{"markup":"\u003C!DOCTYPE html PUBLIC \u0022-\/\/W3C\/\/DTD HTML 4.0 Transitional\/\/EN\u0022 \u0022http:\/\/www.w3.org\/TR\/REC-html40\/loose.dtd\u0022\u003E\n\u003C?xml version=\u00221.0\u0022 encoding=\u0022UTF-8\u0022 ?\u003E\u003Chtml version=\u0022HTML+RDFa+MathML 1.1\u0022 content=\u0022http:\/\/purl.org\/rss\/1.0\/modules\/content\/\u0022 dc=\u0022http:\/\/purl.org\/dc\/terms\/\u0022 foaf=\u0022http:\/\/xmlns.com\/foaf\/0.1\/\u0022 og=\u0022http:\/\/ogp.me\/ns#\u0022 rdfs=\u0022http:\/\/www.w3.org\/2000\/01\/rdf-schema#\u0022 sioc=\u0022http:\/\/rdfs.org\/sioc\/ns#\u0022 sioct=\u0022http:\/\/rdfs.org\/sioc\/types#\u0022 skos=\u0022http:\/\/www.w3.org\/2004\/02\/skos\/core#\u0022 xsd=\u0022http:\/\/www.w3.org\/2001\/XMLSchema#\u0022 mml=\u0022http:\/\/www.w3.org\/1998\/Math\/MathML\u0022\u003E\u003Chead\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\ngoogletag.slots[\u0022mpu\u0022] = googletag.defineSlot(\u0022\/21798771943\/JITC-MPU\u0022, [[300, 250], [300, 600], [300, 300], [600, 500]], \u0022dfp-ad-mpu\u0022)\n  .addService(googletag.pubads());\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022https:\/\/d1bxh8uas1mnw7.cloudfront.net\/assets\/embed.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/www.highwirestage.com\/sites\/default\/files\/js\/js_U2pncm4Q4A7IJl4J_deoOoy8h9tU-3gxfOF4iwZdk_g.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\njQuery.extend(Drupal.settings, {\u0022basePath\u0022:\u0022\\\/\u0022,\u0022pathPrefix\u0022:\u0022\u0022,\u0022panels_ajax_pane\u0022:{\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022:\u0022{\\u0022encrypted\\u0022:\\u0022{\\\\\\u0022encrypted\\\\\\u0022:\\\\\\u0022u5Uhx0qsuJSbocG9J2FP74bwFfeFBk3t2JBloWRbjIT0B49h\\\\\\\\\\\\\\\/\\\\\\\\\\\\\\\/mZ3XFS6pYjt9oa1llUbfJURiBZOzqWk7fbnYjXIj4QHOx1VMWt0O8rkrxyjIMs5RdEJifzkrxb5PrnUeYEUO0LxdSXpU52nmS16iaFL1+ToFzdvKX+TczNXO6nE6rrwSCzzcHiQLoqP2NwPVSCrg2KurXMGaDdvTucNdfg2LpUSFMQtfyXdXId0ycq7UlZX80V2QWeTeD1tjAQY6mFoMzk0wqEOR20WIs1hB7Jptn52XazsXcEsYUYTphLONN8827zwY9EgSre8kU\\\\\\\\\\\\\\\/X6HMZpdw52OqEQ0oYXX2lxiFdQPYgbgrbHpY5+iLvZ6f7yRrD6zBfLBXSsZGLgOSSM7zEtM\\\\\\\\\\\\\\\/U47+dANXPac6Wu5xDCnBi\\\\\\\\\\\\\\\/e0D3zK2Wi+BB6Ro7J4Vd25h53IYr0R9BEl1IXjWdUYzwlsYoNYmrZQ0QnpLn5UWgG92jMj4EyjMFVPhbBTjdjmcUH4W4YSl8KUV7kidhP3sxHEGNwWGXMfzxnTe7OBOq\\\\\\\\\\\\\\\/xrQOTrfVxJr04u3U6w9JH4LJ5mQ3fdUSiEkjeBCMORDIoMC\\\\\\\\\\\\\\\/zn5IThmOaJFLAbWP1+76r4exDTn6LDMqcUyrVN4ubWVItotxuqLXdmkDV16RGxfnjc2qNmm+rA4T4TftMMdMLp7XjbZfYri1lIYrae\\\\\\\\\\\\\\\/Y+bTVixaewDj\\\\\\\\\\\\\\\/lKevm8EhdBoQxBPa5Dmy4ZB9hpXTdVsV\\\\\\\\\\\\\\\/VUzKR6jQBJ+TJqhG1ye4aFNWFK4uUi\\\\\\\\\\\\\\\/m7uzxXCan6qv7UNSGbext81mnvb5LACaIfNkJZI7NaqJ\\\\\\\\\\\\\\\/EJTCTeloPRhivhOFGXjq8w7+vdfb5QpDCe1lqAJpqE1HpOgyRX9b1S7Wp4Jyi8vTiEnwjNeXlYUpxdgh9Vza2i1bFQo90fOaivlRRSisA4beGh+5che+lOts+dTIOgvLmR3kpM4L+5+2WNMylPoJv\\\\\\\\\\\\\\\/GoVqKZkpNTQf1YNVBG8kET0Txf60N9BfsDekyAvHMRa5bKNwNwIP81mD3zymMBHvLyz1AS36oGYSVw5SqJtOALcUArt1oFdlu6pqEBSi\\\\\\\\\\\\\\\/\\\\\\\\\\\\\\\/xiuVjVo\\\\\\\\\\\\\\\/gMCqYQZMPmZqoziLa4hSGNFcQAEXqS8t3S\\\\\\\\\\\\\\\/Wfv8cYs11wer6sS6AAHX6ftxdaAdGxqW1OHjdGfWJR6KrViNojhYgyVNVtvpqZJyqRh3IYBqLIEZRUgF+2Evg0wluHVbm7P4r2tHpndEWXSpaXWZ7eP8YfZLmQRpVcNExfaV8XG7JTFULIqGXXbq+o7Ii4hNUCLL5sKPaML1V39R2ZNs6EJBXFnNufFDm4arj4ydYPxWqdII6sRB77gZ25qv1uXfpDxFRlgK0cPmNeQi5H4XPQw4ZvLAQlgtI85L\\\\\\\\\\\\\\\/OQp8Y9p4nEXgalYLOijLgIQrimV8M0MbfpeR5+d8UT9vR9PCJCmutkqdj4D3lHzWUUKuzKeg2xF0k9BkQjx73RY+NJoSScz+vOG6cFcZMamSz1IzJnMNdssVH2x1D7AsS2xKgSmsb0BgqzZX6\\\\\\\\\\\\\\\/bUwHIQKDPkQFRfl4FIxyzeSq9FUwu95DFZx+V7s+4MnNBT4JlVMTub356d6NdET13JQhovjFx2B6ZbB\\\\\\\\\\\\\\\/fzN2iQXzrs6J4NLI+UVC7R8jrcldl26\\\\\\\\\\\\\\\/2CFQMmLCG7GjK5CmZDCgUqzDm1834g3LcN8R17\\\\\\\\\\\\\\\/alUE7wx1MeDTyXRTXAV\\\\\\\\\\\\\\\/pOGmI0r0ZJGJ3nD\\\\\\\\\\\\\\\/oq4BaB25K1RI7VBGR5wHeFQ0DBTQ95bjcosiT6l4K4vj65PLWHLXgVdcoDhJYHcFdloENhIU8BuNRaFZm7DsSdsRUTcfIBrlJokWA6ap\\\\\\\\\\\\\\\/2p+aDnj7xVv\\\\\\\\\\\\\\\/WHmAyrIM4uab3oBTPJ20IrHFfbTbKn15Rz0dUH2bt7p5nK5ox95p2pAwzHoQx1JG1AQMyOrg6QNrGZh2ByNWs868b\\\\\\\\\\\\\\\/UT68oc6w7RlItHIE\\\\\\\\\\\\\\\/TOX1Wen5afNbEIWy1GRCDmm46cNKbWlpImESQQLf7yb\\\\\\\\\\\\\\\/oX+SLyLB49njvlLXe+VAyz2yt5FWHq\\\\\\\\\\\\\\\/YCimAkCi0iHuTYhdZIB7zWTWpvcWtYaMOxI1UJQCVEzvpNAX1yRmcyQ8AvRZe8isRBqQzvX4lbeaY\\\\\\\\\\\\\\\/anCvZ8rGSTcShch5Q1sLvddA0HyIn5vVmrc4Gl5wpbMPzcEW5Xtv8aBIGTyo2iFTmF0Y7Z\\\\\\\\\\\\\\\/rVvgOLlPwTCx30hdsX1xb7PUiH5wxqrGuyz6msOI6T2d+ApvCncaXlQt0ItAk2k9AMJuT6ZLCKEYuO6C2lxXdfNY\\\\\\\\\\\\\\\/1UhGiYu6u9oKnSu77sa5XbQActTgoh3F2Fyy+qiEHSUzFubHeL4+tD62vr82nzf2pRLr9LuD1DcE7L32qWiVTwpyG7\\\\\\\\\\\\\\\/lQFz9Y5qauOZPrQ0aQ6jFs3jEYCdRjVSVU2d5fA5L9SKdYFOhjjyZ06kpk2lYCadkFmO\\\\\\\\\\\\\\\/EIS+pmoLccSHuHJI68wIexL+WS6BO7ELn+QE4ZcMwSFVlUHkVZbs9aMS\\\\\\\\\\\\\\\/L01NROZyxtxu8FmEeQ6Bjar7ZSm4x+gM74DACL9Te75JqWCKrQ9MW1ddeTk5UEGKtoWk70d7mqoh7od+urE\\\\\\\\\\\\\\\/nX+NBzmghpS1+rXaK\\\\\\\\\\\\\\\/VBdhwmF5ADNV1NyfXDTBW\\\\\\\\\\\\\\\/58XO4xrohufpMNF2VKHg=\\\\\\u0022,\\\\\\u0022iv\\\\\\u0022:\\\\\\u00227\\\\\\\\\\\\\\\/7nLaPy4ZgLyzRyV+vFNg==\\\\\\u0022,\\\\\\u0022salt\\\\\\u0022:\\\\\\u00223fcf69c0544933648ca27e63b3137e55\\\\\\u0022}\\u0022,\\u0022hmac\\u0022:\\u002293152da0ccfd658a382a716f0af8ddd0aab715696035f98d5b2888cdfcbd1614\\u0022}\u0022},\u0022highwire\u0022:{\u0022ac\u0022:{\u0022\\\/jitc\\\/6\\\/1\\\/25.atom\u0022:{\u0022access\u0022:{\u0022full\u0022:true,\u0022abstract\u0022:true},\u0022pisa_id\u0022:\u0022\u0022,\u0022apath\u0022:\u0022\\\/jitc\\\/6\\\/1\\\/25.atom\u0022,\u0022jcode\u0022:\u0022jitc\u0022}}},\u0022MutationObserver\u0022:{\u0022js\u0022:\u0022\\\/sites\\\/all\\\/libraries\\\/mutationobserver\\\/MutationObserver.js\u0022},\u0022ajaxPageState\u0022:{\u0022js\u0022:{\u00220\u0022:1,\u0022https:\\\/\\\/d1bxh8uas1mnw7.cloudfront.net\\\/assets\\\/embed.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/highwire\\\/highwire\\\/plugins\\\/content_types\\\/js\\\/highwire_altmetrics.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/contrib\\\/panels_ajax_pane\\\/panels_ajax_pane.js\u0022:1}}});\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Clink type=\u0022text\/css\u0022 rel=\u0022stylesheet\u0022 href=\u0022\/\/www.highwirestage.com\/sites\/default\/files\/advagg_css\/css__dn-cpI1YtkU_iLHgA5WhlkxgYWyat_IxjF_B-WSYrpE__a9hIbt0eaZ7d5nhwnm2weG8R_2eXK4EvoOx9dOxouHE__3qvfz4I9k5oUIeimOjbmdyh6ZgM-xweyVc5gub1_nR4.css\u0022 media=\u0022all\u0022\u003E\u003Clink rel=\u0022stylesheet\u0022 type=\u0022text\/css\u0022 href=\u0022\/sites\/all\/modules\/contrib\/panels\/plugins\/layouts\/onecol\/onecol.css\u0022\u003E\u003C\/head\u003E\u003Cbody\u003E\u003Cdiv class=\u0022panels-ajax-tab-panel panels-ajax-tab-panel-jnl-template-bmjj-tab-art\u0022\u003E\u003Cdiv class=\u0022panel-display panel-1col clearfix\u0022\u003E\n  \u003Cdiv class=\u0022panel-panel panel-col\u0022\u003E\n    \u003Cdiv\u003E\u003Cdiv class=\u0022panel-pane pane-dfp-pane oas-ads oas-ads-mid pull-right\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv id=\u0022dfp-ad-mpu-wrapper\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n\n\u003Cdiv id=\u0022dfp-ad-mpu\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n  \u003Cscript type=\u0022text\/javascript\u0022\u003E\n    googletag.cmd.push(function() {\n      googletag.display(\u0022dfp-ad-mpu\u0022);\n    });\n  \u003C\/script\u003E\u003C\/div\u003E\n\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-1\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003E\u003Ca href=\u0022https:\/\/doi.org\/10.1186\/s40425-018-0338-6\u0022 target=\u0022_new\u0022\u003Ehttps:\/\/doi.org\/10.1186\/s40425-018-0338-6\u003C\/a\u003E\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-altmetrics\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003EStatistics from Altmetric.com\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv data-badge-details=\u0022right\u0022 data-badge-type=\u0022medium-donut\u0022 data-doi=\u002210.1186\/s40425-018-0338-6\u0022 data-hide-no-mentions=\u0022true\u0022 class=\u0022altmetric-embed\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-2 permissions-box\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ERequest Permissions\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003EIf you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center\u0026rsquo;s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-panels-ajax-pane-content permissions-box pane-highwire-permission-link\u0022 id=\u0022request-permissions\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003E\u003Cspan class=\u0022panels-ajax-pane-title\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/span\u003E\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022panels-ajax-pane panels-ajax-pane-new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n  \u003C\/div\u003E\n\u003C\/div\u003E\n\u003C\/div\u003E\u003C\/body\u003E\u003C\/html\u003E\n"}