZ1Y1h7GflGJmdAlKp0r\\\\\\\\\\\\\\\/fBjFcljbww5Hm69nA0mjYjgJ1zGynmiaFpEpiv\\\\\\\\\\\\\\\/Z45fDXa56+ccxISytLwB0ag8qIOCWVEYYJ5gngTWnDPSL7eJMeRpxjuolHjXKP48aQCXzHYLClXEZLxi3GBKdkbtLADlhwlKy07Z6fggkSq+0hLa+GxB7mBYLLERgoUdb88+++hjz0PT+g+N\\\\\\\\\\\\\\\/T8GpvQ2GhsV7O4yo9vejOcx+QSkNeRHTPSayuD9qAcxFUiZA4VvGFWAMWGol6UqWRm7i++ISkwa\\\\\\\\\\\\\\\/j663qvE\\\\\\\\\\\\\\\/pifwMfbR8EQCMkXeS5zGHtfHCvuBvRM0w9eMvH3SVPKHVP+VVEh2e2MaEAx7o\\\\\\\\\\\\\\\/fbPOgylICxrfg4oietXTUL5cOgXGaGk5nImh9daRl0DCoPhwHsCDkMHhU8e0irtFmX2vlc3jGEcWFs\\\\\\\\\\\\\\\/j2\\\\\\\\\\\\\\\/FWXb2u1WqUhv+n3Q5Bc\\\\\\\\\\\\\\\/ulSHVMY2gV4K3iPBloAPxfyllmD+H5bSk68BPm1SdTYO1f0\\\\\\\\\\\\\\\/5mZ3\\\\\\\\\\\\\\\/ZXQkXZZ8livWOtN+w3FWVa1RG\\\\\\\\\\\\\\\/LOfQhpUi1jCy2koS3UUZH6EuySDUM2iPMoAFs2dof69nrzoV2JQlF12SNxFnkUyRsbe4Wh5\\\\\\\\\\\\\\\/s0ozDfiG5Bmr7bLoqXbmImCzb1qTz3Qq\\\\\\\\\\\\\\\/6escAggc1+PS+Ac0pRIn4ll7Yn+ZDEaiu01b1+6D4KmiBZiATjcsMatcZprtp7z83FTfidbxcWKF3K19B2tTwUDxV5IeSIdAohWnu4UjWljdqZA6k=\\\\\\u0022,\\\\\\u0022iv\\\\\\u0022:\\\\\\u0022kMm9u7nin9iDb3vGy0mKDQ==\\\\\\u0022,\\\\\\u0022salt\\\\\\u0022:\\\\\\u00223fcf69c0544933648ca27e63b3137e55\\\\\\u0022}\\u0022,\\u0022hmac\\u0022:\\u0022da065adfa3fd233cdc70fd948c92ce78bdcccc877e0ad44f6b8d1d057b7eebcf\\u0022}\u0022},\u0022highwire\u0022:{\u0022ac\u0022:{\u0022\\\/jitc\\\/7\\\/1\\\/52.atom\u0022:{\u0022access\u0022:{\u0022full\u0022:true,\u0022abstract\u0022:true},\u0022pisa_id\u0022:\u0022\u0022,\u0022apath\u0022:\u0022\\\/jitc\\\/7\\\/1\\\/52.atom\u0022,\u0022jcode\u0022:\u0022jitc\u0022}}},\u0022MutationObserver\u0022:{\u0022js\u0022:\u0022\\\/sites\\\/all\\\/libraries\\\/mutationobserver\\\/MutationObserver.js\u0022},\u0022ajaxPageState\u0022:{\u0022js\u0022:{\u00220\u0022:1,\u0022https:\\\/\\\/d1bxh8uas1mnw7.cloudfront.net\\\/assets\\\/embed.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/highwire\\\/highwire\\\/plugins\\\/content_types\\\/js\\\/highwire_altmetrics.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/contrib\\\/panels_ajax_pane\\\/panels_ajax_pane.js\u0022:1}}});\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Clink type=\u0022text\/css\u0022 rel=\u0022stylesheet\u0022 href=\u0022\/\/www.highwirestage.com\/sites\/default\/files\/advagg_css\/css__dn-cpI1YtkU_iLHgA5WhlkxgYWyat_IxjF_B-WSYrpE__a9hIbt0eaZ7d5nhwnm2weG8R_2eXK4EvoOx9dOxouHE__3qvfz4I9k5oUIeimOjbmdyh6ZgM-xweyVc5gub1_nR4.css\u0022 media=\u0022all\u0022\u003E\u003Clink rel=\u0022stylesheet\u0022 type=\u0022text\/css\u0022 href=\u0022\/sites\/all\/modules\/contrib\/panels\/plugins\/layouts\/onecol\/onecol.css\u0022\u003E\u003C\/head\u003E\u003Cbody\u003E\u003Cdiv class=\u0022panels-ajax-tab-panel panels-ajax-tab-panel-jnl-template-bmjj-tab-art\u0022\u003E\u003Cdiv class=\u0022panel-display panel-1col clearfix\u0022\u003E\n  \u003Cdiv class=\u0022panel-panel panel-col\u0022\u003E\n    \u003Cdiv\u003E\u003Cdiv class=\u0022panel-pane pane-dfp-pane oas-ads oas-ads-mid pull-right\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv id=\u0022dfp-ad-mpu-wrapper\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n\n\u003Cdiv id=\u0022dfp-ad-mpu\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n  \u003Cscript type=\u0022text\/javascript\u0022\u003E\n    googletag.cmd.push(function() {\n      googletag.display(\u0022dfp-ad-mpu\u0022);\n    });\n  \u003C\/script\u003E\u003C\/div\u003E\n\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-1\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003E\u003Ca href=\u0022https:\/\/doi.org\/10.1186\/s40425-019-0528-x\u0022 target=\u0022_new\u0022\u003Ehttps:\/\/doi.org\/10.1186\/s40425-019-0528-x\u003C\/a\u003E\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-altmetrics\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003EStatistics from Altmetric.com\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv data-badge-details=\u0022right\u0022 data-badge-type=\u0022medium-donut\u0022 data-doi=\u002210.1186\/s40425-019-0528-x\u0022 data-hide-no-mentions=\u0022true\u0022 class=\u0022altmetric-embed\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-2 permissions-box\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ERequest Permissions\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003EIf you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center\u0026rsquo;s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-panels-ajax-pane-content permissions-box pane-highwire-permission-link\u0022 id=\u0022request-permissions\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003E\u003Cspan class=\u0022panels-ajax-pane-title\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/span\u003E\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022panels-ajax-pane panels-ajax-pane-new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n  \u003C\/div\u003E\n\u003C\/div\u003E\n\u003C\/div\u003E\u003C\/body\u003E\u003C\/html\u003E\n"}