{"markup":"\u003C!DOCTYPE html PUBLIC \u0022-\/\/W3C\/\/DTD HTML 4.0 Transitional\/\/EN\u0022 \u0022http:\/\/www.w3.org\/TR\/REC-html40\/loose.dtd\u0022\u003E\n\u003C?xml version=\u00221.0\u0022 encoding=\u0022UTF-8\u0022 ?\u003E\u003Chtml version=\u0022HTML+RDFa+MathML 1.1\u0022 content=\u0022http:\/\/purl.org\/rss\/1.0\/modules\/content\/\u0022 dc=\u0022http:\/\/purl.org\/dc\/terms\/\u0022 foaf=\u0022http:\/\/xmlns.com\/foaf\/0.1\/\u0022 og=\u0022http:\/\/ogp.me\/ns#\u0022 rdfs=\u0022http:\/\/www.w3.org\/2000\/01\/rdf-schema#\u0022 sioc=\u0022http:\/\/rdfs.org\/sioc\/ns#\u0022 sioct=\u0022http:\/\/rdfs.org\/sioc\/types#\u0022 skos=\u0022http:\/\/www.w3.org\/2004\/02\/skos\/core#\u0022 xsd=\u0022http:\/\/www.w3.org\/2001\/XMLSchema#\u0022 mml=\u0022http:\/\/www.w3.org\/1998\/Math\/MathML\u0022\u003E\u003Chead\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\ngoogletag.slots[\u0022mpu\u0022] = googletag.defineSlot(\u0022\/21798771943\/JITC-MPU\u0022, [[300, 250], [300, 600], [300, 300], [600, 500]], \u0022dfp-ad-mpu\u0022)\n  .addService(googletag.pubads());\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022https:\/\/d1bxh8uas1mnw7.cloudfront.net\/assets\/embed.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/www.highwirestage.com\/sites\/default\/files\/js\/js_U2pncm4Q4A7IJl4J_deoOoy8h9tU-3gxfOF4iwZdk_g.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\njQuery.extend(Drupal.settings, {\u0022basePath\u0022:\u0022\\\/\u0022,\u0022pathPrefix\u0022:\u0022\u0022,\u0022panels_ajax_pane\u0022:{\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022:\u0022{\\u0022encrypted\\u0022:\\u0022{\\\\\\u0022encrypted\\\\\\u0022:\\\\\\u0022kQ9+qNL0O8Ce0KZvptuaQRCdJD01BVAXtINO6tNuvaGb+KB3qS7LVxER8C8cnLMYFMvqNuFPs73ZhQTGxBNLJsYIAo8AG+eSBwJ54mIpw7Q96u2lZa4612S7cBvZXA+DYsmqwWXPBCCEMdznDQFt\\\\\\\\\\\\\\\/Fk+3Y8p8S50+ZWtejMfWYM+Iypddm+IGMcdr6L6zvRkKWcfPIsEjc8DZSnh33O8rDbwgJ1wHE4A8OfMndH7L6rgIewcku6EYPIk006+BRs6WbANfd1IutMz3ctjS1C7G5GzAOf7xsJOKfnx72rvEbBp3G74FWrmalocyitYSZLjkQZGE5c0MEAUJ9logsejbW5IICNYq53CuwV7HG5WEat7ZZpjKDxA3qbdh+k09V\\\\\\\\\\\\\\\/FR+7n+meZWCqPUxGL6uUvx1lnBuG5hpSJhlEw5TZqMkVIpO9GECSuGmE4TQQnH++gW7bMY4lKl2Xfkf5+rgNyTuUwUlyo0Xf+tBLaNXcLbGTNmiXwdsEwhJXqitSPPtQhHCxf9KlZ0PhJdQVJnNTLWrffdO0BE+WyDCHo1pDlSkKiBR1sHee5vVRRbX7jfnxSyI5qt6x5\\\\\\\\\\\\\\\/+tGdo10hkfCseI8Fty2bc\\\\\\\\\\\\\\\/v33ZT\\\\\\\\\\\\\\\/c9OJLfPvP+bUN\\\\\\\\\\\\\\\/j24Nl8uo3N\\\\\\\\\\\\\\\/CV1RqOzn7fuRsibbNsXG1\\\\\\\\\\\\\\\/VOf3QdtQP2MRsgmi3jTA4SItRSR+A7CuMSIjHkZ+L3lWOglC6RFpM1cf4GS\\\\\\\\\\\\\\\/SVcxUoGBE7vpE7js2RWWGjo\\\\\\\\\\\\\\\/FOm8yTPD\\\\\\\\\\\\\\\/UgRGisg1iP0HtkfRMDY5r+QZSv0sTmmQbWIyCXRiEG7B+cThU09e6LV+78+PPYTlE29mH\\\\\\\\\\\\\\\/otZ0IxIOd0MHTMilOrL2i8uk\\\\\\\\\\\\\\\/2ZGE5METSmt3bSGQ\\\\\\\\\\\\\\\/yL3RQ8QjYkp3Vuz4Q8Ts7sLE0QZ04Rup0yv0y\\\\\\\\\\\\\\\/1vTWiV1Q7EG+S3lmjBzsYLkELFSylScH5YBSUvQY64N\\\\\\\\\\\\\\\/X+GCS9sAfzrc4MkDrx5b\\\\\\\\\\\\\\\/sLIhW4RfOr6THST10OT6YcOP3lpSYBgzvFglDSj\\\\\\\\\\\\\\\/hhMXUsd8Ni+6OtezPEYEm7nlpl4chxemf+jmLKeb2VFUcghJbW+VggyMM7bkVhrqcsLRHtl\\\\\\\\\\\\\\\/dmReHKWOHobawPOp5EmFaDFSJ+xs8NDQnfVET8cXtJbbjWoK06rw8BhTkl4JtbYhD+QeIEVjoYRNBEWlaIJ8wd8h7M4XUK7b37jzLOxa9ue7mWT6KuTCPE0cFb\\\\\\\\\\\\\\\/DaR\\\\\\\\\\\\\\\/ghxsgStuTNYlBrS\\\\\\\\\\\\\\\/T5YKtRoD3boSimrBtzLzu3WvrJBz8UOMbFFqhFo\\\\\\\\\\\\\\\/+SG8gr\\\\\\\\\\\\\\\/YG1kvZ589j6vLbws8bs+QpIbZylerY4QbKjw6PT15PTVOxMkX7lcRI8W7rYe45SHS5nVEcF4aTOcUsneScdfC7Pmk0h87iKVr0WzNatJcQTcEcLx+Gg5+hAgu8sEAc6Fl\\\\\\\\\\\\\\\/L12IjobAZJqXNF63YvKn6tDYo2oeg19ksVPP8duvNJQ9AL4VQwF8N8uOsKobf16tMAEhrY2ORnqsDU0ozXA4tphM9WejIgTlka\\\\\\\\\\\\\\\/WtV\\\\\\\\\\\\\\\/f2f66+VITvLtW03bpjClEHxmUZVs4d3GvSOl532ezX\\\\\\\\\\\\\\\/52zLHV6DHlu7kpl\\\\\\\\\\\\\\\/0x4Dp0PrW\\\\\\\\\\\\\\\/SVBqoRNSzd1Cpx1Ugz0CEF1\\\\\\\\\\\\\\\/ibTuzLwsz3ji78\\\\\\\\\\\\\\\/+V3gMW9UoR7OHhzpnXoTNa+aJw67wCKHKTUOCdaD8Y93quuJ2YAgsku7xDyISnUp+AzdEpSwmVOS2izwe+AOXNhKfATptJ1X2cAHCk17DFZv3lOLUoCJTYq1VwLdjwkzfTgmqfnMOAO3JF5z24BD73cRqeRcmsUq6FlQ+9d8dN6fen9f740zGpAQypXB6GSsfAwO7+mDyYcl79Ba9PxbJ7Av97zX7q630FsZ0n8Z2uFNJ8M3\\\\\\\\\\\\\\\/d1qxm4rJ08PV11vJuJerwK4TCl5aJ6jhpjgpcYyZlBn3OYhCMwtSoNd7qG6Bbb2RuFpTi1YOlXr4JUmlX5GxkJfT\\\\\\\\\\\\\\\/5F1eUUESt\\\\\\\\\\\\\\\/pnv\\\\\\\\\\\\\\\/HCX4s2EESfbJMgYaV4MzLGK76PVGMLwiBqAPzVqkGmPIh3hH2pWq6NNGzhPoFy9ciOgwBRmpoTI3Uwiz7bme2mPcWquAwgZz2z\\\\\\\\\\\\\\\/HxYV7P2zN05Tr88kaftD1ksS+eAJcmecTzNHCZJorYCZ+YuKq+DHjBcV+MZLKWO+RJbjzWYNNIJiFdR7WYW2AL3I8r2ChwFGWpVpy\\\\\\\\\\\\\\\/1tqFq6mhr5N1J1oQRO9WkdXAngJproBsDqT5MRSGMykhbvT+w8Ha+bnBmtyN4Jpgti+lzTnMI+pENU82nj9\\\\\\\\\\\\\\\/kJG5H\\\\\\\\\\\\\\\/yasC1Iix1da656lhqTf5ftqzVQ6Qk2+JYhL2SAWw1aOkTwOTbv0bZVXqJBMZXMR6wFcmXyKeeoVsr4kQJAUmoRxo1d86gKGtZOUjLuZKMCHtSSwJjQ1HESl+qxanlViheJmlIVFMp4m6HAyUl8AoBvQ2AW9HqeItvC+OUUjTuXGr1YwTV3m2YpwvZo3qC1Bp6uxqaPZ\\\\\\\\\\\\\\\/52YgdKlWvdytay+fC\\\\\\\\\\\\\\\/E2ZrQcfijAkKtOnzBRrgRVLzlThehbChUCu1xXtmi18p+XRv5BXpGCy8rSdjXuQPf2UYDVdrgigtAg\\\\\\\\\\\\\\\/Hcwb2yRS22HSt8Aj0fep3RyVVkUKbQ\\\\\\\\\\\\\\\/Yd3Hr9tgoV0Ng2lr+6miPuSVwCAEk=\\\\\\u0022,\\\\\\u0022iv\\\\\\u0022:\\\\\\u0022n03Zfhj3MwIQ3lH+jRBLJg==\\\\\\u0022,\\\\\\u0022salt\\\\\\u0022:\\\\\\u00223fcf69c0544933648ca27e63b3137e55\\\\\\u0022}\\u0022,\\u0022hmac\\u0022:\\u0022e396fd5ed5b5c6afe1c29ce5ed5df9d070cf80181df88a318ea0a526434e6d49\\u0022}\u0022},\u0022highwire\u0022:{\u0022ac\u0022:{\u0022\\\/jitc\\\/6\\\/1\\\/26.atom\u0022:{\u0022access\u0022:{\u0022full\u0022:true,\u0022abstract\u0022:true},\u0022pisa_id\u0022:\u0022\u0022,\u0022apath\u0022:\u0022\\\/jitc\\\/6\\\/1\\\/26.atom\u0022,\u0022jcode\u0022:\u0022jitc\u0022}}},\u0022MutationObserver\u0022:{\u0022js\u0022:\u0022\\\/sites\\\/all\\\/libraries\\\/mutationobserver\\\/MutationObserver.js\u0022},\u0022ajaxPageState\u0022:{\u0022js\u0022:{\u00220\u0022:1,\u0022https:\\\/\\\/d1bxh8uas1mnw7.cloudfront.net\\\/assets\\\/embed.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/highwire\\\/highwire\\\/plugins\\\/content_types\\\/js\\\/highwire_altmetrics.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/contrib\\\/panels_ajax_pane\\\/panels_ajax_pane.js\u0022:1}}});\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Clink type=\u0022text\/css\u0022 rel=\u0022stylesheet\u0022 href=\u0022\/\/www.highwirestage.com\/sites\/default\/files\/advagg_css\/css__dn-cpI1YtkU_iLHgA5WhlkxgYWyat_IxjF_B-WSYrpE__a9hIbt0eaZ7d5nhwnm2weG8R_2eXK4EvoOx9dOxouHE__3qvfz4I9k5oUIeimOjbmdyh6ZgM-xweyVc5gub1_nR4.css\u0022 media=\u0022all\u0022\u003E\u003Clink rel=\u0022stylesheet\u0022 type=\u0022text\/css\u0022 href=\u0022\/sites\/all\/modules\/contrib\/panels\/plugins\/layouts\/onecol\/onecol.css\u0022\u003E\u003C\/head\u003E\u003Cbody\u003E\u003Cdiv class=\u0022panels-ajax-tab-panel panels-ajax-tab-panel-jnl-template-bmjj-tab-art\u0022\u003E\u003Cdiv class=\u0022panel-display panel-1col clearfix\u0022\u003E\n  \u003Cdiv class=\u0022panel-panel panel-col\u0022\u003E\n    \u003Cdiv\u003E\u003Cdiv class=\u0022panel-pane pane-dfp-pane oas-ads oas-ads-mid pull-right\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv id=\u0022dfp-ad-mpu-wrapper\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n\n\u003Cdiv id=\u0022dfp-ad-mpu\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n  \u003Cscript type=\u0022text\/javascript\u0022\u003E\n    googletag.cmd.push(function() {\n      googletag.display(\u0022dfp-ad-mpu\u0022);\n    });\n  \u003C\/script\u003E\u003C\/div\u003E\n\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-1\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003E\u003Ca href=\u0022https:\/\/doi.org\/10.1186\/s40425-018-0336-8\u0022 target=\u0022_new\u0022\u003Ehttps:\/\/doi.org\/10.1186\/s40425-018-0336-8\u003C\/a\u003E\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-altmetrics\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003EStatistics from Altmetric.com\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv data-badge-details=\u0022right\u0022 data-badge-type=\u0022medium-donut\u0022 data-doi=\u002210.1186\/s40425-018-0336-8\u0022 data-hide-no-mentions=\u0022true\u0022 class=\u0022altmetric-embed\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-2 permissions-box\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ERequest Permissions\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003EIf you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center\u0026rsquo;s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-panels-ajax-pane-content permissions-box pane-highwire-permission-link\u0022 id=\u0022request-permissions\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003E\u003Cspan class=\u0022panels-ajax-pane-title\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/span\u003E\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022panels-ajax-pane panels-ajax-pane-new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n  \u003C\/div\u003E\n\u003C\/div\u003E\n\u003C\/div\u003E\u003C\/body\u003E\u003C\/html\u003E\n"}