{"markup":"\u003C!DOCTYPE html PUBLIC \u0022-\/\/W3C\/\/DTD HTML 4.0 Transitional\/\/EN\u0022 \u0022http:\/\/www.w3.org\/TR\/REC-html40\/loose.dtd\u0022\u003E\n\u003C?xml version=\u00221.0\u0022 encoding=\u0022UTF-8\u0022 ?\u003E\u003Chtml version=\u0022HTML+RDFa+MathML 1.1\u0022 content=\u0022http:\/\/purl.org\/rss\/1.0\/modules\/content\/\u0022 dc=\u0022http:\/\/purl.org\/dc\/terms\/\u0022 foaf=\u0022http:\/\/xmlns.com\/foaf\/0.1\/\u0022 og=\u0022http:\/\/ogp.me\/ns#\u0022 rdfs=\u0022http:\/\/www.w3.org\/2000\/01\/rdf-schema#\u0022 sioc=\u0022http:\/\/rdfs.org\/sioc\/ns#\u0022 sioct=\u0022http:\/\/rdfs.org\/sioc\/types#\u0022 skos=\u0022http:\/\/www.w3.org\/2004\/02\/skos\/core#\u0022 xsd=\u0022http:\/\/www.w3.org\/2001\/XMLSchema#\u0022 mml=\u0022http:\/\/www.w3.org\/1998\/Math\/MathML\u0022\u003E\u003Chead\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\ngoogletag.slots[\u0022mpu\u0022] = googletag.defineSlot(\u0022\/21798771943\/JITC-MPU\u0022, [[300, 250], [300, 600], [300, 300], [600, 500]], \u0022dfp-ad-mpu\u0022)\n  .addService(googletag.pubads());\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022https:\/\/d1bxh8uas1mnw7.cloudfront.net\/assets\/embed.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/www.highwirestage.com\/sites\/default\/files\/js\/js_U2pncm4Q4A7IJl4J_deoOoy8h9tU-3gxfOF4iwZdk_g.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\njQuery.extend(Drupal.settings, {\u0022basePath\u0022:\u0022\\\/\u0022,\u0022pathPrefix\u0022:\u0022\u0022,\u0022panels_ajax_pane\u0022:{\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022:\u0022{\\u0022encrypted\\u0022:\\u0022{\\\\\\u0022encrypted\\\\\\u0022:\\\\\\u0022v47vGJ+qOHH3tguzJ6vAAteVe3qN1KJIKrUd8M3Z6ptne+\\\\\\\\\\\\\\\/bMmTD0rkMx2StUkdfOIxOVXvp9LH5NaYSxcuc4pPdhpHlUn9oSWPy7MWm6EjWF3W9gAlMO4Kfnhd79pWNoXXJ5lCT8iE4evS64PAFknfCu\\\\\\\\\\\\\\\/lXQHFJOEkifOpIzuMOfrk1J8n9Lobx8fffL\\\\\\\\\\\\\\\/L46SRBQDVt\\\\\\\\\\\\\\\/+IzoupVAy8\\\\\\\\\\\\\\\/ayo3qglevSwXpPuRjl3Hhn+h68uSAtt4pclvJV00CZ233rxxG26kHF13XJDatHUthnO2SnlNFLfLyyRdixSon\\\\\\\\\\\\\\\/ijJWVwQ4aA2K4rETuiwQuz7A1iG9\\\\\\\\\\\\\\\/t\\\\\\\\\\\\\\\/2mzPKNqT5RzIGtOCS23uC2sTXBvpnOQI9yqp1ijDkXD8I\\\\\\\\\\\\\\\/+fQUrQLXH35v7xA6NNuAlOoDmm5pOgFqFeMINW7fyg0StGchhpVrIEqjRiQnrrkXlek7oq91Pw1yzYeV6wNafqNaLKkNmdK8N63BFGZT51I8OGx89Vb0rWan6aH7tHyXiupNYC6IYrzSgPaiTNQ7jIMds9jr0SCPNQKKUnmDOZU0zpPSxXFHjYp2rsQe1cjYpQHlBRjhTYuSPoYMgENPj1XjWKCu\\\\\\\\\\\\\\\/Jve3vFKTZBeQjTbV8IUV223PqGiv0WBQOOsDn2VxV6AcqUunsZ\\\\\\\\\\\\\\\/ylSoWAIrxSsderw1\\\\\\\\\\\\\\\/MuPz4YA5ZJu2oZkxYOAwuMdrNMsA6pxYYWU6zaUn1b\\\\\\\\\\\\\\\/2RCLaIx7G3Jdgl9YPzqUdBSkA8Asd7sEX5pccPs\\\\\\\\\\\\\\\/6cHczUZLmmqve9ffLLbJR\\\\\\\\\\\\\\\/BpLuu3GXiRkgYQrhqJfzwr3M2STWGCiIzk\\\\\\\\\\\\\\\/MAA\\\\\\\\\\\\\\\/BUSuauZgFed7arj\\\\\\\\\\\\\\\/VQ6HbY6gQgjJzYysJRxrrgEzmcEaW2TM75a\\\\\\\\\\\\\\\/1Un5XvADuHn92r89ACcLP3SPCeXjMLcA4t9N7jc9SXDkQ10h+GjFDDmUaO8z56cBTLECGkad3A\\\\\\\\\\\\\\\/P+ISZCvczDpm\\\\\\\\\\\\\\\/gBGaCRlqKu4eK\\\\\\\\\\\\\\\/PRffIoQncAvGQBpPTHHmJvKWf5lgZ1Eon6orRdjEVuBUmwYRlG6Lh6UvnW7xfb2JsfYUtztXkf+CRZizUW0dphPBGPuLOzmdOzgoN79aZU3P4pkw00uzjXFVXockcuGrvDI+pOME5swY\\\\\\\\\\\\\\\/zkoByjVTxLGqn2K8V+mK4FiUanBSRyXAf+OWcevWoNADvcFHRNRxfMN790f7JLUJg935r9bu0\\\\\\\\\\\\\\\/M1Ou4\\\\\\\\\\\\\\\/9BvEgdGkFp9lN+CYyB3CIhd6PDhLaZiKBjR4M5xwSCXR1Bd3Yc9kgUp+epFDG+24U3+AMfzy3Y8laRN\\\\\\\\\\\\\\\/SwtTQk6mNMJXbJ\\\\\\\\\\\\\\\/nwMQq1DsIsKS1mk\\\\\\\\\\\\\\\/HqTaUB5FJhaEWjgKg1WTR04MaPI5FgRlOjp93v94YZ9Tx2trzq9jIUMZ6Kb\\\\\\\\\\\\\\\/Tvcc638iEzHrc24cmGfX9z5mMnWYbDeUUjU6d6JKosAwD2wt5nZmfR3NwjthnIxf0xB+XH+EzxS\\\\\\\\\\\\\\\/la+iZIF8qw7aDUUzDF37mCIgc1PdABNbJPcQL+\\\\\\\\\\\\\\\/bcOshwdbu8hY+rKEH32vjLzZJnOXF0dZvxYb4WtzZWTCVyBuUlAlqFM848yg9V6AyqARwsJ5A9ld0WUMp1DoeFZPt\\\\\\\\\\\\\\\/ypBG7EsU04lEqermw80bOY\\\\\\\\\\\\\\\/I4kkO2w7Bzyht73D2eRJ+f6y6z17bubDZxG2PGN287EFWrJsM1DGMT+YUuWZhCdkCVwfyZFS6OHpEdsfHygSQM+ZQIdr7Yry0jFJVFA7VUtsMF9jDTjovbBg1y2oNNN4fCJNTQprwgfWAuDmkk+cmPXPL1hx9IEI7OHvfAA0kCsSnwVFicNJs42F3+nPRFAKcUDDsVW\\\\\\\\\\\\\\\/AselGYC2i3mzbzwLohb54LBY0c4ue5IIgAAb6BGRTJXN5+qbWbXSpkbq5s9n7BczQWYji78GSUK3hpFldW2AhJRyRsX3p9BTEWa3eY4kExN4rqi76HBkvXXGodlciK3AazPiQ7hgVbE\\\\\\\\\\\\\\\/L3x60OLzD5a1Of3Hpw6WX8vzswgM5CQyYJE9gFA1Pgq0kOz5qdcrRPhR3FK+WBtP82jI3xIvFtsQ8G4gr0kC8p3azxFnhhAbV0TZJt7uni4LbP1wXhDH7D8CkYwqEC9RbYs4LdBEnDOVCHmWx4iMZgxhdPW2Dz9LvY0G09WFmdJJ8Z7Icx1IAxgwlWxX3gN9kHkZ9xuWDRKwofPISCLC6qcoE\\\\\\\\\\\\\\\/90us7wf9U7jsy\\\\\\\\\\\\\\\/+6YymD+cojJD36nlAHtZk62XwOTVCDCclwHy8OA0cXpN68TSEjY2MA7ekBjwIQAZUF7NkrGem91VeHdtabn1PEUQTo8h15ENM1jrFZEWVhipQFSsbeRnikUi43iy4HhhH9CjFgiNSAu2C+84Wdeq1fj\\\\\\\\\\\\\\\/q\\\\\\\\\\\\\\\/rp66o2L4s4Rc+RULtC4Ni\\\\\\\\\\\\\\\/eJPEim7T78sYgCydMIoqVSZrKrW3bL5RgThjKtbqpIxrOdfsJ0dB5Fonu5tDYVEs9RJjQ\\\\\\\\\\\\\\\/wxitwYJeDejTrMEFGWwr1QXveRJvSyQDwyF3HrhlAc6OavRG4QqeUdG7q1xqu1iNXbmB6kYiYE8dOT0t6l8GQ54XHuZRbedV8tYP6iNdONnq7O6LkpWFbQHklX3BlUVR9bfwi6w4cv8Z5lWllnMjpGBeX+HX9Pnnr6K48UnGJWFuMTLWSS0czgGBelz2oWw05wEs8wzxQ6U=\\\\\\u0022,\\\\\\u0022iv\\\\\\u0022:\\\\\\u0022l0\\\\\\\\\\\\\\\/rDFb4rlDAWWEWisYhuw==\\\\\\u0022,\\\\\\u0022salt\\\\\\u0022:\\\\\\u00223fcf69c0544933648ca27e63b3137e55\\\\\\u0022}\\u0022,\\u0022hmac\\u0022:\\u0022a681fcb2c87708eafa3641fb2ee251d58d5435c78023d876d0d4bc895e11c3a3\\u0022}\u0022},\u0022highwire\u0022:{\u0022ac\u0022:{\u0022\\\/jitc\\\/6\\\/1\\\/31.atom\u0022:{\u0022access\u0022:{\u0022full\u0022:true,\u0022abstract\u0022:true},\u0022pisa_id\u0022:\u0022\u0022,\u0022apath\u0022:\u0022\\\/jitc\\\/6\\\/1\\\/31.atom\u0022,\u0022jcode\u0022:\u0022jitc\u0022}}},\u0022MutationObserver\u0022:{\u0022js\u0022:\u0022\\\/sites\\\/all\\\/libraries\\\/mutationobserver\\\/MutationObserver.js\u0022},\u0022ajaxPageState\u0022:{\u0022js\u0022:{\u00220\u0022:1,\u0022https:\\\/\\\/d1bxh8uas1mnw7.cloudfront.net\\\/assets\\\/embed.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/highwire\\\/highwire\\\/plugins\\\/content_types\\\/js\\\/highwire_altmetrics.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/contrib\\\/panels_ajax_pane\\\/panels_ajax_pane.js\u0022:1}}});\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Clink type=\u0022text\/css\u0022 rel=\u0022stylesheet\u0022 href=\u0022\/\/www.highwirestage.com\/sites\/default\/files\/advagg_css\/css__dn-cpI1YtkU_iLHgA5WhlkxgYWyat_IxjF_B-WSYrpE__a9hIbt0eaZ7d5nhwnm2weG8R_2eXK4EvoOx9dOxouHE__3qvfz4I9k5oUIeimOjbmdyh6ZgM-xweyVc5gub1_nR4.css\u0022 media=\u0022all\u0022\u003E\u003Clink rel=\u0022stylesheet\u0022 type=\u0022text\/css\u0022 href=\u0022\/sites\/all\/modules\/contrib\/panels\/plugins\/layouts\/onecol\/onecol.css\u0022\u003E\u003C\/head\u003E\u003Cbody\u003E\u003Cdiv class=\u0022panels-ajax-tab-panel panels-ajax-tab-panel-jnl-template-bmjj-tab-art\u0022\u003E\u003Cdiv class=\u0022panel-display panel-1col clearfix\u0022\u003E\n  \u003Cdiv class=\u0022panel-panel panel-col\u0022\u003E\n    \u003Cdiv\u003E\u003Cdiv class=\u0022panel-pane pane-dfp-pane oas-ads oas-ads-mid pull-right\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv id=\u0022dfp-ad-mpu-wrapper\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n\n\u003Cdiv id=\u0022dfp-ad-mpu\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n  \u003Cscript type=\u0022text\/javascript\u0022\u003E\n    googletag.cmd.push(function() {\n      googletag.display(\u0022dfp-ad-mpu\u0022);\n    });\n  \u003C\/script\u003E\u003C\/div\u003E\n\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-1\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003E\u003Ca href=\u0022https:\/\/doi.org\/10.1186\/s40425-018-0329-7\u0022 target=\u0022_new\u0022\u003Ehttps:\/\/doi.org\/10.1186\/s40425-018-0329-7\u003C\/a\u003E\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-altmetrics\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003EStatistics from Altmetric.com\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv data-badge-details=\u0022right\u0022 data-badge-type=\u0022medium-donut\u0022 data-doi=\u002210.1186\/s40425-018-0329-7\u0022 data-hide-no-mentions=\u0022true\u0022 class=\u0022altmetric-embed\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-2 permissions-box\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ERequest Permissions\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003EIf you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center\u0026rsquo;s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-panels-ajax-pane-content permissions-box pane-highwire-permission-link\u0022 id=\u0022request-permissions\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003E\u003Cspan class=\u0022panels-ajax-pane-title\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/span\u003E\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022panels-ajax-pane panels-ajax-pane-new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n  \u003C\/div\u003E\n\u003C\/div\u003E\n\u003C\/div\u003E\u003C\/body\u003E\u003C\/html\u003E\n"}