{"markup":"\u003C!DOCTYPE html PUBLIC \u0022-\/\/W3C\/\/DTD HTML 4.0 Transitional\/\/EN\u0022 \u0022http:\/\/www.w3.org\/TR\/REC-html40\/loose.dtd\u0022\u003E\n\u003C?xml version=\u00221.0\u0022 encoding=\u0022UTF-8\u0022 ?\u003E\u003Chtml version=\u0022HTML+RDFa+MathML 1.1\u0022 content=\u0022http:\/\/purl.org\/rss\/1.0\/modules\/content\/\u0022 dc=\u0022http:\/\/purl.org\/dc\/terms\/\u0022 foaf=\u0022http:\/\/xmlns.com\/foaf\/0.1\/\u0022 og=\u0022http:\/\/ogp.me\/ns#\u0022 rdfs=\u0022http:\/\/www.w3.org\/2000\/01\/rdf-schema#\u0022 sioc=\u0022http:\/\/rdfs.org\/sioc\/ns#\u0022 sioct=\u0022http:\/\/rdfs.org\/sioc\/types#\u0022 skos=\u0022http:\/\/www.w3.org\/2004\/02\/skos\/core#\u0022 xsd=\u0022http:\/\/www.w3.org\/2001\/XMLSchema#\u0022 mml=\u0022http:\/\/www.w3.org\/1998\/Math\/MathML\u0022\u003E\u003Chead\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\ngoogletag.slots[\u0022mpu\u0022] = googletag.defineSlot(\u0022\/21798771943\/JITC-MPU\u0022, [[300, 250], [300, 600], [300, 300], [600, 500]], \u0022dfp-ad-mpu\u0022)\n  .addService(googletag.pubads());\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022https:\/\/d1bxh8uas1mnw7.cloudfront.net\/assets\/embed.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/www.highwirestage.com\/sites\/default\/files\/js\/js_U2pncm4Q4A7IJl4J_deoOoy8h9tU-3gxfOF4iwZdk_g.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\njQuery.extend(Drupal.settings, {\u0022basePath\u0022:\u0022\\\/\u0022,\u0022pathPrefix\u0022:\u0022\u0022,\u0022panels_ajax_pane\u0022:{\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022:\u0022{\\u0022encrypted\\u0022:\\u0022{\\\\\\u0022encrypted\\\\\\u0022:\\\\\\u0022aaz1\\\\\\\\\\\\\\\/UGO7\\\\\\\\\\\\\\\/6GaFhgVmwUIfEo\\\\\\\\\\\\\\\/DTl8FmzcVWe1pMFdum7ooDqurV4eD+gKlXJy2XFvAkn8S4xvg9oWHvw3oTrNGaxgxyjfLDpb4nKRYtCE2njjvrbeJfm707S+ft4Nqkm\\\\\\\\\\\\\\\/iIEwGNFBfvKuxIWio3jauj0QmWQfzg1Z7JnWF1SJa8NHBTJo2QthdVdfsyXnd5OJ9zzd3bEiBjiJUaKdrOrHqpQ51AGuTx2pdDPrSKPTl74kqxEl7zfVqaRUog1q79LU+kCjCKSuvgLdOk3MAzmEL2oLsiwv\\\\\\\\\\\\\\\/TmtQiaqOPYJdXpks\\\\\\\\\\\\\\\/xKaU1ZjPMEliXWVJMMRcDVkctNRC51kSASBqb9OM3LksQazXBTvtT4AeY29U+hE1jeoYQXw1DwxRrTlqEGECiLek9mvdERDiXxB7eKqxoByjb7ejZFAsiW1jAorSKfs6yuLBmDUXACDggqEv8ftyzyX3ZuPb0jPnJmVZbwujQRlNqIj9PouftO18vWnP2chTpJfuXCoKmgWb1RU1VqQ6KYHCjwyW2Lt4LXKaOuOHgDjfAOzq2gA4tiKLTdicmKBPqFkDvC3B\\\\\\\\\\\\\\\/MqqbX3Sp8Hfh137B2RmZTdupv4MXSuIK1LqT4ipycR9IPSfJTuqpzr0y4UPo3axbSC9SSJr6con0lp6BBSRctt6OfJ0P7NMHEb6v32L+w8I1lya8p1h1i2hCAkZLJrXF2sbcxv7pf8GLS45VolbRgBcjaP2VDy0cuFL1dbOnaZUZnZPqlTJ5i2ww1WI0Q03ajif31xHGLwzfH44zsPUyKMKpHrdaCaHV2ztZhUULfOwN+3wgKAba3DUGFoCUFfCUS2XKlXFA1jQkLWThybNkEZ8qJ6dyctodyuhhWhThbfNjz47nYbSQNs5KUXmfK+0ameGx8eMAGRiae\\\\\\\\\\\\\\\/em3Fw0F686PVYiwNQUGimTd++O7O4O536hGz5VBA89KyQ4L+wzSH1npsoV7GZkVlwXjF4w8No6jR0\\\\\\\\\\\\\\\/x6r59etNP5G6Fr3Kg7xKyM8DNiR0wm0JtygcE0oiHgIiGaSd6+IDJ2QAUGpPAb5K\\\\\\\\\\\\\\\/MV+vHVjP9fuuGwT4W200zGDD+wzfp7KJy49kx+nrgvxP+E6laaq5hbDTr+rf0p2myzqnddHxwUc\\\\\\\\\\\\\\\/\\\\\\\\\\\\\\\/0LfR\\\\\\\\\\\\\\\/29HcB+smTiwVRhLVGBiEv\\\\\\\\\\\\\\\/Pm4lJsJSyiw90XaVYni\\\\\\\\\\\\\\\/ZOBxHOafnVtD0u\\\\\\\\\\\\\\\/TY3mycZDGKWd5IPGHH\\\\\\\\\\\\\\\/rgt0nEHLKldsr5n42pGx0cTBVJBwrKbbhWPljcVg0pxx+g2+CVYpSDSmWdQZMY+dweToFl9n5RsmXrg5IYsh1or\\\\\\\\\\\\\\\/G8UnmFHQ73aibUCV\\\\\\\\\\\\\\\/mbEKcWIBoGGHSJaEoF6DryXH0tS6Sqmhr+PXGB+w9AlpK4Q2bWTgIAikRCeAx10WFRzgobV\\\\\\\\\\\\\\\/JcgEWgyv8KCPjjZ+8aeQq8hdOeT6yZ4s5GnkIcVI8mpDLBErfcshYyQcHnWP9EBCVjuIsLT4fOVgxhzxUi2\\\\\\\\\\\\\\\/UgC\\\\\\\\\\\\\\\/ELo7VkPChGopfUAGtkU5kE0+26mrfTWOX3IDlyhUMTkqPzwPIel9bInjq4Tuiz+ZS2fmgDL2a8CfO+sT9yBJTrprZ25LhzbAE+HIXSkoqUjvkifdymLx1IHJJelUo6G+MrHEFjqJPfl9xt9eFS8WKv5xUFszz6+r7LUoN6YfAOkg\\\\\\\\\\\\\\\/HHGaEjQIRlF3c1KWBHKTe3WhZxhrxuNu3saNacdjllpLZhAJH9GuuSX6gVt3yLSmp9hJQ1OBaYfy1jMTj6Ne\\\\\\\\\\\\\\\/AX\\\\\\\\\\\\\\\/35CAEY07ex+v6qC5Xbgzkc\\\\\\\\\\\\\\\/czoIlpjE3GkhNtPq5Fd8cLx6cgsJuIDSzSuP8NzBsw96M5N9Xso5bjaja5p3SA9En+T+iUedDGzoMVFbrg3Fwq7r531tnpGes9kv4ySC89u\\\\\\\\\\\\\\\/AXX6ztARt7X3Ppp26MH2\\\\\\\\\\\\\\\/ebGgGY9lM37kq+HgoJXrAMLt8AnLqLZJUo1Iz00UpuulIYFP72nohTaXJ+8woDHzdzCZ0edh\\\\\\\\\\\\\\\/ah20bKQ9DQIQLRqBPfU62hzRTmGn+MAD0EYCFTDxPYVA0Xd0M+zYSqGzM\\\\\\\\\\\\\\\/Z9Wu11mfRzIXzSlFUGu5xGRfXtHuRlWCVa3t8AJQAFMkPjq\\\\\\\\\\\\\\\/7VD6uJvrgMxPF4O3G01fb1Z4AGgX4UkSTymB70hBv6oHb4nhoJHcIjb4gSJ+OjwahxRSa5XBWGnHQtGJrzglCBENDXR9w0bhxa6zkJYFDkIYicbSPQ0tmVgLFK3GaBHJjWF7G0D3JVLXzNEJiGfNwtvlyibW7ld4lB8SSpx99+c70pkP3yoM\\\\\\\\\\\\\\\/4dQLRp2yRmNmNz59GU9ZYuiXUC2g65gR\\\\\\\\\\\\\\\/9FJEG6hsySVc6soOACordzGX26fBOX\\\\\\\\\\\\\\\/tYtEekLfBFpqDZzTD6J2CELgroZ5WsE0JYUmHFqa\\\\\\\\\\\\\\\/lYWABtp8uhdC4ucGPfX5mAry4OZqMKPDUEibo9QheMYQwI6QzIfnt7mli29mqntsJ+XwXFJrXxXrlH119Cx3egSALxTUHcY27AoOIDf+kBBBLgIly+c\\\\\\\\\\\\\\\/vddpDZ9MX5CZTpqiYl45RdCJ5sj5J403yDCoabL8yMMKu+rTfvurMkZw9uI170r7S65Fd9dmaTggiYA8MBzA7MknBktL0NEl9kZ7\\\\\\\\\\\\\\\/kEmNMTl4ercLJXkEeVk6OCOjoyvc23ENK6TIN3XM=\\\\\\u0022,\\\\\\u0022iv\\\\\\u0022:\\\\\\u0022TYcdK5itcszKlx1cbjI+vA==\\\\\\u0022,\\\\\\u0022salt\\\\\\u0022:\\\\\\u00223fcf69c0544933648ca27e63b3137e55\\\\\\u0022}\\u0022,\\u0022hmac\\u0022:\\u00222b03607e8d9c5c009980ccdd256749b286c9bab10172f4ac5e3d300e57975d05\\u0022}\u0022},\u0022highwire\u0022:{\u0022ac\u0022:{\u0022\\\/jitc\\\/6\\\/1\\\/159.atom\u0022:{\u0022access\u0022:{\u0022full\u0022:true,\u0022abstract\u0022:true},\u0022pisa_id\u0022:\u0022\u0022,\u0022apath\u0022:\u0022\\\/jitc\\\/6\\\/1\\\/159.atom\u0022,\u0022jcode\u0022:\u0022jitc\u0022}}},\u0022MutationObserver\u0022:{\u0022js\u0022:\u0022\\\/sites\\\/all\\\/libraries\\\/mutationobserver\\\/MutationObserver.js\u0022},\u0022ajaxPageState\u0022:{\u0022js\u0022:{\u00220\u0022:1,\u0022https:\\\/\\\/d1bxh8uas1mnw7.cloudfront.net\\\/assets\\\/embed.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/highwire\\\/highwire\\\/plugins\\\/content_types\\\/js\\\/highwire_altmetrics.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/contrib\\\/panels_ajax_pane\\\/panels_ajax_pane.js\u0022:1}}});\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Clink type=\u0022text\/css\u0022 rel=\u0022stylesheet\u0022 href=\u0022\/\/www.highwirestage.com\/sites\/default\/files\/advagg_css\/css__dn-cpI1YtkU_iLHgA5WhlkxgYWyat_IxjF_B-WSYrpE__a9hIbt0eaZ7d5nhwnm2weG8R_2eXK4EvoOx9dOxouHE__3qvfz4I9k5oUIeimOjbmdyh6ZgM-xweyVc5gub1_nR4.css\u0022 media=\u0022all\u0022\u003E\u003Clink rel=\u0022stylesheet\u0022 type=\u0022text\/css\u0022 href=\u0022\/sites\/all\/modules\/contrib\/panels\/plugins\/layouts\/onecol\/onecol.css\u0022\u003E\u003C\/head\u003E\u003Cbody\u003E\u003Cdiv class=\u0022panels-ajax-tab-panel panels-ajax-tab-panel-jnl-template-bmjj-tab-art\u0022\u003E\u003Cdiv class=\u0022panel-display panel-1col clearfix\u0022\u003E\n  \u003Cdiv class=\u0022panel-panel panel-col\u0022\u003E\n    \u003Cdiv\u003E\u003Cdiv class=\u0022panel-pane pane-dfp-pane oas-ads oas-ads-mid pull-right\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv id=\u0022dfp-ad-mpu-wrapper\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n\n\u003Cdiv id=\u0022dfp-ad-mpu\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n  \u003Cscript type=\u0022text\/javascript\u0022\u003E\n    googletag.cmd.push(function() {\n      googletag.display(\u0022dfp-ad-mpu\u0022);\n    });\n  \u003C\/script\u003E\u003C\/div\u003E\n\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-1\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003E\u003Ca href=\u0022https:\/\/doi.org\/10.1186\/s40425-018-0482-z\u0022 target=\u0022_new\u0022\u003Ehttps:\/\/doi.org\/10.1186\/s40425-018-0482-z\u003C\/a\u003E\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-altmetrics\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003EStatistics from Altmetric.com\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv data-badge-details=\u0022right\u0022 data-badge-type=\u0022medium-donut\u0022 data-doi=\u002210.1186\/s40425-018-0482-z\u0022 data-hide-no-mentions=\u0022true\u0022 class=\u0022altmetric-embed\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-2 permissions-box\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ERequest Permissions\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003EIf you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center\u0026rsquo;s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-panels-ajax-pane-content permissions-box pane-highwire-permission-link\u0022 id=\u0022request-permissions\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003E\u003Cspan class=\u0022panels-ajax-pane-title\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/span\u003E\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022panels-ajax-pane panels-ajax-pane-new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n  \u003C\/div\u003E\n\u003C\/div\u003E\n\u003C\/div\u003E\u003C\/body\u003E\u003C\/html\u003E\n"}