{"markup":"\u003C!DOCTYPE html PUBLIC \u0022-\/\/W3C\/\/DTD HTML 4.0 Transitional\/\/EN\u0022 \u0022http:\/\/www.w3.org\/TR\/REC-html40\/loose.dtd\u0022\u003E\n\u003C?xml version=\u00221.0\u0022 encoding=\u0022UTF-8\u0022 ?\u003E\u003Chtml version=\u0022HTML+RDFa+MathML 1.1\u0022 content=\u0022http:\/\/purl.org\/rss\/1.0\/modules\/content\/\u0022 dc=\u0022http:\/\/purl.org\/dc\/terms\/\u0022 foaf=\u0022http:\/\/xmlns.com\/foaf\/0.1\/\u0022 og=\u0022http:\/\/ogp.me\/ns#\u0022 rdfs=\u0022http:\/\/www.w3.org\/2000\/01\/rdf-schema#\u0022 sioc=\u0022http:\/\/rdfs.org\/sioc\/ns#\u0022 sioct=\u0022http:\/\/rdfs.org\/sioc\/types#\u0022 skos=\u0022http:\/\/www.w3.org\/2004\/02\/skos\/core#\u0022 xsd=\u0022http:\/\/www.w3.org\/2001\/XMLSchema#\u0022 mml=\u0022http:\/\/www.w3.org\/1998\/Math\/MathML\u0022\u003E\u003Chead\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\ngoogletag.slots[\u0022mpu\u0022] = googletag.defineSlot(\u0022\/21798771943\/JITC-MPU\u0022, [[300, 250], [300, 600], [300, 300], [600, 500]], \u0022dfp-ad-mpu\u0022)\n  .addService(googletag.pubads());\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022https:\/\/d1bxh8uas1mnw7.cloudfront.net\/assets\/embed.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/www.highwirestage.com\/sites\/default\/files\/js\/js_U2pncm4Q4A7IJl4J_deoOoy8h9tU-3gxfOF4iwZdk_g.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\njQuery.extend(Drupal.settings, {\u0022basePath\u0022:\u0022\\\/\u0022,\u0022pathPrefix\u0022:\u0022\u0022,\u0022panels_ajax_pane\u0022:{\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022:\u0022{\\u0022encrypted\\u0022:\\u0022{\\\\\\u0022encrypted\\\\\\u0022:\\\\\\u0022o3IJZnjz6VVsboDyCRLKb0L6epofZZH3vPFN87Mx6nfOWmhiif0s+ZiZvKB7sYQwi\\\\\\\\\\\\\\\/GKNpYOvlKQdO2mnhva2QJ9h8sY5SrnsY2kUTcL7wjrUVRQQ4aNqhY9khNsVETVHdiYJ4J1XLypMZs60tKE3qa3kFJs0uGkmHvtihAuCmhjCX0vwFjU+PZDZS5XHh+Funv\\\\\\\\\\\\\\\/tFF1ISH0wMn\\\\\\\\\\\\\\\/J5ff0sdw5Eyevt7Ta\\\\\\\\\\\\\\\/\\\\\\\\\\\\\\\/MLQNMl1+H4AeblU9r16mcPVp+e6ohhrO50fhJrpp8gxn4eASwl4ZBNTzgfsoTOktQPKT3LmcuSOlrqi\\\\\\\\\\\\\\\/umW9ztJstJbv+fZNvG3WMayoyAXBkgTtPoXOUN\\\\\\\\\\\\\\\/9nUB6y\\\\\\\\\\\\\\\/dwDDPMPubmOdjCKpDeMKKbQomvikMCwsv\\\\\\\\\\\\\\\/8YsulxtbkSZUCxhOmxh41tfBtcdxAZ2H2lzrf5mKZ1R0b96irp8+5HvjqMz\\\\\\\\\\\\\\\/DPNXauzuCSVUA5NeGpg7tR8ugHhhWrQVjMdSxS0mocEY3vSquohpkXn8aVNcDlqBkeds4U7fr2S8PMyshabP1ZDgBblg+b4Wcy\\\\\\\\\\\\\\\/1qHeh00ZnKSaPmkrzlLJovpy7VvPxIZLS7ldOeR7DkQK3AINOah6rcnV1o35NW8sjBd9fY6FIO5J6hJHOMf4cwq3Hpgydfawnl5c0QnR\\\\\\\\\\\\\\\/KRa3mGWiROpDbI0h+8U7OdX2OZ6ECKDW4LKJ5ZrJ\\\\\\\\\\\\\\\/pwe\\\\\\\\\\\\\\\/rrHvjwd9WPQwIJ7JVQZTEOy+F6PXOvh\\\\\\\\\\\\\\\/b2ZMvZjvbx5hK5JVjVJM9auB7ni7NQ\\\\\\\\\\\\\\\/Bs2RM8Vun9SGshZUR7OKgCfmCini+ZqpTm4WeMGz2QdvdjKdfac+tAufndhtocIXtrZJfmWadlpQBkD5WhvfJH3YoNK7axD+EiFJLIDeKCDwroixwfIfsoi+drbBA7pmbK2MVAvWCZa5kD5EW3s7dXq9Sf6g2PhJRUp9b9zk5qC\\\\\\\\\\\\\\\/Yd3oRl4fn4rrCMBUVhiRjUao\\\\\\\\\\\\\\\/bsDIsfW4axlQHDH3\\\\\\\\\\\\\\\/sMT1Gyg\\\\\\\\\\\\\\\/zo4rEeyuwr3RmQHhO4FerSPsF5GIcpu4A3S70X3CCgG0U2cgwrVR0oq9nSYBr5Qz1VXuRt7QRX+Pa\\\\\\\\\\\\\\\/SuI+5sVlLoCOP2IjWsyT5Km8RksbR0VSV+tENzlcCCizLHS\\\\\\\\\\\\\\\/aZMS2GYBYMpjq+bNIL6VZmH46Gm7hYr5TkMgvs\\\\\\\\\\\\\\\/++I+16dt1lLbpfDcr5FdmHO1WhsDgfyaOL4HLADy5Sa83WAWDExSaq\\\\\\\\\\\\\\\/E5XWVHlM7q4LRgeUHXJR1dRVvr1ZKc68lQY5gJryJskgxq\\\\\\\\\\\\\\\/HBW8vZrfJnniqEEWsVPf2nfFRozW2b5K8PpQNmMbrnxd\\\\\\\\\\\\\\\/viNtJoAOIlqINzDclJLGK26xf0bOSH+jQ5i0bQwaag80dcas5ooOVo3xLH4lwrd8hlebJzKbzps9IaUAy\\\\\\\\\\\\\\\/dJJiklW2RKQGFWwv3mVu3+NBb\\\\\\\\\\\\\\\/f\\\\\\\\\\\\\\\/jJgZfYFuueF3uZnRvPvcuDVgXXG9Tv0\\\\\\\\\\\\\\\/IlXproYsd74fplUe8A0\\\\\\\\\\\\\\\/VyDuY189wNGFJnx6TMwdOK+EEiCgapXE3ynLlaEPBhJk5EJMmBrqG98m3nmVw58ZglyAks5BqjXNjFhNwumiXj8E6GzNeGWNm+nBho\\\\\\\\\\\\\\\/90p4eEWektJD9erDl0u9qDQR38gKt604b3VxL4iuaXwPP9a\\\\\\\\\\\\\\\/qECj2CaakJ6xdCWkQqDcSjbrq1e78VJ8NjA8uYB1Z8QsiQ9p+v2EPujvEayHExRecum43RH7JI6IXKuAPN3j+Jz+rCrlDYZ\\\\\\\\\\\\\\\/X+Az622cp88qzoEVTkfDF1cnJWwMmNN7FirpQHST\\\\\\\\\\\\\\\/fMnwiyFvuZZBH\\\\\\\\\\\\\\\/loyF3XV3w4H\\\\\\\\\\\\\\\/MxIyEJGeYlcUvPda8ENN1fdROAHjmuFX0cbqVtmJxUr7KQBWQh\\\\\\\\\\\\\\\/EkrZc4UzSQK3Sa1t9MHgpwsTdAifsIDZFYiKi8pnBvk9\\\\\\\\\\\\\\\/1JA2\\\\\\\\\\\\\\\/WEZeldq4\\\\\\\\\\\\\\\/5CE3CP\\\\\\\\\\\\\\\/8y3L0D6Ynr\\\\\\\\\\\\\\\/kWNiSG1YReriLefSqC1c8h0km3wk+mP8MzOEkrGIgeJMq5MD1xIsRNJ0E3b7umFmCpDCAdc1VqkKxKTOLJdil9FRpB99sXOSqcwOSxrarBFyupqG9xzdQNhzlgNX4BKOUBu5rb33PJZkfsZVDZNPU\\\\\\\\\\\\\\\/faHiBNeAf1IY+1Q2XePPYGS2\\\\\\\\\\\\\\\/GkMssqS1QTqJ7nWkPkOe5iMiHQllT8rVOmGomku0sq2Jirvhqwm+qCaHjuO2uh0QhJZcaFEb2Z2qGKQ67hwJ+wFCcXrCU3g54ns3tERmtxnr02qzwo28AP3Bj3mfzfhPDqJrkvk2g8ezYHIKEF1l0KkYga7frgjN7EahsiMpGo7xrA+ReVlaWkzdK6sNpHIs4YfAnEFeAc8XoykIyDhkdlrhhSxvFfPbIqVr3MFraKuud7EPNocrwp7cuTGc\\\\\\\\\\\\\\\/iF4bVPfT7Hx65tJU2Zp58v8caZAlrf+gQb7F+aI7bil57wIBz0mVxh468+mub49mm2dju3gLZvoQegITIzvMskxcZpORDYzIZ5mKfLZ1Bg9\\\\\\\\\\\\\\\/XYT5ouxfkwESQqZy6LlRe2cYWwIWdLLtDYy+r45s5r1kMIgPWm3T16GY8\\\\\\\\\\\\\\\/O5nxZIQJ01yylkAIDhfqRwKDdpKIkUlp65C17AM8qLgS3KOwWzfLRBlGDOg5wFWDmGUc3o\\\\\\\\\\\\\\\/U8Iaza2Et\\\\\\\\\\\\\\\/sQthB0Lecb7gG0rFxC8j7iI661Z8u2Q=\\\\\\u0022,\\\\\\u0022iv\\\\\\u0022:\\\\\\u0022\\\\\\\\\\\\\\\/ZG5woQjkvJKEmu0DhShDA==\\\\\\u0022,\\\\\\u0022salt\\\\\\u0022:\\\\\\u00223fcf69c0544933648ca27e63b3137e55\\\\\\u0022}\\u0022,\\u0022hmac\\u0022:\\u00222dbec1e300b9ea8e99737569abc791caccf860cfe56b972cea329c9a533b5cf6\\u0022}\u0022},\u0022highwire\u0022:{\u0022ac\u0022:{\u0022\\\/jitc\\\/6\\\/1\\\/97.atom\u0022:{\u0022access\u0022:{\u0022full\u0022:true,\u0022abstract\u0022:true},\u0022pisa_id\u0022:\u0022\u0022,\u0022apath\u0022:\u0022\\\/jitc\\\/6\\\/1\\\/97.atom\u0022,\u0022jcode\u0022:\u0022jitc\u0022}}},\u0022MutationObserver\u0022:{\u0022js\u0022:\u0022\\\/sites\\\/all\\\/libraries\\\/mutationobserver\\\/MutationObserver.js\u0022},\u0022ajaxPageState\u0022:{\u0022js\u0022:{\u00220\u0022:1,\u0022https:\\\/\\\/d1bxh8uas1mnw7.cloudfront.net\\\/assets\\\/embed.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/highwire\\\/highwire\\\/plugins\\\/content_types\\\/js\\\/highwire_altmetrics.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/contrib\\\/panels_ajax_pane\\\/panels_ajax_pane.js\u0022:1}}});\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Clink type=\u0022text\/css\u0022 rel=\u0022stylesheet\u0022 href=\u0022\/\/www.highwirestage.com\/sites\/default\/files\/advagg_css\/css__dn-cpI1YtkU_iLHgA5WhlkxgYWyat_IxjF_B-WSYrpE__a9hIbt0eaZ7d5nhwnm2weG8R_2eXK4EvoOx9dOxouHE__3qvfz4I9k5oUIeimOjbmdyh6ZgM-xweyVc5gub1_nR4.css\u0022 media=\u0022all\u0022\u003E\u003Clink rel=\u0022stylesheet\u0022 type=\u0022text\/css\u0022 href=\u0022\/sites\/all\/modules\/contrib\/panels\/plugins\/layouts\/onecol\/onecol.css\u0022\u003E\u003C\/head\u003E\u003Cbody\u003E\u003Cdiv class=\u0022panels-ajax-tab-panel panels-ajax-tab-panel-jnl-template-bmjj-tab-art\u0022\u003E\u003Cdiv class=\u0022panel-display panel-1col clearfix\u0022\u003E\n  \u003Cdiv class=\u0022panel-panel panel-col\u0022\u003E\n    \u003Cdiv\u003E\u003Cdiv class=\u0022panel-pane pane-dfp-pane oas-ads oas-ads-mid pull-right\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv id=\u0022dfp-ad-mpu-wrapper\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n\n\u003Cdiv id=\u0022dfp-ad-mpu\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n  \u003Cscript type=\u0022text\/javascript\u0022\u003E\n    googletag.cmd.push(function() {\n      googletag.display(\u0022dfp-ad-mpu\u0022);\n    });\n  \u003C\/script\u003E\u003C\/div\u003E\n\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-1\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003E\u003Ca href=\u0022https:\/\/doi.org\/10.1186\/s40425-018-0415-x\u0022 target=\u0022_new\u0022\u003Ehttps:\/\/doi.org\/10.1186\/s40425-018-0415-x\u003C\/a\u003E\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-altmetrics\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003EStatistics from Altmetric.com\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv data-badge-details=\u0022right\u0022 data-badge-type=\u0022medium-donut\u0022 data-doi=\u002210.1186\/s40425-018-0415-x\u0022 data-hide-no-mentions=\u0022true\u0022 class=\u0022altmetric-embed\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-2 permissions-box\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ERequest Permissions\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003EIf you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center\u0026rsquo;s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-panels-ajax-pane-content permissions-box pane-highwire-permission-link\u0022 id=\u0022request-permissions\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003E\u003Cspan class=\u0022panels-ajax-pane-title\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/span\u003E\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022panels-ajax-pane panels-ajax-pane-new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n  \u003C\/div\u003E\n\u003C\/div\u003E\n\u003C\/div\u003E\u003C\/body\u003E\u003C\/html\u003E\n"}