{"markup":"\u003C!DOCTYPE html PUBLIC \u0022-\/\/W3C\/\/DTD HTML 4.0 Transitional\/\/EN\u0022 \u0022http:\/\/www.w3.org\/TR\/REC-html40\/loose.dtd\u0022\u003E\n\u003C?xml version=\u00221.0\u0022 encoding=\u0022UTF-8\u0022 ?\u003E\u003Chtml version=\u0022HTML+RDFa+MathML 1.1\u0022 content=\u0022http:\/\/purl.org\/rss\/1.0\/modules\/content\/\u0022 dc=\u0022http:\/\/purl.org\/dc\/terms\/\u0022 foaf=\u0022http:\/\/xmlns.com\/foaf\/0.1\/\u0022 og=\u0022http:\/\/ogp.me\/ns#\u0022 rdfs=\u0022http:\/\/www.w3.org\/2000\/01\/rdf-schema#\u0022 sioc=\u0022http:\/\/rdfs.org\/sioc\/ns#\u0022 sioct=\u0022http:\/\/rdfs.org\/sioc\/types#\u0022 skos=\u0022http:\/\/www.w3.org\/2004\/02\/skos\/core#\u0022 xsd=\u0022http:\/\/www.w3.org\/2001\/XMLSchema#\u0022 mml=\u0022http:\/\/www.w3.org\/1998\/Math\/MathML\u0022\u003E\u003Chead\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\ngoogletag.slots[\u0022mpu\u0022] = googletag.defineSlot(\u0022\/21798771943\/JITC-MPU\u0022, [[300, 250], [300, 600], [300, 300], [600, 500]], \u0022dfp-ad-mpu\u0022)\n  .addService(googletag.pubads());\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022https:\/\/d1bxh8uas1mnw7.cloudfront.net\/assets\/embed.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/www.highwirestage.com\/sites\/default\/files\/js\/js_U2pncm4Q4A7IJl4J_deoOoy8h9tU-3gxfOF4iwZdk_g.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\njQuery.extend(Drupal.settings, {\u0022basePath\u0022:\u0022\\\/\u0022,\u0022pathPrefix\u0022:\u0022\u0022,\u0022panels_ajax_pane\u0022:{\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022:\u0022{\\u0022encrypted\\u0022:\\u0022{\\\\\\u0022encrypted\\\\\\u0022:\\\\\\u0022N58hrs948UfyiseOuaCMASeDb+zHwNuHIsX3TiMkIDG9ORv+gPcOXrMvH4R6U9+E5LUT6LRMtmYT2XIqIvFG8sn5kZHGw\\\\\\\\\\\\\\\/xg4Eew7z0c3A5MJw5oA4Xc1+R6I\\\\\\\\\\\\\\\/r\\\\\\\\\\\\\\\/Yewjgd11cpscTFpyoU82okbtkCcTAF9NQFhROfV2hHT9+sEArA9VvDH4BbwzRfjObFlssVBSZGRV8cvp6DrK49ao9+QdchlO5ME+k5cRADDXOeNABVWBb\\\\\\\\\\\\\\\/9tBmXOoAEFQJ63D89rbf2lmJuwgwl1uYapOX0NaQNhmnV\\\\\\\\\\\\\\\/CbR2vsZDTvqMvhLO997jQzsyt+z5VaphtIrVWYRjfKc4oxJlnbhGdxMRPuScvG6LNSvkIeRlb4WRsedIx7qanxW+6DYPqhJFXoD0ZisCB+2yecgPp46cHfeRZHCoha0yj8Fh9ENj1Osu4YeNAH93TXL1DBIbbC4Q31hm5eGp9wDIUwQ\\\\\\\\\\\\\\\/KdDidUGMRLNqITDbczp0MnxYIGkJrvTEVrFYBKO5zTLcISMpB3yY2cFps6xFPJL\\\\\\\\\\\\\\\/RqPqyGYBIEFKPF+Xk2Bs0nmIX9fC080Qvv73Rg30LzqpmstqkgBHlRHYnbYBTFqWAlq7l5+wABXmyBRWNygKjd31j6qqEjdurHaSk5+dkOcnCg6VWMl4GPy53bCnWkQlX7J+QqHR0oqryQKLPu7eDzUUvotrwsRfTD7Ua6Df6WZ8xINlV44gjnQdMoMFQuwoOAj0JLj52+L0A77sP7H+7jFx0l1\\\\\\\\\\\\\\\/QlTphMakTBTC6R9dFjgAz09Ax4zLz0qPstI2Zsi1ABUKNZ1OJnDHXvM\\\\\\\\\\\\\\\/J4Qzct\\\\\\\\\\\\\\\/SEsmGVri8BPiBV4vaNrkDytFmnRtrGtHdkHAEXDXP8Y+mcFycRjS+INsltSlDHJtkmgd1wZe0GR6XNzLWqmankAuxvSwGTqp6gKPZ85RIcPEiHcrcv0QDBE1n3TCWXuLBT11wO0L6bfX3VP0n7kAtXxnldTjv\\\\\\\\\\\\\\\/8FjwXpMRIVJo1gTYcKSDjeRwrN5ny\\\\\\\\\\\\\\\/0wKdDvWdj\\\\\\\\\\\\\\\/FRLwUhu2\\\\\\\\\\\\\\\/aSp1pFb+hlPg1UzEk8umFGMYgw2cNQhLpAcRdSH7ZdLaAppnfEEQHL6wQs5ZSVm2OEu\\\\\\\\\\\\\\\/wz\\\\\\\\\\\\\\\/D3QJ5xZyr0jxmBTz5OcjhjGAoVDEC1LbmCSvVGhkfiJHHcsQrEwqCdZZI8Tmog5maobDcPN33Wtf2F0p1MHTjFLUYl9wi2kqPzST5o8TwB5zmlQxgdfd0J8AiHo3SHDr\\\\\\\\\\\\\\\/vDa6bBTWAJg0BV8JO49D4SZa6oY\\\\\\\\\\\\\\\/nRyo\\\\\\\\\\\\\\\/oZKhNpqaEr\\\\\\\\\\\\\\\/jMYTge3NsinNaC6h9E0QpdqCFgV30tJs8jUJAVDG\\\\\\\\\\\\\\\/WOZbeTCJDtrVTGFY2WIqgpYMG0B51rzdIeUa\\\\\\\\\\\\\\\/O6p5kLo5xOP1DwCuoZ0nP19+HTvr6fHP+kcQFiLhy5Ha+9TvuOCcphX+eb8nBwtQEWTfZ886MwC8dby1lfczPE\\\\\\\\\\\\\\\/g4edt5KtoXa6ZdkNn24AlzKQVVM44yvZkP2znVQWY7A57GbjOxsCfyTVkO6tD819Kdwae0AEMSO82rsjIr7lte1awxds5sJNxvzhp35OAZyJEmzSfrTDKg+tQ8zA9bZUUITsr+ZPXdXQ4ZpYopuemcrt8BCoFN+md\\\\\\\\\\\\\\\/V0ZJwv05KfCO2XEKuJGo8uDKeNetaQGTDLA4T1uCVX7fnI6WQcYveGZl8X0ZGQu8fLBILTITsaAZma+v7w8FUVAzYR3UHrubTeokLnaw10w5dWbqKmuf8A6nEtAJAASlNie0s3YRLqi7g\\\\\\\\\\\\\\\/MdlHjNlqPcLfm6mBJJuEh6NKQFXVrmzst8X9Qx+hKC6RBRwOfSDn7rWMIJEcb4\\\\\\\\\\\\\\\/\\\\\\\\\\\\\\\/UM1P1B5CZhZSJ9u587WblbshYXrXOYLniEUv+Iq\\\\\\\\\\\\\\\/EaCQsaVR0Hev+cSMOSAh3\\\\\\\\\\\\\\\/r7C0zC0oKqIbf1ljeKE3eav6Lro5CrLUXlxyAB8xT8XmQU6vzU0Upct\\\\\\\\\\\\\\\/5HhXrdi1v+8Qbip67hi9G2hwe4pqyTHfuCpJJIl+LU\\\\\\\\\\\\\\\/+UGCS2Z46e90jE5SBOi\\\\\\\\\\\\\\\/qrsVSHi1njKf94tOdWCHTMBPYQo6XaDHSwkplXLMfLAcJ0g5RJxfPBonj8glE3zVFYCpxZq\\\\\\\\\\\\\\\/Jn1vsJCBIFaUu1PYqPooVrX8KHxWCHc+E9x0FfptKP998rRXLXmDAF1k073feJ9Z7aL4gex1YdObZz9eWua87shd0618J1sK0zR8gQK4MZuN8DE5nzn0GrHKh0vDnuU6Q\\\\\\\\\\\\\\\/vnnn2mOpdYzuKjl\\\\\\\\\\\\\\\/ylMoz3dxT072rLMb0TLfIx8R0o0AJsATJ3jcm6LcZzqXtwev8FMF\\\\\\\\\\\\\\\/APZ+xV872WEZDEp4gVrtzTyhQy\\\\\\\\\\\\\\\/XepQBEw3VhYIs094\\\\\\\\\\\\\\\/SUKdW0FYdgN4leM6O79ZhUT450HaAX1D\\\\\\\\\\\\\\\/1QgolD02SBQtYZArr30ydMNP5ym+D90BVkYLzoxzvwoZvCkOMRYmiZMS2c8g3r5ffJPf1L76R1tDeMLSwHXmqUFsdKh6vhIKw7T69PHK0CXfBJ2M9bZ3UUMTOaa\\\\\\\\\\\\\\\/o6CW2aAaafmCEDRmAI3XcOKg9K9qd1Ss\\\\\\\\\\\\\\\/yGPfA6FGrhJN0Ff49tPn7zcdymqvsHFcDT7nbFDn0ifmDZ2ujekoT28Xi9LCWonoWTkbS2Tf1gf+sU+1r0dDOv7j4vJblgK6+bzBR+JDhbilyTxqc\\\\\\\\\\\\\\\/qOxv8P3Y=\\\\\\u0022,\\\\\\u0022iv\\\\\\u0022:\\\\\\u0022h0nC3+fIX1CmXv8uI6vByA==\\\\\\u0022,\\\\\\u0022salt\\\\\\u0022:\\\\\\u00223fcf69c0544933648ca27e63b3137e55\\\\\\u0022}\\u0022,\\u0022hmac\\u0022:\\u0022681b23a04d2374c923fe9e2be180412ed58658dff68646a815aecd2c4c756016\\u0022}\u0022},\u0022highwire\u0022:{\u0022ac\u0022:{\u0022\\\/jitc\\\/6\\\/1\\\/159.atom\u0022:{\u0022access\u0022:{\u0022full\u0022:true,\u0022abstract\u0022:true},\u0022pisa_id\u0022:\u0022\u0022,\u0022apath\u0022:\u0022\\\/jitc\\\/6\\\/1\\\/159.atom\u0022,\u0022jcode\u0022:\u0022jitc\u0022}}},\u0022MutationObserver\u0022:{\u0022js\u0022:\u0022\\\/sites\\\/all\\\/libraries\\\/mutationobserver\\\/MutationObserver.js\u0022},\u0022ajaxPageState\u0022:{\u0022js\u0022:{\u00220\u0022:1,\u0022https:\\\/\\\/d1bxh8uas1mnw7.cloudfront.net\\\/assets\\\/embed.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/highwire\\\/highwire\\\/plugins\\\/content_types\\\/js\\\/highwire_altmetrics.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/contrib\\\/panels_ajax_pane\\\/panels_ajax_pane.js\u0022:1}}});\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Clink type=\u0022text\/css\u0022 rel=\u0022stylesheet\u0022 href=\u0022\/\/www.highwirestage.com\/sites\/default\/files\/advagg_css\/css__dn-cpI1YtkU_iLHgA5WhlkxgYWyat_IxjF_B-WSYrpE__a9hIbt0eaZ7d5nhwnm2weG8R_2eXK4EvoOx9dOxouHE__3qvfz4I9k5oUIeimOjbmdyh6ZgM-xweyVc5gub1_nR4.css\u0022 media=\u0022all\u0022\u003E\u003Clink rel=\u0022stylesheet\u0022 type=\u0022text\/css\u0022 href=\u0022\/sites\/all\/modules\/contrib\/panels\/plugins\/layouts\/onecol\/onecol.css\u0022\u003E\u003C\/head\u003E\u003Cbody\u003E\u003Cdiv class=\u0022panels-ajax-tab-panel panels-ajax-tab-panel-jnl-template-bmjj-tab-art\u0022\u003E\u003Cdiv class=\u0022panel-display panel-1col clearfix\u0022\u003E\n  \u003Cdiv class=\u0022panel-panel panel-col\u0022\u003E\n    \u003Cdiv\u003E\u003Cdiv class=\u0022panel-pane pane-dfp-pane oas-ads oas-ads-mid pull-right\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv id=\u0022dfp-ad-mpu-wrapper\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n\n\u003Cdiv id=\u0022dfp-ad-mpu\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n  \u003Cscript type=\u0022text\/javascript\u0022\u003E\n    googletag.cmd.push(function() {\n      googletag.display(\u0022dfp-ad-mpu\u0022);\n    });\n  \u003C\/script\u003E\u003C\/div\u003E\n\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-1\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003E\u003Ca href=\u0022https:\/\/doi.org\/10.1186\/s40425-018-0482-z\u0022 target=\u0022_new\u0022\u003Ehttps:\/\/doi.org\/10.1186\/s40425-018-0482-z\u003C\/a\u003E\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-altmetrics\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003EStatistics from Altmetric.com\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv data-badge-details=\u0022right\u0022 data-badge-type=\u0022medium-donut\u0022 data-doi=\u002210.1186\/s40425-018-0482-z\u0022 data-hide-no-mentions=\u0022true\u0022 class=\u0022altmetric-embed\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-2 permissions-box\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ERequest Permissions\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003EIf you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center\u0026rsquo;s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-panels-ajax-pane-content permissions-box pane-highwire-permission-link\u0022 id=\u0022request-permissions\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003E\u003Cspan class=\u0022panels-ajax-pane-title\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/span\u003E\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022panels-ajax-pane panels-ajax-pane-new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n  \u003C\/div\u003E\n\u003C\/div\u003E\n\u003C\/div\u003E\u003C\/body\u003E\u003C\/html\u003E\n"}