{"markup":"\u003C!DOCTYPE html PUBLIC \u0022-\/\/W3C\/\/DTD HTML 4.0 Transitional\/\/EN\u0022 \u0022http:\/\/www.w3.org\/TR\/REC-html40\/loose.dtd\u0022\u003E\n\u003C?xml version=\u00221.0\u0022 encoding=\u0022UTF-8\u0022 ?\u003E\u003Chtml version=\u0022HTML+RDFa+MathML 1.1\u0022 content=\u0022http:\/\/purl.org\/rss\/1.0\/modules\/content\/\u0022 dc=\u0022http:\/\/purl.org\/dc\/terms\/\u0022 foaf=\u0022http:\/\/xmlns.com\/foaf\/0.1\/\u0022 og=\u0022http:\/\/ogp.me\/ns#\u0022 rdfs=\u0022http:\/\/www.w3.org\/2000\/01\/rdf-schema#\u0022 sioc=\u0022http:\/\/rdfs.org\/sioc\/ns#\u0022 sioct=\u0022http:\/\/rdfs.org\/sioc\/types#\u0022 skos=\u0022http:\/\/www.w3.org\/2004\/02\/skos\/core#\u0022 xsd=\u0022http:\/\/www.w3.org\/2001\/XMLSchema#\u0022 mml=\u0022http:\/\/www.w3.org\/1998\/Math\/MathML\u0022\u003E\u003Chead\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\ngoogletag.slots[\u0022mpu\u0022] = googletag.defineSlot(\u0022\/21798771943\/JITC-MPU\u0022, [[300, 250], [300, 600], [300, 300], [600, 500]], \u0022dfp-ad-mpu\u0022)\n  .addService(googletag.pubads());\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022https:\/\/d1bxh8uas1mnw7.cloudfront.net\/assets\/embed.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/www.highwirestage.com\/sites\/default\/files\/js\/js_U2pncm4Q4A7IJl4J_deoOoy8h9tU-3gxfOF4iwZdk_g.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\njQuery.extend(Drupal.settings, {\u0022basePath\u0022:\u0022\\\/\u0022,\u0022pathPrefix\u0022:\u0022\u0022,\u0022panels_ajax_pane\u0022:{\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022:\u0022{\\u0022encrypted\\u0022:\\u0022{\\\\\\u0022encrypted\\\\\\u0022:\\\\\\u0022KmLBMW\\\\\\\\\\\\\\\/Gkm0T9lS+o5tqE6e8sRR6kDaJ2U9dC4Flvt00GAnWwoP9Y1SRCpzSCfwnp8RAEk2gaAM4ZOr\\\\\\\\\\\\\\\/AJ1iauoZ7gvpQ02aqOJXHxs9nwVUvVZykxgmKOS5L\\\\\\\\\\\\\\\/kOn9jI1vhOPkuji5Y4v6iX6tbPHzWsNxCSJfYWd\\\\\\\\\\\\\\\/cq5MCVDDJjBnYmyStfgleMo3MlEFzcEU8jUrIga7l3te0CWdorpR9z6WZLNjeO7zMRKCfeKTCqtBU6Ibe+4PTkWpvjXAl838bfDAMAfmTnwpGP\\\\\\\\\\\\\\\/S3CxXIK79i8vZPTcCaAHzV+WUg+OporUWlY7N2RcCqPGVSZaTYydC7nMLBlk93l7aBjEtQZC0V73TtqDriMF6\\\\\\\\\\\\\\\/NY+gIWsFyqfJsqipRRrhdkO8qyXQwXrt9EgdBqVGl7Dk9dgfV20cYauU1yvgfC076S8yyyfCjqVpV4V7U6labqw35h02E6VVj0W36gDXAw63Q29H+y2oi62zkdJ9W5VCvK\\\\\\\\\\\\\\\/jEwNtvq7K4+\\\\\\\\\\\\\\\/GXtmeNr\\\\\\\\\\\\\\\/t3J4prYeJ6GVfLCpKoZKESx2oQYE4VeHgSubaY+ipWcH+zJ3Fp7\\\\\\\\\\\\\\\/NhuqbmfL5MUVeUry80pJ2aVj7jC8MoNsOjqqVNVrZIC3MlgYAhbEc+aDdP8qqkN+6g+qCKv8frfwab8\\\\\\\\\\\\\\\/XJvOJjAyBP2p+VXuF6a9zs6ES4GeWewJeh6s9pEh8UGNI\\\\\\\\\\\\\\\/It2kKAOUZxaWIvTlUSO\\\\\\\\\\\\\\\/h49K4sG2gyRuSanqZZmVaptRGohrMYwZ0RG3PJE3xqt\\\\\\\\\\\\\\\/ovM0BI8UFivVTqWSaf+jJ7IE73bvHwtRzD7Bwl01kLyFwPCiik4K2oToRwLTxOh\\\\\\\\\\\\\\\/58OkL9EQAbzTiakk0H9PmUnEVgGCm4TC4zXrvy0dTAnH9tteDFlsEYP4Y0sdZ97xnO26HWpihRxIrKkJ6SpQvKp4QhK8AI9+Xnq8uqvq+S3PNx7ubA+W79gw27+jqj2SrjLjeCXh\\\\\\\\\\\\\\\/JGpGcNxDuwC+awc15hiGwJ1gZKbJJ8ZNrYjJR8suBFuh4jF7pZYa5BDS+cnW0yI\\\\\\\\\\\\\\\/nDZA63eVlUwex7zBH8L\\\\\\\\\\\\\\\/vRCAdplMeNkGwVf0joZ85ugxZ4+4oMybCpCaxqiEoCNcvfS0vGMgW5zjpelmiVLAlCsA2k6\\\\\\\\\\\\\\\/LOrAxPMB1C5XRU\\\\\\\\\\\\\\\/XkjfR8S5y3MFdrmPOUAwF8WYqBaTtaWsUHi7M33HWLHohE1E4STX9MY2s1LNm36zSdmt9tX33zUse9HfqEEwqTYVaaZe6NQ6uiw2DBNTkQg8HrFXLxDoybOE\\\\\\\\\\\\\\\/GLbRl\\\\\\\\\\\\\\\/0CMn0gAtk9u6awE6sZ\\\\\\\\\\\\\\\/PvF1GJaVvJiTr+2e2BqwIF2JzL1f1rJtzwGh3TSIuPNZJHMqkpzuWhbeUZ6wjB4YUAFUbgqaTM0q9DWJK\\\\\\\\\\\\\\\/nR5WZdSBWLoNTgNDuWFt8eJ7XVqkTh2tAA3dboELIcuoWytiDvqFKmIx2fUQONbWfnjfH5cY9rMucAbYA0VBg8c0lnjcyO5qrtQEyGs96H5X5okcwNjzvZsgMlvu8ECazdBxomiY81FsYAOvhELLXqg1uZHK24Htjvu29bA68gPWDwm1mmrEaaxFv\\\\\\\\\\\\\\\/W3FuS0ZJfN7v+gXCYlj0N7zw8kC+D\\\\\\\\\\\\\\\/eb2z5PWCQp4aHc5Xy8SOJhkgNuxChDJw3\\\\\\\\\\\\\\\/QH5DiWlWMrcYt8zMX0+Ye2oNOrrXahDd\\\\\\\\\\\\\\\/vmedPT4VjYSM7Dcxp4rvAQGdmfF9EiCfjJTvMbvHQyR3AoMA9Bg7sVdIAeni3G2JqBFx3LW6DrP+sVIlbbxsHyXsGBe9eDj67G28Rqn3wZD2ZWfS9iTzd71HoGOwFqO3iLWmVwmqhHziw0T+bY12MCivuq4t+0goODsc6G1n3j+VudIEEjtbH9U2RihRxnW\\\\\\\\\\\\\\\/G4f7qYfTMeIqNTBige0YHLYAe4\\\\\\\\\\\\\\\/i3vE5G2C4voXxX+ebFoRVenk1IaFWIkhBzqoit\\\\\\\\\\\\\\\/1YeWwYTXAe4jU4e9udKSQ9D+DpdSpvYorKgoRr3Sxd+ouM\\\\\\\\\\\\\\\/L5oFjhUt8yqnwiV4LlCAKoNw7Unv+88dtQqHDSWoJ6mLvdQXrayOEa0FXzhW7yVJJVbe6BgEJ5VDbVAxe1NEwOeoNzcHGJWFs9ks9j9b7852BRIGziLn2qg8Zf4IPH3sn+sxtGOmhd79AMaPUElaXMm8EaxPVhlcvBXyUyDPhO4xNU3PlaKx3GhS0OWUyjBdYldGuz7EBQbMceuHgXOHYq5G+gGCobv+a9rPz4svwxKteltU2XCz2oo5NVvUskiSnFCE10TNhZO3d3JZls+7lLGR0DP4+EcTpSqc5Q+9E\\\\\\\\\\\\\\\/O95fLXj+HU6n+0vuSr3EPjBkgPMMqkCJl3csSqvH9M4liKytW\\\\\\\\\\\\\\\/A5DR1zw76EUHhBcbAthaIwjRaBeYH\\\\\\\\\\\\\\\/uxHlwpZXNg\\\\\\\\\\\\\\\/H6C3ObEK79APCPJZZ1dB1wvCiLUqXAD4W7Q\\\\\\\\\\\\\\\/pq03pTVgjYLGETrBMGgrWdTF8sESy6naQ8vHm9V5zfzXS8JMyxgcdCKeeCSuhAh9NjwrT2kQDbZaOq+JNa8Ib8NLhYyq7laqA4jDdqXALF2ZT3hCE0m+Iymce1YuITqDwSNGWiqYoVR555k+KvPwVik97r72EMgfvIhWESgu8wx7X79HExw1mRyzJlkC7Lf1y44IP1EmlhCzlDRaOVrEo8MGopWk+oeeMfQrJjKe+EY4Qg=\\\\\\u0022,\\\\\\u0022iv\\\\\\u0022:\\\\\\u00222\\\\\\\\\\\\\\\/jmoSJJrc8i\\\\\\\\\\\\\\\/FuYPoeUWw==\\\\\\u0022,\\\\\\u0022salt\\\\\\u0022:\\\\\\u00223fcf69c0544933648ca27e63b3137e55\\\\\\u0022}\\u0022,\\u0022hmac\\u0022:\\u00228f33eb43821a4accd47ee71282d3ce39c80d7bcc308350f4d3ada2a644c7f897\\u0022}\u0022},\u0022highwire\u0022:{\u0022ac\u0022:{\u0022\\\/jitc\\\/6\\\/1\\\/153.atom\u0022:{\u0022access\u0022:{\u0022full\u0022:true,\u0022abstract\u0022:true},\u0022pisa_id\u0022:\u0022\u0022,\u0022apath\u0022:\u0022\\\/jitc\\\/6\\\/1\\\/153.atom\u0022,\u0022jcode\u0022:\u0022jitc\u0022}}},\u0022MutationObserver\u0022:{\u0022js\u0022:\u0022\\\/sites\\\/all\\\/libraries\\\/mutationobserver\\\/MutationObserver.js\u0022},\u0022ajaxPageState\u0022:{\u0022js\u0022:{\u00220\u0022:1,\u0022https:\\\/\\\/d1bxh8uas1mnw7.cloudfront.net\\\/assets\\\/embed.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/highwire\\\/highwire\\\/plugins\\\/content_types\\\/js\\\/highwire_altmetrics.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/contrib\\\/panels_ajax_pane\\\/panels_ajax_pane.js\u0022:1}}});\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Clink type=\u0022text\/css\u0022 rel=\u0022stylesheet\u0022 href=\u0022\/\/www.highwirestage.com\/sites\/default\/files\/advagg_css\/css__dn-cpI1YtkU_iLHgA5WhlkxgYWyat_IxjF_B-WSYrpE__a9hIbt0eaZ7d5nhwnm2weG8R_2eXK4EvoOx9dOxouHE__3qvfz4I9k5oUIeimOjbmdyh6ZgM-xweyVc5gub1_nR4.css\u0022 media=\u0022all\u0022\u003E\u003Clink rel=\u0022stylesheet\u0022 type=\u0022text\/css\u0022 href=\u0022\/sites\/all\/modules\/contrib\/panels\/plugins\/layouts\/onecol\/onecol.css\u0022\u003E\u003C\/head\u003E\u003Cbody\u003E\u003Cdiv class=\u0022panels-ajax-tab-panel panels-ajax-tab-panel-jnl-template-bmjj-tab-art\u0022\u003E\u003Cdiv class=\u0022panel-display panel-1col clearfix\u0022\u003E\n  \u003Cdiv class=\u0022panel-panel panel-col\u0022\u003E\n    \u003Cdiv\u003E\u003Cdiv class=\u0022panel-pane pane-dfp-pane oas-ads oas-ads-mid pull-right\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv id=\u0022dfp-ad-mpu-wrapper\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n\n\u003Cdiv id=\u0022dfp-ad-mpu\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n  \u003Cscript type=\u0022text\/javascript\u0022\u003E\n    googletag.cmd.push(function() {\n      googletag.display(\u0022dfp-ad-mpu\u0022);\n    });\n  \u003C\/script\u003E\u003C\/div\u003E\n\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-1\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003E\u003Ca href=\u0022https:\/\/doi.org\/10.1186\/s40425-018-0471-2\u0022 target=\u0022_new\u0022\u003Ehttps:\/\/doi.org\/10.1186\/s40425-018-0471-2\u003C\/a\u003E\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-altmetrics\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003EStatistics from Altmetric.com\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv data-badge-details=\u0022right\u0022 data-badge-type=\u0022medium-donut\u0022 data-doi=\u002210.1186\/s40425-018-0471-2\u0022 data-hide-no-mentions=\u0022true\u0022 class=\u0022altmetric-embed\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-2 permissions-box\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ERequest Permissions\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003EIf you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center\u0026rsquo;s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-panels-ajax-pane-content permissions-box pane-highwire-permission-link\u0022 id=\u0022request-permissions\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003E\u003Cspan class=\u0022panels-ajax-pane-title\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/span\u003E\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022panels-ajax-pane panels-ajax-pane-new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n  \u003C\/div\u003E\n\u003C\/div\u003E\n\u003C\/div\u003E\u003C\/body\u003E\u003C\/html\u003E\n"}