{"markup":"\u003C!DOCTYPE html PUBLIC \u0022-\/\/W3C\/\/DTD HTML 4.0 Transitional\/\/EN\u0022 \u0022http:\/\/www.w3.org\/TR\/REC-html40\/loose.dtd\u0022\u003E\n\u003C?xml version=\u00221.0\u0022 encoding=\u0022UTF-8\u0022 ?\u003E\u003Chtml version=\u0022HTML+RDFa+MathML 1.1\u0022 content=\u0022http:\/\/purl.org\/rss\/1.0\/modules\/content\/\u0022 dc=\u0022http:\/\/purl.org\/dc\/terms\/\u0022 foaf=\u0022http:\/\/xmlns.com\/foaf\/0.1\/\u0022 og=\u0022http:\/\/ogp.me\/ns#\u0022 rdfs=\u0022http:\/\/www.w3.org\/2000\/01\/rdf-schema#\u0022 sioc=\u0022http:\/\/rdfs.org\/sioc\/ns#\u0022 sioct=\u0022http:\/\/rdfs.org\/sioc\/types#\u0022 skos=\u0022http:\/\/www.w3.org\/2004\/02\/skos\/core#\u0022 xsd=\u0022http:\/\/www.w3.org\/2001\/XMLSchema#\u0022 mml=\u0022http:\/\/www.w3.org\/1998\/Math\/MathML\u0022\u003E\u003Chead\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\ngoogletag.slots[\u0022mpu\u0022] = googletag.defineSlot(\u0022\/21798771943\/JITC-MPU\u0022, [[300, 250], [300, 600], [300, 300], [600, 500]], \u0022dfp-ad-mpu\u0022)\n  .addService(googletag.pubads());\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022https:\/\/d1bxh8uas1mnw7.cloudfront.net\/assets\/embed.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/www.highwirestage.com\/sites\/default\/files\/js\/js_U2pncm4Q4A7IJl4J_deoOoy8h9tU-3gxfOF4iwZdk_g.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\njQuery.extend(Drupal.settings, {\u0022basePath\u0022:\u0022\\\/\u0022,\u0022pathPrefix\u0022:\u0022\u0022,\u0022panels_ajax_pane\u0022:{\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022:\u0022{\\u0022encrypted\\u0022:\\u0022{\\\\\\u0022encrypted\\\\\\u0022:\\\\\\u0022\\\\\\\\\\\\\\\/rPKDdPW21j8\\\\\\\\\\\\\\\/ukl6nGenaW+FDH7RDjlsdDtc6g+wzlwedM4DxX2iUNNBrSQnhj8gqIYsWxn6TgPCf3BtltRbYymzbcIfrXe\\\\\\\\\\\\\\\/\\\\\\\\\\\\\\\/Ld3D9VecZd6Gy5Te\\\\\\\\\\\\\\\/xcnBIyfgzEFNQM4sqWOVPj4BGhxtxAInHpBxsjXhzpggIh11EmIS+LfFHnPEwqaM\\\\\\\\\\\\\\\/EtqmLqfLnzw8OxlgAI\\\\\\\\\\\\\\\/C2VjK3lN8O13IjhcY7LjeBJvF3GXRUra4MTXUtQVZYou4BfGkqXPH3f1\\\\\\\\\\\\\\\/g\\\\\\\\\\\\\\\/fFN2NqA6d83a0TODmnBjPCEApP2qWYXddMJ\\\\\\\\\\\\\\\/4d5Ktuy1aF7ii0eqqVvrXmPoL8IgVEpXLaM5RV5kt8RerIe+cdRBKmADl+ETCAdU18OiDkTVPczljNNsroa7ixFtRH3vvmHiPOQsFt1vV5RB+5Ymd0\\\\\\\\\\\\\\\/Yoyl5RZIkKJLxlRMSJnjFjyAolj8NARNU9yf07F1L59JONar10rXYYj3a2scvka\\\\\\\\\\\\\\\/A+hbd2CCfZJXk1BMh1hZSFp94z0eRTvx2+FQOZHyLcylF1foFk9h5E9rB7UH7he\\\\\\\\\\\\\\\/t0A+zOcefLj8liSlrB8FO0ciTnFNr73Xv1AWptikNOYGATifJfqhD\\\\\\\\\\\\\\\/4PTLO2jTyuUHvWfLr2IYPTD0XJW54d82dBAxYdNCh3OoZfwf6kj62Tty\\\\\\\\\\\\\\\/91ujK00kn51axfq3yudSHcDmYE5ZHcIFOtemkD5VgSyLrVS8m1NVv9W97igs9y4mZe3Oxc67WF7EJJi1m0A7dkobwrtIvWxtFYVT5ecu2hzEY7iGvE3XV4lfCj9TbWA2jSsGSMKxe7szQrI18I3i\\\\\\\\\\\\\\\/xlJNUSr6yPlBjhvMCcUSiY2WJKmpr+OvDtpcW7S+mmdQ8dkYqlpiUtdEoL36\\\\\\\\\\\\\\\/rnPgngxoqvce8zgNGbnFthSNHkmtWYkiQPXDimDhhhYz7kQL4fVTuq3wGcIdi75wEai2Hb4MtM\\\\\\\\\\\\\\\/gTymdOSL58BAusw6fqR1pjZpjYjSjhatkbdQS\\\\\\\\\\\\\\\/RpIksPFoKKpIF1YWQGVZJ4qGOfByCGTnsReQilCRaZi14+Zb54WG\\\\\\\\\\\\\\\/WHOu3HUoa7MnoD+cVBZZHUsJ6huGYARRRT7bJhkRX2tyxkvoyba7u7zfWTDss8yHyQkpyXce1ogK5h\\\\\\\\\\\\\\\/55y1bRk762Sx6ros9qMRR+OWQs2ePciJ39cFDlzR9i0fQ5xtelpOuFbPej6gigqBq48KT8gzQTefupN0zHfYX+xVF60HBvMg6gRDoW7mlZTAAv5BqoAutg6f6X+F8vGqZU7\\\\\\\\\\\\\\\/U7RRVmSxubPkokhVH4tsKSkYVNImN5HbC8ekJ+yfqHhIGRArMc49uw6YEyLBihxO1bQXBC6TG9ZDrqOnHP4KSagRDwNV3mGmL\\\\\\\\\\\\\\\/U+t0gGMoEHKbXwJEjRVtjrRpM1hoO50jztrnN23WRlKelepTRF6g93Br4WczEMbWU7H2HsUNGL7sbfscHNTK+PdIainjMsgV5JD8EEEKuop36PMwL\\\\\\\\\\\\\\\/K\\\\\\\\\\\\\\\/CViB\\\\\\\\\\\\\\\/HtEmBsP6\\\\\\\\\\\\\\\/O+ID229ZdmMEql4BR2R1xFpDhcbTq47pzUY2GVFNrA\\\\\\\\\\\\\\\/M2lL0dsL2bIKAqsGNkoRFlLJkFGxFCYbR4EEpUwHOgH4DegVz1tNjBugsMFZLIc0s81zb8ZRalTIc4f8hh\\\\\\\\\\\\\\\/xdjceErL2KUDT3rk1nHqESSc\\\\\\\\\\\\\\\/Gg0ymXrLGyX5YpKhVL2mBL5mfbOiS799SFg3plWTvSUptVX3knOe4YaZ\\\\\\\\\\\\\\\/N6LjoPCEWEj2E3HLHHjGEbguwAtXxlKuOtbH2ADWqlgCio+0BGkQhc6eOpRHEVHYJP2ITN+zmxbVfi7w\\\\\\\\\\\\\\\/9WOOuov5MwiCxHgL+XSSQpB\\\\\\\\\\\\\\\/YF6e3kw3x+h\\\\\\\\\\\\\\\/gk2mJpf\\\\\\\\\\\\\\\/8aIrRuTxbj9p7RCYMjVWH8VfZuR7UxduGQZ1iVvnTlb+MbS6lX3vxFy39+Jp\\\\\\\\\\\\\\\/l9ByiTVJGqndPekQrtpA3GgB4FUVvkA1vSX\\\\\\\\\\\\\\\/o2ZESzs0JY9VDyZcYYurWH2iw7awwiownHHo+9TrfOy4An9vKBoFktUdUkiH3x8lyRHGK\\\\\\\\\\\\\\\/9ZzWiXZh7h5t2hTYgs5+dLW\\\\\\\\\\\\\\\/13cPgcs7wzqKqArQ0z4EAqJj\\\\\\\\\\\\\\\/K02Dn\\\\\\\\\\\\\\\/dgHEukCH68UIDrcrLXlVvmKNuQbLfGiWGIU2UWizA90NlZQy8BjDfFRimsTnxISISgeOKIvVHo0HxDmqm2BIQGSihwDXYZuUYtbH\\\\\\\\\\\\\\\/xdEYva0h2i+p+ChgKN1kXhL7ufuga2e\\\\\\\\\\\\\\\/WBMcqWfXB1nIV5N1u3sM7cezWKnx1LnXdtNIcLQeLq4rqL0k9gvqwNV+yWLnzxpxxPujFUyjvEvil\\\\\\\\\\\\\\\/hZViwZusET0FR\\\\\\\\\\\\\\\/8EOwKqIiU+eES6PSYsbDK0282PHkvjqGD++BSuYMekt\\\\\\\\\\\\\\\/do\\\\\\\\\\\\\\\/bQV7aKssY9h0NZq5B3yRGMgD4ARdHPDKr5pfn0zN72fvb8pufszIgw2m98ELTtbuWmjelKk0KLz0Ano2kNETzYPhnvcR+ODFDTC601P0GU09oN1fNYi8WVm7Q4feBbHEQguUSc\\\\\\\\\\\\\\\/eOUxn0HbR5vuellV8fAS\\\\\\\\\\\\\\\/G+7ekvvR7YzZAKTQx4S9QQaTe00yOlTK\\\\\\\\\\\\\\\/+v2f87P0QbP2WUvC66CZbULkdAHjsHOETQ4IeZ\\\\\\\\\\\\\\\/qinHJQQ6PYjcH0xTj28nKiCCLWB9q7PfQlvQ+TiYm0j0qgNJ5+fgBth0EMeOJlbpt3x\\\\\\\\\\\\\\\/3jBuOZ49SzaykD6C4=\\\\\\u0022,\\\\\\u0022iv\\\\\\u0022:\\\\\\u0022fS347rJAW1PKJeFnkFuROw==\\\\\\u0022,\\\\\\u0022salt\\\\\\u0022:\\\\\\u00223fcf69c0544933648ca27e63b3137e55\\\\\\u0022}\\u0022,\\u0022hmac\\u0022:\\u0022dc6c9aa447bb5f8952f8cac7454879dfffdf36c7a23d6926c3db3df1b93a7773\\u0022}\u0022},\u0022highwire\u0022:{\u0022ac\u0022:{\u0022\\\/jitc\\\/6\\\/1\\\/155.atom\u0022:{\u0022access\u0022:{\u0022full\u0022:true,\u0022abstract\u0022:true},\u0022pisa_id\u0022:\u0022\u0022,\u0022apath\u0022:\u0022\\\/jitc\\\/6\\\/1\\\/155.atom\u0022,\u0022jcode\u0022:\u0022jitc\u0022}}},\u0022MutationObserver\u0022:{\u0022js\u0022:\u0022\\\/sites\\\/all\\\/libraries\\\/mutationobserver\\\/MutationObserver.js\u0022},\u0022ajaxPageState\u0022:{\u0022js\u0022:{\u00220\u0022:1,\u0022https:\\\/\\\/d1bxh8uas1mnw7.cloudfront.net\\\/assets\\\/embed.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/highwire\\\/highwire\\\/plugins\\\/content_types\\\/js\\\/highwire_altmetrics.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/contrib\\\/panels_ajax_pane\\\/panels_ajax_pane.js\u0022:1}}});\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Clink type=\u0022text\/css\u0022 rel=\u0022stylesheet\u0022 href=\u0022\/\/www.highwirestage.com\/sites\/default\/files\/advagg_css\/css__dn-cpI1YtkU_iLHgA5WhlkxgYWyat_IxjF_B-WSYrpE__a9hIbt0eaZ7d5nhwnm2weG8R_2eXK4EvoOx9dOxouHE__3qvfz4I9k5oUIeimOjbmdyh6ZgM-xweyVc5gub1_nR4.css\u0022 media=\u0022all\u0022\u003E\u003Clink rel=\u0022stylesheet\u0022 type=\u0022text\/css\u0022 href=\u0022\/sites\/all\/modules\/contrib\/panels\/plugins\/layouts\/onecol\/onecol.css\u0022\u003E\u003C\/head\u003E\u003Cbody\u003E\u003Cdiv class=\u0022panels-ajax-tab-panel panels-ajax-tab-panel-jnl-template-bmjj-tab-art\u0022\u003E\u003Cdiv class=\u0022panel-display panel-1col clearfix\u0022\u003E\n  \u003Cdiv class=\u0022panel-panel panel-col\u0022\u003E\n    \u003Cdiv\u003E\u003Cdiv class=\u0022panel-pane pane-dfp-pane oas-ads oas-ads-mid pull-right\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv id=\u0022dfp-ad-mpu-wrapper\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n\n\u003Cdiv id=\u0022dfp-ad-mpu\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n  \u003Cscript type=\u0022text\/javascript\u0022\u003E\n    googletag.cmd.push(function() {\n      googletag.display(\u0022dfp-ad-mpu\u0022);\n    });\n  \u003C\/script\u003E\u003C\/div\u003E\n\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-1\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003E\u003Ca href=\u0022https:\/\/doi.org\/10.1186\/s40425-018-0477-9\u0022 target=\u0022_new\u0022\u003Ehttps:\/\/doi.org\/10.1186\/s40425-018-0477-9\u003C\/a\u003E\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-altmetrics\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003EStatistics from Altmetric.com\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv data-badge-details=\u0022right\u0022 data-badge-type=\u0022medium-donut\u0022 data-doi=\u002210.1186\/s40425-018-0477-9\u0022 data-hide-no-mentions=\u0022true\u0022 class=\u0022altmetric-embed\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-2 permissions-box\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ERequest Permissions\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003EIf you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center\u0026rsquo;s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-panels-ajax-pane-content permissions-box pane-highwire-permission-link\u0022 id=\u0022request-permissions\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003E\u003Cspan class=\u0022panels-ajax-pane-title\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/span\u003E\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022panels-ajax-pane panels-ajax-pane-new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n  \u003C\/div\u003E\n\u003C\/div\u003E\n\u003C\/div\u003E\u003C\/body\u003E\u003C\/html\u003E\n"}